A5069979408- Renal and Vascular Pathologies
- Renal and related cancers
- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- RNA regulation and disease
- Tissue Engineering and Regenerative Medicine
- Gut microbiota and health
- Genetic and Kidney Cyst Diseases
- Oral Health Pathology and Treatment
- Immune Response and Inflammation
- CRISPR and Genetic Engineering
- Reproductive System and Pregnancy
- Neurological Complications and Syndromes
- Body Composition Measurement Techniques
- Organ Transplantation Techniques and Outcomes
- Oral microbiology and periodontitis research
- Cytomegalovirus and herpesvirus research
- Pluripotent Stem Cells Research
- 3D Printing in Biomedical Research
- Advanced Glycation End Products research
- Immune Cell Function and Interaction
- Pregnancy and Medication Impact
- Aortic aneurysm repair treatments
- Autopsy Techniques and Outcomes
- Transplantation: Methods and Outcomes
Massachusetts General Hospital
2022-2025
Harvard University
2023-2025
Universidade Federal do Paraná
2021-2023
Two variants in the gene encoding apolipoprotein L1 (APOL1) that are highly associated with African ancestry major contributors to large racial disparity rates of human kidney disease. We previously demonstrated recruitment APOL1 risk G1 and G2 from endoplasmic reticulum lipid droplets leads reduced APOL1-mediated cytotoxicity podocytes.We used CRISPR-Cas9 editing induced pluripotent stem cells develop human-derived APOL1G0/G0 APOL1G2/G2 organoids on an isogenic background, performed bulk...
APOL1 risk variants are associated with increased of kidney disease in patients African ancestry, but not all individuals the high-risk genotype develop disease. As gene expression correlates closely degree cell injury both and animal models, mechanisms regulating may be critical determinants allele penetrance. The messenger RNA includes Alu elements at 3′ untranslated region that can form a double-stranded structure (Alu-dsRNA) susceptible to posttranscriptional adenosine deaminase acting...
Background. There are no high-quality data to guide long-term mycophenolate mofetil (MMF) dosing in kidney transplant recipients (KTRs) balance the risks of allograft rejection with that infections and malignancy. At our center, KTRs managed either a “preemptive” dose reduction strategy, where MMF is reduced after first year before development adverse events, or “reactive” they maintained on same only if develop an event. We hypothesized preemptive strategy transplantation associated...
Yatim, Karim; Jurdi, Ayman Al; Ribas, Guilherme Taborda; Morena, Leela; Riella, Leonardo V. Author Information
Abstract Background A-to-I RNA editing, mediated by ADAR enzymes, plays a crucial role in cancer and autoimmune disorders but lacks standardized tools for differential analysis. After reviewing 55 studies, it highlights significant methodological heterogeneity, hindering result comparability reproducibility. To address this, we developed a2iHelper, Python package that streamlines editing analysis filtering noise, performing statistical analyses, generating visualizations. a2iHelper...
Abstract Early after transplantation, inflammation and tissue injury are associated with significant activation of the innate immune cells, such as DCs. This drives adaptive responses, triggering acute rejection while hindering development transplant tolerance. Current immunosuppressive drugs primarily target T immunity is not efficiently inhibited in transplantation. The sialic acid–binding immunoglobulin-like lectin E (Siglec-E, or SigE) an receptor that binds to ligands carrying acids...
Summary The increasing scarcity of organs and the significant morbidity linked to dialysis requires development engineered kidney tissues from human-induced pluripotent stem cells. To accomplish this, integrative approaches that synergize scalable organoid differentiation, tissue biomanufacturing, comprehensive assessment their immune response host integration are essential. Here, we create human composed building blocks (OBBs) transplant them into mice reconstituted with allogeneic We...
Introduction Cardiovascular disease is a significant cause of mortality after kidney transplantation. Whether pre-transplant screening for coronary artery (CAD) in asymptomatic transplant candidates (KTCs) beneficial unclear. Methods We conducted retrospective cohort study evaluating post-transplant cardiovascular events 192 high-risk KTCs who underwent CAD evaluation. The aimed to identify risk factors associated with finding severe on angiography, and assess the relationship between...