A5026543622- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Dialysis and Renal Disease Management
- Autoimmune Bullous Skin Diseases
- Ion Transport and Channel Regulation
- Platelet Disorders and Treatments
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Adolescent and Pediatric Healthcare
- Pregnancy and Medication Impact
- Blood Coagulation and Thrombosis Mechanisms
- Biomedical Research and Pathophysiology
- Hormonal Regulation and Hypertension
- Complement system in diseases
- Electrolyte and hormonal disorders
- Pharmaceutical studies and practices
- Acute Kidney Injury Research
- Pediatric Urology and Nephrology Studies
- Blood Pressure and Hypertension Studies
- Diabetes and associated disorders
- Muscle and Compartmental Disorders
- Central Venous Catheters and Hemodialysis
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Celiac Disease Research and Management
Nationwide Children's Hospital
2016-2025
The Ohio State University
2016-2025
Children's National
2004-2015
University of Michigan–Ann Arbor
1997-2009
C. S. Mott Children's Hospital
2000-2007
Children's Hospital of Michigan
1998-2007
Mayo Clinic in Florida
2007
Michigan Medicine
2000-2004
George Washington University
2004
Helen DeVos Children's Hospital
2004
The therapeutic approach to childhood nephrotic syndrome is based on a series of studies that began with an international collaborative effort sponsored by the International Study Kidney Disease in Children 1967. characteristics children presenting have changed over recent decades greater frequency challenging condition focal segmental glomerulosclerosis and prevalence obesity diabetes mellitus, which may be resistant glucocorticoids former exacerbated long-term glucocorticoid therapy latter...
Steroid-sensitive nephrotic syndrome (SSNS) accounts for >80% of cases in childhood. However, the etiology and pathogenesis SSNS remain obscure. Hypothesizing that coding variation may underlie risk, we conducted an exome array association study SSNS. We enrolled a discovery set 363 persons (214 South Asian children with 149 controls) genotyped them using Illumina HumanExome Beadchip. Four common single nucleotide polymorphisms (SNPs) HLA-DQA1 HLA-DQB1 (rs1129740, rs9273349, rs1071630,...
Children with nephrotic syndrome can develop life-threatening complications, including infection and thrombosis. While AKI is associated adverse outcomes in hospitalized children, little known about the epidemiology of children syndrome. The main objectives this study were to determine incidence, epidemiology, hospital a modern cohort syndrome.Records admitted 17 pediatric nephrology centers across North America from 2010 2012 reviewed. was classified using RIFLE definition.AKI occurred...
Hypothesis: Amino acid (AA) loss is not equivalent on continuous venovenous hemofiltration (CVVH) compared with hemodiafiltration (CVVHD). supplementation may be necessary to adjust for a greater clearance CVVH maintain nitrogen balance similar that of CVVHD. Objective: To compare AA losses and between CVVHD in children acute renal failure. Setting: Pediatric patients the pediatric intensive care unit tertiary referral center. Design: Prospective randomized crossover study consecutive who...
Abstract Background A reduction in the number of podocytes and podocyte density has been documented kidneys patients with diabetes mellitus. Additional studies have shown that injury loss occurs both diabetic animals humans. However, most examined relatively long-term changes not effects early after initiation diabetes. We hypothesized streptozotocin rats mice would result an this be prevented by antioxidants. Methods The per glomerular section glomeruli from (STZ)-diabetes mellitus was...
The convergence of three major trends in medicine, namely conversion to electronic health records (EHRs), prioritization translational research, and the need control healthcare expenditures, has created unprecedented interest opportunities develop systems that improve care while reducing costs. However, operationalizing a 'learning system' requires systematic changes have not yet been widely demonstrated clinical practice.We developed, implemented, evaluated model EHR-supported cohort 131...
Growth in children with chronic renal failure caused by polyuric, salt-wasting diseases may be hampered if ongoing sodium and water losses are not corrected. Twenty-four were treated polyuric insufficiency (CRI; creatinine clearance <65 ml/min per 1.73 m2) low-caloric-density, high-volume, sodium-supplemented feedings. Subsequent growth was compared that of two control groups: a national historic population from the US Renal Data System database (n = 42), literature 12). Members three groups...
Attachment of podocytes to the glomerular basement membrane is thought be mediated primarily by alpha 3/beta 1-integrins and cytoskeletal proteins including actin, talin, vinculin, alpha-actinin. We analyzed expression those molecules in rat glomeruli at several time points during induction podocyte foot process effacement nephrotic syndrome with puromycin aminonucleoside (PAN). PAN injection resulted marked alpha-actinin (40% increase vs. paired controls, P < 0.01), which clearly...
Cyclosporine (CsA) is effective in treating steroid-dependent (SDNS) and steroid-resistant (SRNS) nephrotic syndrome (NS) children, but because of the potential for chronic nephrotoxicity, its long-term use controversial. This study reports results CsA treatment 22 children with idiopathic NS. Indications included SDNS (N = 7) SRNS 15) children. Pre-CsA histology showed minimal change disease three patients, immunoglobulin M nephropathy (IgM) 14 focal segmental glomerulosclerosis (FSGS) five...
<i>Background:</i> Henoch-Schönlein Purpura (HSP) is a common childhood vasculitis with manifestations in numerous organ systems, including glomerulonephritis. Patients more severe HSP-associated glomerulonephritis may develop chronic renal failure. Currently, no widely accepted treatment protocols exist for patients significant involvement. <i>Methods:</i> We retrospectively reviewed the clinical courses of 12 children (mean age 9 years) HSP treated high-dose...
IntroductionNephrotic syndrome (NS) is a characterized by massive proteinuria, edema, hypoalbuminemia, and dyslipidemia. Glucocorticoids (GCs), the primary therapy for >60 years, are ineffective in approximately 50% of adults 20% children. Unfortunately, there no validated biomarkers able to predict steroid-resistant NS (SRNS) or define pathways regulating SRNS.MethodsWe performed proteomic analyses on paired pediatric patient plasma samples obtained both at disease presentation before...
Background FSGS is a heterogeneous diagnosis with guarded prognosis. Polymorphisms in the apolipoprotein L1 ( APOL1 ) gene are associated developing and faster progression to kidney failure affected patients. Better understanding natural history of patients risk alleles essential improve patient care support design interpretation interventional studies. The objective this study was evaluate quantitative association between disease interaction other clinical laboratory factors. Methods CureGN...