A5082267579- Renal Diseases and Glomerulopathies
- Veterinary Equine Medical Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Muscle metabolism and nutrition
- Chronic Kidney Disease and Diabetes
- Renal function and acid-base balance
- Platelet Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Blood properties and coagulation
- Sports Performance and Training
- Hormonal Regulation and Hypertension
- Peroxisome Proliferator-Activated Receptors
- Pancreatic function and diabetes
- Venous Thromboembolism Diagnosis and Management
- Exercise and Physiological Responses
- Thermodynamic properties of mixtures
- Metabolism and Genetic Disorders
- Genetic and phenotypic traits in livestock
- Autoimmune Bullous Skin Diseases
- Thermoregulation and physiological responses
- Lipoproteins and Cardiovascular Health
- Cardiovascular and exercise physiology
- Cardiovascular Function and Risk Factors
Nationwide Children's Hospital
2016-2025
The Ohio State University Wexner Medical Center
2022
The Ohio State University
2011-2018
University of Guelph
2004-2010
Background: Insulin resistance (IR) has been widely recognized in humans, and more recently horses, but its underlying mechanisms are still not well understood. The translocation of glucose transporter 4 (GLUT4) to the cell surface is limiting step for uptake insulin‐sensitive tissues. Although downstream signaling pathways regulating GLUT defined, AS160 emerged as a potential key component. In addition, role GLUT12, one most identified GLUTs, during IR unknown. Hypothesis/Objectives: We...
Background: Hypoalbuminemia is a thrombotic disease risk biomarker. Albumin negative acute phase reactant and may thus be an indirect biomarker of thromboinflammation. However, nephrotic syndrome (resulting from non-inflammatory proteinuric glomerular disease) causes both hypoalbuminemia elevated risk. Hypofibrinolysis has been observed in published data suggest that albumin directly enhance fibrinolysis. These observations influence Objective: To test the hypothesis impairs Methods:...
Background Chronic kidney disease (CKD) is a leading cause of death, its progression driven by glomerular podocyte injury and loss, manifesting as proteinuria. Proteinuria includes loss coagulation zymogens, cofactors, inhibitors resulting in hypercoagulable state characterized enhanced thrombin generation. Both CKD proteinuria significantly increase the risk thromboembolic disease. Meanwhile, anticoagulant medications (which antagonize thereby prevent thromboembolism) have been shown to...
Nephrotic syndrome is characterized by massive proteinuria and injury of specialized glomerular epithelial cells called podocytes. Studies have shown that, whereas low-concentration thrombin may be cytoprotective, higher concentrations contribute to podocyte injury. We others demonstrated that ex vivo plasma generation enhanced during nephrosis, suggesting nephrotic progression. Moreover, nonspecific inhibition has been decrease in animal models. thus hypothesized contributes a...
Oral acetate supplementation enhances glycogen synthesis in some mammals. However, while is a significant energy source for skeletal muscle at rest horses, its effects on resynthesis are unknown. We hypothesized that administration of an oral sodium acetate–acetic acid solution with typical grain and hay meal after glycogen‐depleting exercise would result rapid appearance blood uptake by muscle. It was further taken up be converted to acetyl CoA (and acetylcarnitine), which metabolized CO 2...
Thrombotic disease, a major life-threatening complication of nephrotic syndrome, has been associated with proteinuria and hypoalbuminemia severity. However, it is not fully understood how disease severity correlates the acquired hypercoagulopathy syndrome. Without this knowledge, utility and/or as biomarkers thrombotic risk remains limited. Here, we show that two well established ex vivo assays, thrombin generation rotational thromboelastometry, are highly correlated in puromycin...
We hypothesized that postexercise rehydration using a hypotonic electrolyte solution will increase the rate of recovery whole body hydration, and this is associated with increased muscle glycogen in horses. Gluteus medius biopsies jugular venous blood were sampled from six exercise-conditioned Standardbreds on two separate occasions, at rest for 24 h following competitive exercise test (CET) designed to simulate speed endurance 3-day event. After CETs, horses given water ad libitum, either...
Abstract The present study characterized the fluid and electrolyte shifts that occur in Standardbred racehorses during recovery from high-intensity exercise. Jugular venous blood was sampled 13 Standardbreds racing condition, at rest for 2 h following a training workout. Total body water (TBW), extracellular volume (ECFV) plasma (PV) were measured using indicator dilution techniques (D O, thiocyanate Evans Blue, respectively). Changes TBW assessed measures of mass, changes PV ECFV calculated...
