A5011229086- Adipose Tissue and Metabolism
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Lipid metabolism and biosynthesis
- Muscle metabolism and nutrition
- Metabolism, Diabetes, and Cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Exercise and Physiological Responses
- RNA modifications and cancer
- Nutrition and Health in Aging
- Cancer, Hypoxia, and Metabolism
- Cardiovascular and exercise physiology
- Regulation of Appetite and Obesity
- Muscle Physiology and Disorders
- GDF15 and Related Biomarkers
- Peroxisome Proliferator-Activated Receptors
- Endoplasmic Reticulum Stress and Disease
- Mitochondrial Function and Pathology
- Metabolomics and Mass Spectrometry Studies
- Diet, Metabolism, and Disease
- Prostate Cancer Treatment and Research
- Cardiovascular Disease and Adiposity
The University of Melbourne
2009-2025
RMIT University
2003-2024
The University of Sydney
2024
Monash University
2013-2023
Mental Health Association of Westchester County
2023
Takeda (United States)
2023
Australian Regenerative Medicine Institute
2009-2021
Discovery Institute
2016-2020
St Vincents Institute of Medical Research
2006-2011
Cleveland Clinic Lerner College of Medicine
2011
Although interleukin-6 (IL-6) has been associated with insulin resistance, little is known regarding the effects of IL-6 on sensitivity in humans vivo. Here, we show that infusion increases glucose disposal without affecting complete suppression endogenous production during a hyperinsulinemic-euglycemic clamp healthy humans. Because skeletal muscle accounts for most insulin-stimulated vivo, examined mechanism(s) by which may affect metabolism using L6 myotubes. treatment increased fatty acid...
Patients with type 2 diabetes have reduced gene expression of heat shock protein (HSP) 72, which correlates insulin sensitivity. Heat therapy, activates HSP72, improves clinical parameters in these patients. Activation several inflammatory signaling proteins such as c-jun amino terminal kinase (JNK), inhibitor kappaB kinase, and tumor necrosis factor-alpha, can induce resistance, but HSP 72 block the induction molecules vitro. Accordingly, we examined whether activation HSP72 protect against...
PPAR gamma is required for fat cell development and the molecular target of antidiabetic thiazolidinediones (TZDs), which exert insulin-sensitizing effects in adipose tissue, skeletal muscle, liver. Unexpectedly, we found that inactivation macrophages results significant glucose intolerance plus muscle hepatic insulin resistance lean mice fed a normal diet. This phenotype was associated with increased expression inflammatory markers impaired signaling gamma-deficient secreted elevated levels...
<h3>BACKGROUND</h3> Particulate air pollution has been associated with excess deaths from, and increases in hospital admissions for, cardiovascular disease among older people. A study was undertaken to determine whether this may be a consequence of alterations the blood, secondary pulmonary inflammation caused by action fine particles on alveolar cells, repeatedly measuring haematological factors people relating them measurements exposure airborne particles. <h3>METHODS</h3> One hundred...
Skeletal muscle insulin resistance is associated with lipid accumulation, but whether due to reduced or enhanced flux of long-chain fatty acids into the mitochondria both controversial and unclear. We hypothesized that skeletal muscle-specific overexpression isoform carnitine palmitoyltransferase 1 (CPT1), enzyme controls entry acyl CoA mitochondria, would enhance rates acid oxidation improve action in high-fat diet insulin-resistant rats.Rats were fed a standard (chow) for 4 weeks. After 3...
Obesity is a major driver of cancer, especially hepatocellular carcinoma (HCC). The prevailing view that non-alcoholic steatohepatitis (NASH) and fibrosis or cirrhosis are required for HCC in obesity. Here, we report NASH obesity can be dissociated. We show the oxidative hepatic environment inactivates STAT-1 STAT-3 phosphatase T cell protein tyrosine (TCPTP) increases signaling. TCPTP deletion hepatocytes promoted recruitment ensuing as well obese C57BL/6 mice normally do not develop HCC....
Impaired estrogen action is associated with the metabolic syndrome in humans. We sought to determine whether impaired female C57Bl6 mice, produced by whole body Esr1 ablation, could recapitulate aspects of this syndrome, including inflammation, insulin resistance, and obesity. Indeed, we found that global knockout (KO) receptor (ER)α leads reduced oxygen uptake caloric expenditure compared wild-type (WT) mice. In addition, fasting insulin, leptin, PAI-1 levels were markedly elevated, whereas...
Dysregulated lipid metabolism and inflammation are linked to the development of insulin resistance in obesity, intracellular accumulation sphingolipid ceramide has been implicated these processes. Here, we explored role circulating on pathogenesis resistance. Ceramide transported LDL is elevated plasma obese patients with type 2 diabetes correlated but not degree obesity. Treating cultured myotubes containing promoted accrual cells was accompanied by reduced insulin-stimulated glucose...
Prostate cancer depends on fatty acid uptake and remodeling of the prostate lipidome, blocking impairs tumorigenesis.
Impaired estrogen receptor α (ERα) action promotes obesity and metabolic dysfunction in humans mice; however, the mechanisms underlying these phenotypes remain unknown. Considering that skeletal muscle is a primary tissue responsible for glucose disposal oxidative metabolism, we established reduced ERα expression associated with intolerance adiposity women female mice. To test this relationship, generated muscle-specific knockout (MERKO) homeostasis increased were paralleled by diminished...
Nonalcoholic fatty liver disease (NAFLD) comprises fat-accumulating conditions within hepatocytes that can cause severe damage and metabolic comorbidities. Studies suggest mitochondrial dysfunction contributes to its development progression the hepatic lipidome changes extensively in obesity NAFLD. To gain insight into relationship between lipid metabolism through different stages of NAFLD, we performed lipidomic analysis plasma biopsy samples from obese patients with nonalcoholic (NAFL) or...
Consumption of a Western diet rich in saturated fats is associated with obesity and insulin resistance. In some insulin-resistant phenotypes this accumulation skeletal muscle fatty acids. We examined the effects diets high acids (Sat) or n-6 polyunsaturated (PUFA) on acid metabolite whole-body sensitivity. Male Sprague-Dawley rats were fed chow (16% calories from fat, Con) (53%) Sat PUFA for 8 wk. Insulin sensitivity was assessed by fasting plasma glucose tolerance via an oral test. Muscle...
Hormone-sensitive lipase (HSL) is important for the degradation of triacylglycerol in adipose and muscle tissue, but tissue-specific regulation this enzyme not fully understood. We investigated effects adrenergic stimulation AMPK activation vitro circumstances where activity catecholamines are physiologically elevated humans vivo (during physical exercise) on HSL phosphorylation at Ser 563 660 , PKA regulatory sites, 565 site. In human experiments, skeletal muscle, subcutaneous venous blood...