A5047046365- Muscle metabolism and nutrition
- Cardiovascular and exercise physiology
- Adipose Tissue and Metabolism
- Sports Performance and Training
- Exercise and Physiological Responses
- Diet and metabolism studies
- Mitochondrial Function and Pathology
- Thermoregulation and physiological responses
- Sports injuries and prevention
- Metabolism and Genetic Disorders
- Coffee research and impacts
- Muscle activation and electromyography studies
- Biochemical effects in animals
- Lipid metabolism and biosynthesis
- Biochemical Acid Research Studies
- Winter Sports Injuries and Performance
- Metabolism, Diabetes, and Cancer
- High Altitude and Hypoxia
- Cardiovascular Effects of Exercise
- Pharmacology and Obesity Treatment
- Obesity, Physical Activity, Diet
- Fatty Acid Research and Health
- Aldose Reductase and Taurine
- Physical Activity and Health
- Diet, Metabolism, and Disease
University of Guelph
2015-2024
Queen's University
2010-2022
Lawrence University
2021
McMaster University
1999-2018
Maastricht University
2006-2018
Australian Catholic University
2018
University of Waterloo
1997-2018
University Health Network
2011
York University
2011
RMIT University
2011
Nutrition usually makes a small but potentially valuable contribution to successful performance in elite athletes, and dietary supplements can make minor this nutrition programme. Nonetheless, supplement use is widespread at all levels of sport. Products described as target different issues, including (1) the management micronutrient deficiencies, (2) supply convenient forms energy macronutrients, (3) provision direct benefits or (4) indirect such supporting intense training regimens. The...
Exercise training induces mitochondrial biogenesis, but the time course of molecular sequelae that accompany repetitive stimuli remains to be determined in human skeletal muscle. Therefore, throughout a seven-session, high-intensity interval period increased (12%), we examined responses (a) biogenesis and fusion fission proteins, (b) selected transcriptional mRNAs proteins Muscle biopsies were obtained 4 24 h after 1st, 3rd, 5th 7th session. PGC-1α mRNA was >10-fold 1st session returned...
This study examined the exercise responses of well-trained endurance athletes to various doses caffeine evaluate impact drug on metabolism and capacity. Subjects (n = 8) withdrew from all dietary sources for 48 h before each four tests. One hour they ingested capsules placebo or (3, 6, 9 mg/kg), rested quietly, then ran at 85% maximal O2 consumption voluntary exhaustion. Blood samples methylxanthine, catecholamine, glucose, lactate, free fatty acid, glycerol analyses were taken every 15 min....
Nutrition usually makes a small but potentially valuable contribution to successful performance in elite athletes, and dietary supplements can make minor this nutrition program. Nonetheless, supplement use is widespread at all levels of sport. Products described as target different issues, including the management micronutrient deficiencies, supply convenient forms energy macronutrients, provision direct benefits or indirect such supporting intense training regimens. The appropriate some...
Our aim was to examine the effects of seven high-intensity aerobic interval training (HIIT) sessions over 2 wk on skeletal muscle fuel content, mitochondrial enzyme activities, fatty acid transport proteins, peak O(2) consumption (Vo(2 peak)), and whole body metabolic, hormonal, cardiovascular responses exercise. Eight women (22.1 +/- 0.2 yr old, 65.0 2.2 kg wt, 2.36 0.24 l/min Vo(2 peak)) performed a peak) test 60-min cycling trial at approximately 60% before after training. Each session...
American College of Sport Medicine Roundtable on the physiological and health effects oral creatine supplementation. Med. Sci. Sports Exerc., Vol. 32, No. 3, pp. 706–717, 2000. Creatine (Cr) supplementation has become a common practice among professional, elite, collegiate, amateur, recreational athletes with expectation enhancing exercise performance. Research indicates that Cr can increase muscle phosphocreatine (PCr) content, but not in all individuals. A high dose 20 g·d−1 is to many...
The present study examined whether a high caffeine dose improved running and cycling performance altered substrate metabolism in well-trained runners. Seven trained competitive runners [maximal O2 uptake (VO2max) 72.6 +/- 1.5 ml.kg-1.min-1] completed four randomized double-blind exercise trials at approximately 85% VO2max; two to exhaustion exhaustion. Subjects ingested either placebo (PL, 9 mg/kg dextrose) or (CAF, mg/kg) 1 h before exercise. Endurance times were increased (P less than...
High-intensity aerobic interval training (HIIT) is a compromise between time-consuming moderate-intensity and sprint-interval requiring all-out efforts. However, there are few data regarding the ability of HIIT to increase capacities fat carbohydrate oxidation in skeletal muscle. Using untrained recreationally active individuals, we investigated muscle whole-body metabolic adaptations that occurred following 6 weeks (~1 h 10 × 4 min intervals at ~90% peak oxygen consumption (VO 2 ),...
We examined the effects of a high-caffeine dose on endurance performance and muscle acetyl group metabolism during prolonged exercise. Eight subjects cycled to exhaustion at approximately 80% maximal oxygen uptake (VO2max) 1 h after ingestion 9 mg/kg body wt dextrose (Pl) or caffeine (Caf). In Pl trial, biopsies were taken rest (1 postingestion) 15 min The Caf trial followed same protocol wk later, with an additional biopsy time corresponding exhaustion. significantly longer (96.2 +/- 8.8...
