A5014475022- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- Renin-Angiotensin System Studies
- Liver physiology and pathology
- Hormonal Regulation and Hypertension
- Cytokine Signaling Pathways and Interactions
- Neuroendocrine Tumor Research Advances
- Amino Acid Enzymes and Metabolism
- Probiotics and Fermented Foods
- Receptor Mechanisms and Signaling
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Chronic Lymphocytic Leukemia Research
- Pancreatic and Hepatic Oncology Research
- CAR-T cell therapy research
- Cancer Treatment and Pharmacology
- Lung Cancer Treatments and Mutations
- Immunodeficiency and Autoimmune Disorders
- Ferrocene Chemistry and Applications
Charité - Universitätsmedizin Berlin
2004-2024
Bundeswehrkrankenhaus
2024
University Hospital Ulm
2021
German Rheumatism Research Centre
2014-2020
Leibniz Association
2014-2019
Humboldt-Universität zu Berlin
2017
Freie Universität Berlin
2017
Partners In Health
2017
Ludwig-Maximilians-Universität München
2013
Queen's Medical Centre
2011
Secretion of the immunosuppressive cytokine interleukin (IL) 10 by effector T cells is an essential mechanism self-limitation during infection. However, transcriptional regulation IL-10 expression in proinflammatory helper (Th) 1 insufficiently understood. We report a crucial role for regulator Blimp-1, induced IL-12 STAT4-dependent manner, controlling Th1 cells. Blimp-1 deficiency led to excessive inflammation Toxoplasma gondii infection with increased mortality. production from was...
Compelling evidence demonstrates the pivotal role of commensal intestinal microbiota in host physiology and detrimental effects its perturbations following antibiotic treatment. Aim this study was to investigate impact antibiotics induced depletion subsequent restoration composition on murine mucosal systemic immunity. To address conventional C57BL/6j mice were subjected broad-spectrum treatment (ABx) for eight weeks. Restoration by peroral fecal transplantation (FMT) led reestablishment...
T follicular helper (T
Ceftriaxone has been reported to reduce neuronal damage in amyotrophic lateral sclerosis and an in-vitro model of ischaemia through increased expression activity the glutamate transporter, GLT1. We tested effects ceftriaxone on mortality, neurological outcome, infarct size experimental stroke rats looked for underlying mechanisms.Male normotensive Wistar received (200 mg/kg intraperitoneal) as a single injection 90 min after middle cerebral artery occlusion (90 with reperfusion). Forty-eight...
Objectives Inhibition of (pro)renin receptor activation was demonstrated to inhibit or even abolish the development end-organ damage in animal models. The new renin inhibitor, aliskiren, markedly increases plasma concentration ligands prorenin and patients. effects inhibitors on signal transduction cascade are currently unknown. Results Our results indicate that were equally potent by decreasing mRNA, increasing phosphatidylinositol-3 kinase p85α mRNA augmenting viable cell number,...
Adequate termination of an immune response is as important the induction appropriate response. CD46, a regulator complement activity, promotes T cell activation and differentiation towards regulatory Tr1 phenotype. This pathway defective in patients with MS, asthma rheumatoid arthritis, underlying its importance controlling function need to understand mechanisms. CD46 has two cytoplasmic tails, Cyt1 Cyt2, derived from alternative splicing, which are co-expressed all nucleated human cells....
Repeatedly activated T helper 1 (Th1) cells present during chronic inflammation can efficiently adapt to the inflammatory milieu, for example, by expressing transcription factor Twist1, which limits immunopathology caused Th1 cells. Here, we show that in repeatedly murine cells, Twist1 and T‐bet induce expression of microRNA‐148a (miR‐148a). miR‐148a regulates proapoptotic gene Bim , resulting a decreased Bim/Bcl2 ratio. Inhibition antagomirs increases Bim, leading enhanced apoptosis....
There is compelling evidence linking the commensal intestinal microbiota with host health and, in turn, antibiotic induced perturbations of composition distinct pathologies. Despite attractiveness probiotic therapy as a tool to beneficially alter microbiota, its immunological effects are still incompletely understood. The aim present study was assess efficacy formulation VSL#3 consisting eight bacterial species (including Streptococcus thermophilus, Bifidobacterium breve, B. longum,...