Background Thrombosis is a potentially life-threatening nephrotic syndrome (NS) complication. We have previously demonstrated that hypercoagulopathy proportional to NS severity in rat models and pioglitazone (Pio) reduces proteinuria both independently combination with methylprednisolone (MP), glucocorticoid (GC). However, the effect of these treatments on NS-associated remains unknown. thus sought determine ability Pio GC alleviate hypercoagulopathy. Methods Puromycin...
Abstract The present study used the physicochemical approach to characterize changes in acid–base status that occur Standardbred racehorses during recovery from high-intensity exercise. Jugular venous blood was sampled nine Standardbreds racing condition, at rest and for 2 h following a training workout. Plasma [H + ] increased 39.1±1.0 neq l −1 44.8±2.7 1 min of recovery. A decreased strong ion difference ([SID]) primary contributor immediately end exercise, while plasma weak concentration...
Summary Reasons for performing study: Standardbred and Thoroughbred racehorses around the world are tested performance enhancing substances. Among these blood alkalising substances that raise plasma pH total carbon dioxide (TCO 2 ) concentration. However, many horses have an elevated TCO due to dietary, environmental health concerns without having been administered substance. Objectives: The purposes of this study were determine acid‐base profile a cross section in racing/race training...
The present study determined the independent contributions of temperature, strong ion difference ([SID]), total weak acid concentration ([Atot]) and PCO2 to changes in arterial mixed venous [H+] carbon dioxide ([TCO2]) during 37 min moderate intensity exercise (~50% heart rate max) first 60 recovery. Six horses were fitted with indwelling carotid pulmonary artery (PA) catheters, had PA temperature measured, blood samples withdrawn for immediate analysis plasma gas concentrations. increase...
In human and animal clinical practice, multi-frequency bioelectrical impedance analysis (MF-BIA) is increasingly used as a diagnostic tool to assess hydration of intra-and extracellular fluid compartments. Accurate determination changes in status within individuals over time has remained problematic due the requirement for complete impedance-frequency relationships at points interest.To use MF-BIA 13 Standardbred racehorses 7 'endurance' research horses determine if could be track total body...
Sodium acetate (NaAcetate) has received some attention as an alkalinizing agent and possible alternative energy source for the horse, however effects of oral administration remain largely unknown. The present study used physicochemical approach to characterize changes in acid-base status occurring after NaAcetate/acetic acid (NAA) horses. Jugular venous blood was sampled from 9 exercise-conditioned horses on 2 separate occasions, at rest 24 h following a competition exercise test (CET)...
Abstract The present study used the physicochemical approach to characterize changes in acid–base status that occur Standardbreds after post-exercise electrolyte supplementation. Jugular venous blood was sampled from six conditioned on two separate occasions, at rest and for 24 h following a competitive exercise test (CET) designed simulate speed endurance of 3-day event. After CETs, horses were given water ad libitum either hypotonic commercial solution, via nasogastric tube followed by...
Oral electrolyte supplementation may influence acid-base state during exercise due to the intestinal absorption of administered water and electrolytes used mitigating sweat losses. This study examined effect pre-exercise (3 8 L) on plasma variables at rest, moderate intensity recovery. It was hypothesized that will result in improved compared alkalosis typical prolonged exercise. In randomized crossover fashion, four horses were 3 L or a hypotonic solution (PNW) intended replace losses,...
Abstract The present study used the physicochemical approach to characterize changes in plasma electrolyte and acid–base states that occur horses response feeding. Jugular venous blood was sampled every 0.5–2 h over a 24-h period from two groups ( n = 4 5) of Standardbreds fed mixed hay grain ration at 8 am 7 pm. One group studied October, one December. time course magnitude feeding responses differed between groups, morning evening meals. Feeding-induced variables occurred rapidly, within...
Venous thromboembolism (VTE) is the third most common cardiovascular disease and optimizing treatment essential. In this single-center pilot study, we sought to investigate effects of statins in addition anticoagulation patients with acute VTE. We enrolled over 18 an proximal lower extremity deep vein thrombosis or without pulmonary embolism. Patients were randomized alone (with either warfarin rivaroxaban) atorvastatin 40 mg daily followed for 9 months. The primary objective was determine...