Christine B. Sethna
A5046125309- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Birth, Development, and Health
- Central Venous Catheters and Hemodialysis
- Childhood Cancer Survivors' Quality of Life
- Acute Kidney Injury Research
- Blood Pressure and Hypertension Studies
- Adolescent and Pediatric Healthcare
- Complement system in diseases
- Electrolyte and hormonal disorders
- Ion Transport and Channel Regulation
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Hemodynamic Monitoring and Therapy
- Renal Transplantation Outcomes and Treatments
- Hormonal Regulation and Hypertension
- Cardiac, Anesthesia and Surgical Outcomes
- Vagus Nerve Stimulation Research
- Vasculitis and related conditions
- Renal and related cancers
- Chronic Lymphocytic Leukemia Research
- Porphyrin Metabolism and Disorders
- Escherichia coli research studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Bipolar Disorder and Treatment
Cohen Children's Medical Center
2015-2024
Northwell Health
2014-2024
Feinstein Institute for Medical Research
2021-2023
Hofstra University
2018-2023
North Shore Diabetes and Endocrine Associates
2023
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2021-2022
Christ University
2022
Schneider Children's Hospital
2021
Arbor Research Collaborative for Health
2017
Children's Hospital of Philadelphia
2009-2017
The application of deep learning for automated segmentation (delineation boundaries) histologic primitives (structures) from whole slide images can facilitate the establishment novel protocols kidney biopsy assessment. Here, we developed and validated networks structures on biopsies nephrectomies. For development, examined 125 Minimal Change Disease collected across 29 NEPTUNE enrolling centers along with 459 stained Hematoxylin & Eosin (125), Periodic Acid Schiff Silver (102), Trichrome...
This study describes the incidence, associated clinical characteristics and outcomes of acute kidney injury in a pediatric cohort with COVID-19 Multisystem Inflammatory Syndrome Children (MIS-C). We performed retrospective patients 18 years age under admitted to four New York hospitals Northwell Health System interned during height pandemic, between March 9 August 13, 2020. Acute was defined staged according Kidney Disease: Improving Global Outcomes criteria. The included 152 patients; 97...
Background and objectives The Standardizing Care to Improve Outcomes in Pediatric ESRD Collaborative is a quality improvement initiative that aims reduce peritoneal dialysis–associated infections pediatric patients on chronic dialysis. Our were determine whether provider compliance with dialysis catheter care bundles was associated lower risk for infection at the individual patient level describe epidemiology, factors, outcomes peritonitis Collaborative. Design, setting, participants, &...
This analysis from the Nephrotic Syndrome Study Network (NEPTUNE) assessed phenotypic and pathology characteristics of proteinuric patients undergoing kidney biopsy defined frequency factors associated with complete proteinuria remission (CRever).We enrolled adults children ≥0.5 g/d at time first clinically indicated renal 21 sites in North America April 2010 to June 2014 into a prospective cohort study. NEPTUNE central pathologists assigned participants minimal-change disease (MCD), FSGS,...
Individuals of African ancestry harboring two variant alleles within apolipoprotein L1 ( APOL1 ) are classified with a high-risk (HR) genotype. Adults an HR genotype have increased risk focal segmental glomerulosclerosis and chronic kidney disease compared those low-risk (LR) (0 or 1 variants). The role genotypes in children glomerular is less well known.This study characterized 104 African-American by cohorts: the Chronic Kidney Disease Children (CKiD) Nephrotic Syndrome Study Network...
Cardiovascular disease is prevalent among childhood cancer survivors (CCS). Arterial stiffness measured by pulse wave velocity (PWV) may be predictive of cardiovascular morbidity. Increased PWV has been seen in adults following chemotherapy.To evaluate a cohort CCS and healthy controls.All participants were >6 years old. >12 months off-therapy free cardiac disease, diabetes, kidney dysfunction. Height, weight, blood pressure (BP), medications, diagnosis, age at time off therapy,...
Purpose: Acute kidney injury (AKI) is an independent predictor of morbidity and mortality in critically ill infants children. AKI develops estimated one-third the neonatal intensive care unit (NICU) population; however, literature on incidence premature with a diagnosis necrotizing enterocolitis (NEC) limited. The objectives this study were to describe radiographically confirmed NEC, assess these for risk factors associated development evaluate if presence increased mortality.Study design:...
Background Cardiovascular disease is a major cause of morbidity and mortality in children with chronic kidney disease. We sought to determine the prevalence cardiovascular risk factors glomerular describe current practice patterns regarding factor identification management. Methods Results Seven-hundred sixty-one aged 0 17 years any 4 biopsy-confirmed primary diseases (minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, IgA nephropathy/vasculitis) were...
Focal segmental glomerulosclerosis (FSGS) is a common cause of end-stage kidney disease (ESKD) across the lifespan. While 10% to 15% children and 3% adults who develop ESKD have FSGS, it remains uncertain whether natural history differs in pediatric vs adult patients, this uncertainty contributes exclusion adolescents clinical trials.
APOL1 risk variants are associated with increased of kidney disease in patients African ancestry, but not all individuals the high-risk genotype develop disease. As gene expression correlates closely degree cell injury both and animal models, mechanisms regulating may be critical determinants allele penetrance. The messenger RNA includes Alu elements at 3′ untranslated region that can form a double-stranded structure (Alu-dsRNA) susceptible to posttranscriptional adenosine deaminase acting...
Most cases of idiopathic nephrotic syndrome in childhood are responsive to corticosteroids. However, there is a small group children that demonstrate steroid resistance (steroid-resistant syndrome; SRNS), dependence, or frequently relapse (frequent-relapse steroid-sensitive FR-SSNS) which more clinically difficult treat. Therefore, second-line immunosuppressants, such as alkylating agents, calcineurin inhibitors, antimetabolites and, recently, rituximab, have been used with varying success....
Acute kidney injury is an independent risk factor for morbidity and mortality in critically ill children the PICU. Neonates are a particularly vulnerable subgroup regarding acute injury. The objectives were to define prevalence of assess factors, development injury, determine impact on outcomes neonates without history cardiac surgery.A retrospective study (≤ 28 d old ≥ 32 wk gestational age) admitted tertiary PICU was conducted. classified using Kidney Disease: Improving Global Outcomes...
Growth impairment remains common in children with chronic kidney disease (CKD). Available literature indicates low level of recombinant human growth hormone (rhGH) utilization short CKD. Despite efforts at consensus guidelines, lack high-level evidence continues to complicate rhGH therapy decision-making and the practice variability treatment by pediatric nephrologists is unknown. Cross-sectional online survey electronically distributed through Midwest Pediatric Nephrology Consortium...
BACKGROUND AND OBJECTIVES: Congenital or primary nephrogenic diabetes insipidus (NDI) is a rare genetic disorder that severely impairs renal concentrating ability, resulting in massive polyuria. There limited information about prognosis evidence guiding the management of these patients, either high-risk period after diagnosis, long-term. We describe clinical presentation, etiology, treatment and outcomes large group children < 21 years with NDI. DESIGN: A multi-center retrospective chart...
Prior cross-sectional studies suggest that health-related quality of life (HRQOL) worsens with more severe glomerular disease. This longitudinal analysis was conducted to assess changes in HRQOL changing disease status.Cure Glomerulonephropathy (CureGN) is a cohort patients minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, IgA vasculitis, or nephropathy. assessed at enrollment and follow-up visits 1 3 times annually for up 5 years the Patient-Reported...