HIV/AIDS remains the second most common cause of death in low and middle-income countries (LMICs), only 34% eligible patients Africa received antiretroviral therapy (ART) 2013. This study investigated impact ART decentralization on patient enrollment retention rural Malawi. We reviewed electronic medical records registered Neno District program from August 1, 2006, when first became available, through December 31, used GPS data to calculate patient-level distance care, examined number annual...
Under homeostasis, liver sinusoidal endothelial cells (LSECs) shift intrahepatic T‐cell responses towards tolerance. However, the role of LSECs in regulation T‐cell‐induced inflammation is less clear. Here, we studied capacity to modulate pro‐inflammatory Th1‐cell differentiation mice. Using vitro co‐culture systems and subsequent cytokine analysis, showed that induced high amounts anti‐inflammatory IL‐10 developing Th1 cells. These LSEC‐stimulated had no vivo but instead actively suppressed...
The essential role of the intestinal microbiota in well-functioning host immunity necessitates investigation species-specific impacts on this interplay. Aim study was to examine ability defined Gram-positive and Gram-negative commensal bacterial species, namely Escherichia coli Lactobacillus johnsonii, respectively, restore immune functions mice that were immunosuppressed by antibiotics-induced depletion. Conventional subjected broad-spectrum antibiotic treatment for 8 weeks perorally...
Immunosuppressive Interleukin (IL)-10 production by pro-inflammatory CD4+ T cells is a central self-regulatory function to limit aberrant inflammation. Still, the molecular mediators controlling IL-10 expression in human are largely undefined. Here, we identify Notch/STAT3 signaling-module as universal switch induce across naïve and major effector cell subsets. induction was transient, jointly controlled transcription factors Blimp-1/c-Maf accompanied upregulation of several co-inhibitory...
RORγt+ group 3 innate lymphoid cells (ILC3s) maintain intestinal homeostasis through secretion of type cytokines such as interleukin (IL)-17 and IL-22. However, CCR6- ILC3s additionally co-express T-bet allowing for the acquisition 1 effector functions. While controls programming ILC3s, molecular mechanisms governing are undefined. Here, we identify c-Maf a crucial negative regulator murine T-bet+ ILC3s. Phenotypic transcriptomic profiling c-Maf-deficient revealed hyper differentiation...
Objectives: IgG4-related disease (IgG4-RD) is a chronic fibro-inflammatory disorder affecting virtually any organ. Type 1 autoimmune (type AIP) its pancreatic manifestation. To date, steroids are considered the first-line pancreatitis treatment. The CD20-binding antibody rituximab (RTX) appears promising steroid-sparing therapy, although long-term data lacking. We aimed to bridge this gap with cohort of IgG4-RD patients treated RTX and assess potential value Responder Index (RI) as...
The primary function of the small intestine (SI) is to absorb nutrients maintain whole-body energy homeostasis. Enterocytes are major epithelial cell type facilitating nutrient sensing and uptake. However, molecular regulators governing enterocytes have remained undefined. Here, we identify c-Maf as an enterocyte-specific transcription factor within SI epithelium. expression was determined by opposing Noggin/BMP signals overlapped with zonated enrichment transporters in mid-villus region....
Abstract Increases in the intracellular levels of glutathione (GSH) cancer cells have been implicated development acquired resistance to platinum antitumor agents. On other hand, little information is available on relationships between GSH non‐treated and their response complexes. The present work investigated for possible correlations concentrations GSH/GSSG 14 human cell lines growing vitro growth inhibitory activities cis platin, carboplatin, oxaliplatin, d, l‐trans ‐1,...
A constitutive and dynamic interaction between tumor cells their surrounding stroma is a prerequisite for invasion metastasis. Fibroblasts myofibroblasts (collectively called cancer associated fibroblasts, CAFs) often represent the major cellular components of stroma. Tumor secret different growth factors which induce CAFs proliferation differentiation, and, consequently, secrete chemokines, cytokines or cell In this study we showed here that from breast surgical specimens significantly...