The time course for the activation of glycogen phosphorylase (Phos) and pyruvate dehydrogenase (PDH) their allosteric regulators was determined in human skeletal muscle during repeated bouts maximal exercise. Six subjects completed three 30-s isokinetic cycling separated by 4-min recovery periods. Muscle biopsies were taken at rest 6, 15, 30 s exercise 1 3. Phos rapidly activated within first 6 bout from 12% to 47% s. PDH increased 14% 48% 95% 15 1. reverted back basal values end bout,...
The relationships between muscle glycogenolysis, glycolysis, and H+ concentration were examined in eight subjects performing three 30-s bouts of maximal isokinetic cycling at 100 rpm. Bouts separated by 4 min rest, biopsies obtained before after 2 3. Total work decreased from 20.5 +/- 0.7 kJ bout 1 to 16.1 13.2 0.6 Glycogenolysis was 47.2 15.1 mmol glucosyl U/kg dry during 3, respectively. Lower accumulations pathway intermediates 3 confirmed a reduced glycolytic flux. In the done...
Muscle power and the associated metabolic changes in muscle were investigated eight male human subjects who performed four 30-s bouts of maximal isokinetic cycling at 100 rpm, with 4-min recovery intervals. In first bout peak total work (mean +/- SE) 1,626 102 W 20.83 1.18 kJ, respectively; glycogen decreased by 18.2 mmol/kg wet wt, lactate increased to 28.9 2.7 mmol/kg, there up 10-fold increases glycolytic intermediates. External 20% both second third exercise periods, but no further...
The aerobic work capacity of 11 highly trained runners was studied employing a double-blind design 1) before phlebotomy (C1), 2) following restoration normocythemia (C2), 3) after sham reinfusion 50 ml saline (sham), 4) autologous approximately 900 freeze-preserved blood (reinfusion), and 5) upon reestablishment control hematologic levels erythrocythemia (C3). There were no differences among C1, C2, sham, C3, but reinfusion, hemoglobin significantly elevated (15.7-16.7 g . 100 ml-1). Maximum...
This study investigated intramuscular triacylglycerol (IMTG) and glycogen utilisation, pyruvate dehydrogenase activation (PDHa) acetyl group accumulation during prolonged moderate intensity exercise. Seven endurance‐trained men cycled for 240 min at 57 % maximal oxygen consumption (V̇ O2,max ) duplicate muscle samples were obtained rest 10, 120 of We hypothesised that IMTG utilisation would be augmented 2‐4 h exercise, while PDHa decreased secondary to reduced metabolism. was measured on...
Intramuscular lipid pool turnover [triacylglycerols (TG), phospholipids (PL), mono- and diacylglycerols (MG, DG)] the oxidation of endogenous exogenous lipids were determined with pulse-chase studies in incubated muscles varied oxidative potential [soleus strips (SOL)--> epitrochlearis --> flexor digitorum brevis]. Incorporation palmitate into TG PL pools its linearly related to time concentration all muscles. Total incorporation (deposition oxidation) was greatest SOL. However,...
Mitochondrial fatty acid transport is a rate-limiting step in long chain (LCFA) oxidation. In rat skeletal muscle, the of LCFA at level mitochondria regulated by carnitine palmitoyltransferase I (CPTI) activity and content malonyl-CoA (M-CoA); however, this relationship not consistently observed humans. Recently, translocase (FAT)/CD36 was identified on isolated from human muscle found to be involved The present study investigated effects exercise (120 min cycling approximately 60%...
Five days of a high-fat diet while training, followed by 1 day carbohydrate (CHO) restoration, increases rates whole body fat oxidation and decreases CHO during aerobic cycling. The mechanisms responsible for these shifts in fuel are unknown but involve up- downregulation key regulatory enzymes the pathways skeletal muscle metabolism, respectively. This study measured PDH HSL activities before after 20 min cycling at 70% VO2peak sprinting 150% peak power output (PPO). Estimations...
Pyruvate dehydrogenase activity (PDHa) and acetyl group accumulation were examined in human skeletal muscle at rest during exercise after different diets. Five males cycled 75% of maximal O2 uptake (VO2 max) to exhaustion consuming a low-carbohydrate diet (LCD) for 3 days again 1-2 wk later the same duration high-carbohydrate (HCD) days. Resting PDHa was lower LCD (0.20 +/- 0.04 vs. 0.69 0.05 mmol.min-1.kg wet wt-1; P < 0.05) coincided with greater intramuscular acetyl-CoA-to-CoASH ratio,...
Abstract Implementation of a nutrition programme for team sports involves application scientific research together with the social skills necessary to work medicine and coaching staff. Both field court are characterized by intermittent activity requiring heavy reliance on dietary carbohydrate sources maintain replenish glycogen. Energy substrate demands high during pre-season training matches, moderate in competitive season. Dietary planning must include enough energy budget, while also...