A5001640507- Renal Diseases and Glomerulopathies
- Blood Coagulation and Thrombosis Mechanisms
- Platelet Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Hemophilia Treatment and Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood properties and coagulation
- Blood groups and transfusion
- Chronic Kidney Disease and Diabetes
- Central Venous Catheters and Hemodialysis
- Antiplatelet Therapy and Cardiovascular Diseases
- Hormonal Regulation and Hypertension
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Peroxisome Proliferator-Activated Receptors
- Diabetes Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Blood disorders and treatments
- Complement system in diseases
- Iron Metabolism and Disorders
- Systemic Lupus Erythematosus Research
- Electrolyte and hormonal disorders
- Renin-Angiotensin System Studies
- Erythrocyte Function and Pathophysiology
- Autoimmune Bullous Skin Diseases
- Heparin-Induced Thrombocytopenia and Thrombosis
Nationwide Children's Hospital
2016-2025
The Ohio State University
2015-2024
The Ohio State University Wexner Medical Center
2022
RELX Group (United States)
2020
Harvard University
2001-2017
European Society for Blood and Marrow Transplantation
2015
Michigan State University
2015
Children's Healthcare of Atlanta
2015
Children's Hospital of Pittsburgh
2015
Indiana Hemophilia and Thrombosis Center
2015
Systemic delivery of mRNA-based therapeutics remains a challenging issue for preclinical and clinical studies. Here, we describe new lipid-like nanoparticles (TT-LLNs) developed through an orthogonal array design, which demonstrates improved efficiency mRNA encoding luciferase in vitro by over 350-fold with significantly reduced experimental workload. One optimized TT3 LLN, termed O-TT3 LLNs, was able to restore the human factor IX (hFIX) level normal physiological values FIX-knockout mice....
Abstract Background Pediatric venous thromboembolism (VTE) is an increasingly common problem. We hypothesized that VTE occurs most commonly in tertiary care settings and the pattern of associated illnesses may have changed from earlier reports. Methods The Kids' Inpatient Database 2006 was utilized to identify children ≤18 years old with in‐hospital VTE. Children were identified by presence thrombosis specific ICD‐9‐CM diagnosis or procedure codes. Remaining codes categorize patients acute...
Children with nephrotic syndrome can develop life-threatening complications, including infection and thrombosis. While AKI is associated adverse outcomes in hospitalized children, little known about the epidemiology of children syndrome. The main objectives this study were to determine incidence, epidemiology, hospital a modern cohort syndrome.Records admitted 17 pediatric nephrology centers across North America from 2010 2012 reviewed. was classified using RIFLE definition.AKI occurred...
Mutations in the gene encoding thrombomodulin (TM), a thrombin regulator, are suspected risk factors for venous and arterial thrombotic disease. We have previously described generation of TM Pro/Pro mice carrying mutation that disrupts TM-dependent activation protein C. Here, it is shown inbred C57BL/6J exhibit hypercoagulable state an increased susceptibility to thrombosis sepsis. Platelet thrombus growth after FeCl 3 -induced acute endothelial injury was accelerated mutant mice. Vascular...
Background and Purpose— There is little data regarding the cost of pediatric stroke care or elements that contribute to these costs. We examined costs for poststroke during first year after diagnosis compared with volume cerebral infarct level neurological functional outcome. Methods— identified 39 children who sustained nontraumatic ischemic hemorrhagic strokes confirmed diagnoses by review medical radiology records. Medical were tabulated stroke. Cerebral volumes measured from MRI CT...
Background: Hypoalbuminemia is a thrombotic disease risk biomarker. Albumin negative acute phase reactant and may thus be an indirect biomarker of thromboinflammation. However, nephrotic syndrome (resulting from non-inflammatory proteinuric glomerular disease) causes both hypoalbuminemia elevated risk. Hypofibrinolysis has been observed in published data suggest that albumin directly enhance fibrinolysis. These observations influence Objective: To test the hypothesis impairs Methods:...
Background Chronic kidney disease (CKD) is a leading cause of death, its progression driven by glomerular podocyte injury and loss, manifesting as proteinuria. Proteinuria includes loss coagulation zymogens, cofactors, inhibitors resulting in hypercoagulable state characterized enhanced thrombin generation. Both CKD proteinuria significantly increase the risk thromboembolic disease. Meanwhile, anticoagulant medications (which antagonize thereby prevent thromboembolism) have been shown to...
Ehlers-Danlos Syndrome (EDS) is caused by heritable collagen defects and may be associated with bleeding symptoms. Desmopressin has been described in case reports to decrease times these patients. This study sought assess time responsiveness desmopressin therapy a cohort of children EDS-associated manifestations. A retrospective chart review EDS referred for symptoms was utilized. Twenty-six were included; 19 (73%) had challenge. The mean 11.26 (+/-4.39) min, decreasing 5.95 (+/-2.41) min...
Nephrotic syndrome is characterized by massive proteinuria and injury of specialized glomerular epithelial cells called podocytes. Studies have shown that, whereas low-concentration thrombin may be cytoprotective, higher concentrations contribute to podocyte injury. We others demonstrated that ex vivo plasma generation enhanced during nephrosis, suggesting nephrotic progression. Moreover, nonspecific inhibition has been decrease in animal models. thus hypothesized contributes a...
Thrombotic disease, a major life-threatening complication of nephrotic syndrome, has been associated with proteinuria and hypoalbuminemia severity. However, it is not fully understood how disease severity correlates the acquired hypercoagulopathy syndrome. Without this knowledge, utility and/or as biomarkers thrombotic risk remains limited. Here, we show that two well established ex vivo assays, thrombin generation rotational thromboelastometry, are highly correlated in puromycin...
Abstract Congenital Amegakaryocytic Thrombocytopenia (CAMT) is a rare bone marrow failure syndrome that presents with isolated thrombocytopenia within the first year of life. Classic diagnostic findings reveal absent or significantly decreased megakaryocytes otherwise normal cellularity. We present newborn whose initial aspirate showed an appropriate number megakaryocytes. CAMT was subsequently diagnosed after molecular testing demonstrated mutation in thrombopoietin receptor. The presence...
Summary. There are no published reports investigating the ability of platelet function analyzer (PFA‐100 ® ) to detect presence delta‐granule storage pool deficiencies (δ‐PSPD), a common mild bleeding disorder. Prior studies PFA‐100 and congenital disorders have been limited by small numbers patients with variety disorders. We examined results in large paediatric patient population diagnosed specifically δ‐PSPD, determined relationship between electron microscopy (the gold standard for...