A5051348380- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Blood properties and coagulation
- Platelet Disorders and Treatments
- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
Nationwide Children's Hospital
2022-2025
University of Toledo
2024
Background: Hypoalbuminemia is a thrombotic disease risk biomarker. Albumin negative acute phase reactant and may thus be an indirect biomarker of thromboinflammation. However, nephrotic syndrome (resulting from non-inflammatory proteinuric glomerular disease) causes both hypoalbuminemia elevated risk. Hypofibrinolysis has been observed in published data suggest that albumin directly enhance fibrinolysis. These observations influence Objective: To test the hypothesis impairs Methods:...
Background Chronic kidney disease (CKD) is a leading cause of death, its progression driven by glomerular podocyte injury and loss, manifesting as proteinuria. Proteinuria includes loss coagulation zymogens, cofactors, inhibitors resulting in hypercoagulable state characterized enhanced thrombin generation. Both CKD proteinuria significantly increase the risk thromboembolic disease. Meanwhile, anticoagulant medications (which antagonize thereby prevent thromboembolism) have been shown to...
ABSTRACT Chronic kidney disease (CKD) is a leading cause of death, and its progression driven by glomerular podocyte injury loss, manifesting as proteinuria. Proteinuria includes urinary loss coagulation zymogens, cofactors, inhibitors. Importantly, both CKD proteinuria significantly increase the risk thromboembolic disease. Prior studies demonstrated that anticoagulants reduced in rats thrombin injured cultured podocytes. Herein we aimed to directly determine influence circulating...