A5033700485- Antibiotic Use and Resistance
- Pneumonia and Respiratory Infections
- Antibiotics Pharmacokinetics and Efficacy
- Respiratory viral infections research
- Pharmaceutical studies and practices
- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Nosocomial Infections in ICU
- Emergency and Acute Care Studies
- Neonatal and Maternal Infections
- Central Venous Catheters and Hemodialysis
- Child and Adolescent Health
- Patient Satisfaction in Healthcare
- COVID-19 and Mental Health
- Bacterial Infections and Vaccines
- Influenza Virus Research Studies
- Respiratory and Cough-Related Research
- Pediatric health and respiratory diseases
- Infective Endocarditis Diagnosis and Management
- Vaccine Coverage and Hesitancy
- Antibiotic Resistance in Bacteria
- Cardiac, Anesthesia and Surgical Outcomes
- Sepsis Diagnosis and Treatment
- Surgical site infection prevention
Washington University in St. Louis
2016-2025
The Ohio State University
2024-2025
Nationwide Children's Hospital
2024-2025
St. Louis Children's Hospital
2016-2024
Office of Infectious Diseases
2023
Museum of Heilongjiang Province
2021
University of Missouri–Kansas City
2010-2020
Children's Hospital & Medical Center
2020
Children's Mercy Hospital
2010-2019
Mercy Hospital
2013-2019
Abstract Evidence-based guidelines for implementation and measurement of antibiotic stewardship interventions in inpatient populations including long-term care were prepared by a multidisciplinary expert panel the Infectious Diseases Society America Healthcare Epidemiology America. The included clinicians investigators representing internal medicine, emergency microbiology, critical care, surgery, epidemiology, pharmacy, adult pediatric infectious diseases specialties. These recommendations...
<h3>Importance</h3> The National Action Plan for Combating Antibiotic-Resistant Bacteria set a goal of reducing inappropriate outpatient antibiotic use by 50% 2020, but the extent is unknown. <h3>Objective</h3> To estimate rates oral prescribing age and diagnosis, estimated portions that may be in adults children United States. <h3>Design, Setting, Participants</h3> Using 2010-2011 Ambulatory Medical Care Survey Hospital Survey, annual numbers population-adjusted with 95% confidence...
Abstract Evidence-based guidelines for implementation and measurement of antibiotic stewardship interventions in inpatient populations including long-term care were prepared by a multidisciplinary expert panel the Infectious Diseases Society America Healthcare Epidemiology America. The included clinicians investigators representing internal medicine, emergency microbiology, critical care, surgery, epidemiology, pharmacy, adult pediatric infectious diseases specialties. These recommendations...
There is limited information on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing and infection among pediatric patients across the United States.To describe for SARS-CoV-2 epidemiology of infected patients.A retrospective cohort study was conducted using electronic health record data from 135 794 younger than 25 years who were tested January 1 through September 8, 2020. Data PEDSnet, a network 7 US systems, comprising 6.5 million primarily 11 states. analysis performed 8...
Although coronavirus disease 2019 (COVID-19) is mild in nearly all children, a small proportion of pediatric patients develop severe or critical illness. Guidance therefore needed regarding use agents with potential activity against acute respiratory syndrome 2 pediatrics.
Variation in medical practice has identified opportunities for quality improvement patient care. The degree of variation the use antibiotics children's hospitals is unknown.We conducted a retrospective cohort study 556,692 consecutive pediatric inpatient discharges from 40 freestanding between January 1, 2008, and December 31, 2008. We used Pediatric Health Information System to acquire data on antibiotic clinical diagnoses.Overall, 60% children received at least 1 agent during their...
Infections caused by antibiotic-resistant bacteria, including carbapenem-resistant Enterobacteriaceae, have increased in frequency, resulting significant patient morbidity and mortality. The Infectious Diseases Society of America continues to propose legislative, regulatory, funding solutions address this escalating crisis. This report updates the status development approval systemic antibiotics United States as late 2018. We performed a review published literature on-line clinical trials...
Background.The emergence of antibiotic-resistant organisms and the lack development new antimicrobials have made it imperative that additional strategies be developed to maintain effectiveness these existing antibiotics. The objective this study was describe impact a prospective-audit-with-feedback antimicrobial stewardship program (ASP) on antibiotic use in children's hospital.
