A5018966861- Renal Diseases and Glomerulopathies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood Coagulation and Thrombosis Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Chronic Kidney Disease and Diabetes
- Platelet Disorders and Treatments
- Acute Myocardial Infarction Research
- Blood properties and coagulation
- Peripheral Artery Disease Management
- RNA modifications and cancer
- Pediatric Pain Management Techniques
- Liver Disease Diagnosis and Treatment
- Renal and Vascular Pathologies
- Pain Management and Opioid Use
- Hemophilia Treatment and Research
- Hospital Admissions and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Genetic and Kidney Cyst Diseases
- Genomics and Rare Diseases
- Palliative Care and End-of-Life Issues
- Hepatitis Viruses Studies and Epidemiology
- Patient-Provider Communication in Healthcare
- Autoimmune Bullous Skin Diseases
- Cardiac tumors and thrombi
- Genetic factors in colorectal cancer
The Ohio State University
2020-2024
Indiana Hemophilia and Thrombosis Center
2023-2024
Nationwide Children's Hospital
2020-2023
The University of Texas MD Anderson Cancer Center
2019-2021
Background Chronic kidney disease (CKD) is a leading cause of death, its progression driven by glomerular podocyte injury and loss, manifesting as proteinuria. Proteinuria includes loss coagulation zymogens, cofactors, inhibitors resulting in hypercoagulable state characterized enhanced thrombin generation. Both CKD proteinuria significantly increase the risk thromboembolic disease. Meanwhile, anticoagulant medications (which antagonize thereby prevent thromboembolism) have been shown to...
Background: Approximately 10% of pediatric malignancies are secondary to germline alterations in cancer-predisposing genes. Checkpoint kinase 2 (CHEK2) loss-of-function variants have been reported cancer patients, but clinical phenotypes and outcomes poorly described. We present our single-institution experience oncology patients with CHEK2 alterations, including presentations outcomes. Methods: Pediatric were identified among those assessed by or translational research at the Institute for...
Abstract To diagnose schistosomiasis, past medical history review should include recent travel to or from an endemic area, a of elevated liver enzymes as well contact with contaminated sources water farm animals.
Palliative care is seeing cancer patients earlier in the disease trajectory with a multitude of chronic issues. Chronic non-malignant pain (CNMP) under-studied. In this prospective study, we examined prevalence and management CNMP seen at our supportive clinic for consultation. We systematically characterized each type Brief Pain Inventory (BPI) documented current treatments. The attending physician made diagnoses according to International Association Study (IASP) task force classification....
Background Patients with cancer prefer and positively perceive physicians who communicate face‐to‐face without the use of a computer. However, electronic health records (EHRs) in examination room remains practical necessity. On basis existing literature, authors developed tested an integration model, PRIME‐EHR, that focuses on best‐practice guidelines. To their knowledge, no randomized controlled trials (RCTs) have been conducted to test effectiveness such models. Methods In this...
Haemangiomas are the most common benign tumours of liver. Their origin lies in proliferation vascular endothelium. growth mechanism is by dilation. They considered giant when they exceed 5 cm at their greatest diameter. Very uncommon presentations surpass 15 cm; these known as enormous haemangiomas. We present a case 54-year-old woman with an haemangioma 30 A mass was her right upper quadrant along dull abdominal pain for several years. It unknown how long tumour had been developing. She...
Rationale & ObjectiveCardiovascular (CV) and thromboembolic (TE) events are known complications of glomerular disease (GD), but their incidence risk factors poorly characterized. This analysis describes CV TE outcomes in the Cure GlomeruloNephropathy (CureGN) Network.Study DesignProspective cohort study.Setting ParticipantsCureGN is a prospective study children adults with biopsy-proven minimal change (MCD), focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN), or IgA...
Abstract Background Arterial thrombosis (AT) is an increasingly recognized complication in pediatrics. Consensus clinical practice guidelines suggest immediate removal of the indwelling arterial catheter and a short course (5‐7 days) anticoagulation. The optimal duration modality antithrombotic therapy children are yet to be determined. Aims Describe treatment patterns outcomes pediatric patients with AT explore predictors for complete thrombus resolution or long‐term complications. Methods...
ABSTRACT Chronic kidney disease (CKD) is a leading cause of death, and its progression driven by glomerular podocyte injury loss, manifesting as proteinuria. Proteinuria includes urinary loss coagulation zymogens, cofactors, inhibitors. Importantly, both CKD proteinuria significantly increase the risk thromboembolic disease. Prior studies demonstrated that anticoagulants reduced in rats thrombin injured cultured podocytes. Herein we aimed to directly determine influence circulating...
Conclusion(s): Anticoagulation was often withheld in neonates with perceived lower thrombotic risk or higher bleeding risk, and expectative management not associated unfavorable outcomes.Further prospective studies are needed to tailor the treatment of neonatal VTE using a patient-centred approach.
Conclusion(s): Initiation of VTE chemoprophylaxis was inconsistently associated with established risk factors for HA-VTE and less likely in people bleeding or bleeding.Sex, race, insurance status were chemoprophylaxis, but those analyses not yet adjusted other than age.Implementation validated models could help optimize administration.
Prompt, appropriate coagulation factor replacement according to injury and bleeding severity in persons with haemophilia is required prevent acute long-term complications.
ABSTRACT Background Nephrotic syndrome is associated with an acquired hypercoagulopathy thought to drive its predisposition for venous thromboembolism. Previous studies have suggested that urinary antithrombin loss leading deficiency the primary mechanism underlying this hypercoagulopathy, but hypothesis has not been directly tested. The objectives of study were test influence levels on in nephrotic patient samples and perform meta-analyses evaluate likelihood patients. Design Samples from 3...