Matthias Becker
A5063916697- Single-cell and spatial transcriptomics
- COVID-19 Clinical Research Studies
- Epigenetics and DNA Methylation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Blood disorders and treatments
- Cancer Genomics and Diagnostics
- Gene expression and cancer classification
- Genomics and Chromatin Dynamics
- Immune cells in cancer
- Bioinformatics and Genomic Networks
- MicroRNA in disease regulation
- Pluripotent Stem Cells Research
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- CRISPR and Genetic Engineering
- Mesenchymal stem cell research
- RNA modifications and cancer
- RNA Research and Splicing
- Estrogen and related hormone effects
- Cancer-related molecular mechanisms research
- Medical Image Segmentation Techniques
- 3D Printing in Biomedical Research
- Histone Deacetylase Inhibitors Research
- Cell Image Analysis Techniques
- Tissue Engineering and Regenerative Medicine
German Center for Neurodegenerative Diseases
2019-2025
University of Bonn
2017-2024
Goethe University Frankfurt
2000-2024
Goethe Institute
2024
Epigenomics (Germany)
2019-2022
University of Würzburg
2008-2022
University of Geneva
2013-2015
Battelle
2015
Universitätsklinikum Aachen
2010-2013
Massey University
2010-2013
Abstract Background The SARS-CoV-2 pandemic is currently leading to increasing numbers of COVID-19 patients all over the world. Clinical presentations range from asymptomatic, mild respiratory tract infection, severe cases with acute distress syndrome, failure, and death. Reports on a dysregulated immune system in call for better characterization understanding changes system. Methods In order dissect COVID-19-driven host responses, we performed RNA-seq whole blood cell transcriptomes...
Acute myeloid leukemia (AML) is a severe, mostly fatal hematopoietic malignancy. We were interested in whether transcriptomic-based machine learning could predict AML status without requiring expert input. Using 12,029 samples from 105 different studies, we present large-scale study of learning-based prediction which address key questions relating to the combination and transcriptomics their practical use. find data-driven, high-dimensional approaches—in multivariate signatures are learned...
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Abstract Symbiotic associations between plants and fungi are a dominant feature of many terrestrial ecosystems, yet relatively little is known about the signaling, associated transcriptome profiles, that define symbiotic metabolic state. Using Epichloë festucae-perennial ryegrass (Lolium perenne) association as model experimental system, we show an essential role for fungal stress-activated mitogen-activated protein kinase (sakA) in establishment maintenance this mutualistic interaction....
Despite its high prevalence, the cellular and molecular mechanisms of chronic obstructive pulmonary disease (COPD) are far from being understood. Here, we determine disease-related changes in compositions within alveolar space peripheral blood a cohort COPD patients controls. Myeloid cells were largest compartment with invading monocytes proliferating macrophages elevated COPD. Modeling cell-to-cell communication, signaling pathway usage, transcription factor binding predicts TGF-β1 to be...
During perinatal development, liver metabolism is tightly regulated to ensure energy supply for the newborn. Before birth, glycogen stored in hepatocytes and later metabolized glucose, meeting demands of neonate. Shortly after lipogenesis begins, driven by transcriptional activation enzymes involved fatty acid oxidation. These processes are thought be largely systemic insulin glucagon levels. However, role liver-derived local factors neonatal hepatocyte remains unexplored. Kupffer cells...
Abstract With the cost/yield-ratio of drug development becoming increasingly unfavourable, recent work has explored machine learning to accelerate early stages process. Given current success deep generative models across domains, we here investigated their application property-based proposal new small molecules for development. Specifically, trained a latent diffusion model— DrugDiff —paired with predictor guidance generate novel compounds variety desired molecular properties. The...
Neonates primarily rely on innate immune defense, yet their inflammatory responses are usually restricted compared to adults. This is controversially interpreted as a sign of immaturity or essential programming, increasing decreasing the risk sepsis, respectively. Here, combined transcriptomic, metabolic, and immunological studies in monocytes healthy individuals reveal an inverse ontogenetic shift metabolic pathway activities with age. Neonatal characterized by enhanced oxidative...
Adipose-derived mesenchymal stromal/stem cells (ASCs) represent a commonly used cell source for adipose tissue engineering. In this context, ASCs have routinely been cultured in conventional 2D culture and applied as single suspension seeding onto scaffold materials or direct injection. However, approach is associated with the loss of their intrinsic 3D microenvironment leads to impaired regenerative capacity cells. Thus, application self-assembled spheroids residing own matrix an attractive...
Abstract ‘Severe Acute Respiratory Syndrome - Coronavirus-2’ (SARS-CoV-2) infection causes Coronavirus Disease 2019 (COVID-19), a mild to moderate respiratory tract in the majority of patients. A subset patients, however, progresses severe disease and failure with acute distress syndrome (ARDS). Severe COVID-19 has been associated increased neutrophil counts dysregulated immune responses. The mechanisms protective immunity forms pathogenesis inflammation courses remain largely unclear. Here,...
We previously reported the discovery of a novel mammalian H1 linker histone termed H1FOO (formerly H1OO), replacement H1, expression which is restricted to growing/ maturing oocyte and zygote. The significance this pre-embryonic draws on its substantial orthologous conservation, singular structural attributes, selectivity for germ cell lineage, prolonged nucleosomal residence, apparent predominance among H1s. Herein, we report that intronic, single-copy, five-exon (> or =5301 base pair)...
Abstract Polycomb group (PcG) proteins comprise evolutionary conserved factors with essential functions for embryonic development and adult stem cells. PcG constitute two main multiprotein polycomb repressive complexes (PRC1 PRC2) that operate in a hierarchical manner to silence gene transcription. Functionally distinct PRC1 are defined by RING finger protein (Pcgf) paralogs. So far, six Pcgf paralogs (Pcgf1–6) have been identified as defining components of different PCR1-type complexes....