Single-center evaluations of pediatric antimicrobial stewardship programs (ASPs) suggest that ASPs are effective in reducing and improving antibiotic prescribing, but studies limited. Our objective was to compare prescribing rates a group hospitals with formalized (ASP+) concurrent control without (ASP-).We evaluated the impact on over time measured by days therapy/1000 patient-days 31 freestanding children's (9 ASP+, 22 ASP-). We compared differences average use for all ASP+ ASP- from 2004...
Abstract Background Although coronavirus disease 2019 (COVID-19) is a mild infection in most children, small proportion develop severe or critical illness. Data describing agents with potential antiviral activity continue to expand such that updated guidance needed regarding use of these children. Methods A panel pediatric infectious diseases physicians and pharmacists from 20 geographically diverse North American institutions was convened. Through series teleconferences web-based surveys,...
Standard metrics for antimicrobial use consider volume but not spectrum of prescribing. We developed an antibiotic index (ASI) to classify commonly used antibiotics based on activity against important pathogens. The application this hospital reveals how tool enhances current stewardship metrics. Infect Control Hosp Epidemiol 2017;38:993–997
<h3>Importance</h3> Blood culture overuse in the pediatric intensive care unit (PICU) can lead to unnecessary antibiotic use and contribute resistance. Optimizing blood practices through diagnostic stewardship may reduce cultures antibiotics. <h3>Objective</h3> To evaluate association of a 14-site multidisciplinary PICU collaborative with rates, use, patient outcomes. <h3>Design, Setting, Participants</h3> This prospective quality improvement (QI) involved 14 PICUs across United States from...
We sought to describe the impact a clinical practice guideline (CPG) had on antibiotic management of children hospitalized with community-acquired pneumonia (CAP).We conducted retrospective study discharged patients from children's hospital an ICD-9-CM code for (480-486). Eligible were admitted July 8, 2007, through 9, 2009, 12 months before and after CAP CPG was introduced. Three-stage least squares regression analyses performed examine hypothesized simultaneous relationships, including our...
(Abstracted from JAMA 2016;315(17):1864–1873) Antibiotic-resistant infections, driven by inappropriate outpatient antibiotic use, are widespread in the United States. A number of initiatives, including Centers for Disease Control and Prevention's (CDC's) Get Smart: Know When Antibiotics Work, National Action Plan Combating Antibiotic-Resistant Bacteria, Healthcare Effectiveness Data Information Set (HEDIS) have been undertaken to promote appropriate use; however, fraction that is has be...
Background and objectives The Standardizing Care to Improve Outcomes in Pediatric ESRD Collaborative is a quality improvement initiative that aims reduce peritoneal dialysis–associated infections pediatric patients on chronic dialysis. Our were determine whether provider compliance with dialysis catheter care bundles was associated lower risk for infection at the individual patient level describe epidemiology, factors, outcomes peritonitis Collaborative. Design, setting, participants, &...
OBJECTIVE: Surgical site infections (SSIs) negatively affect patients and the health care system. National standards for SSI prevention do not exist in pediatric settings. We sought to reduce SSI-related harm by implementing a bundle through Solutions Patient Safety (SPS) national hospital engagement network. METHODS: Our study period was January 2011 December 2013. formed workgroup of content quality improvement experts. focused on 3 procedure types at high risk SSIs: cardiothoracic,...
Abstract Background Studies estimate that 30%–50% of antibiotics prescribed for hospitalized patients are inappropriate, but pediatric data limited. Characterization inappropriate prescribing practices children is needed to guide antimicrobial stewardship. Methods Cross-sectional analysis antibiotic at 32 children’s hospitals in the United States. Subjects included with ≥ 1 order 8:00 am on day per calendar quarter, over 6 quarters (quarter 3 2016–quarter 4 2017). Antimicrobial stewardship...
Antibiotic overuse contributes to antibiotic resistance, which is a threat public health. stewardship practice dedicated prescribing antibiotics only when necessary and, are considered necessary, promoting use of the appropriate agent(s), dose, duration, and route therapy optimize clinical outcomes while minimizing unintended consequences use. Because there differences in common infectious conditions, drug-specific considerations, evidence surrounding treatment recommendations (eg,...
OBJECTIVES: The objective of this study was to describe trends in antibiotic management for Staphylococcus aureus infections among hospitalized children from 1999 2008. METHODS: A retrospective conducted by using the Pediatric Health Information Systems database treatment inpatients with S infection at 25 children's hospitals United States. Patients who were admitted 2008 International Classification Diseases, Ninth Revision, Clinical Modification codes included. Trends use vancomycin,...