A5065149586- Asthma and respiratory diseases
- Occupational exposure and asthma
- Allergic Rhinitis and Sensitization
- Air Quality and Health Impacts
- Occupational and environmental lung diseases
- IL-33, ST2, and ILC Pathways
- Pediatric health and respiratory diseases
- Immune Response and Inflammation
- Cancer Immunotherapy and Biomarkers
- Air Quality Monitoring and Forecasting
- Indoor Air Quality and Microbial Exposure
- Occupational Health and Safety Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immune responses and vaccinations
- Food Allergy and Anaphylaxis Research
- Inhalation and Respiratory Drug Delivery
- Energy and Environment Impacts
- Cytokine Signaling Pathways and Interactions
- Respiratory and Cough-Related Research
- Fungal Biology and Applications
- Neonatal Respiratory Health Research
- Cancer Cells and Metastasis
- Cancer, Stress, Anesthesia, and Immune Response
- Statistical Methods in Epidemiology
- Effects and risks of endocrine disrupting chemicals
Université de Lille
2020-2024
Centre Hospitalier Universitaire de Lille
2020-2024
Centre National de la Recherche Scientifique
2020-2024
Inserm
2020-2024
Institut Pasteur de Lille
2020-2024
Center for Infection and Immunity of Lille
2020-2024
Kiel University
2022
Universitat Autònoma de Barcelona
2013-2021
Vall d'Hebron Hospital Universitari
2013-2020
Vall d'Hebron Institut de Recerca
2013-2019
Malignant progression in cancer requires populations of tumor-initiating cells (TICs) endowed with unlimited self renewal, survival under stress, and establishment distant metastases. Additionally, the acquisition invasive properties driven by epithelial-mesenchymal transition (EMT) is critical for evolution neoplastic into fully metastatic populations. Here, we characterize 2 human cellular models derived from prostate bladder cell lines to better understand relationship between TIC EMT...
Immunosuppressive Interleukin (IL)-10 production by pro-inflammatory CD4+ T cells is a central self-regulatory function to limit aberrant inflammation. Still, the molecular mediators controlling IL-10 expression in human are largely undefined. Here, we identify Notch/STAT3 signaling-module as universal switch induce across naïve and major effector cell subsets. induction was transient, jointly controlled transcription factors Blimp-1/c-Maf accompanied upregulation of several co-inhibitory...
Exposure to soybean allergens has been linked asthma outbreaks. diesel exhaust particles (DEP) associated with an increase in the risk of and exacerbation; however, both cases underlying mechanisms remain poorly understood, as does possible interaction between two entities.To investigate how combination DEP can affect induction or exacerbation a murine model.BALB/c mice received intranasal instillations saline, 3 5 mg protein/ml hull extract (SHE), one these three solutions DEP. Airway...
Background House dust mite is the most frequent trigger of allergic asthma, with innate and adaptive immune mechanisms playing critical roles in outcomes. We recently identified nucleotide-binding oligomerisation domain 1 (NOD1)/receptor-interacting serine/threonine protein kinase 2 (RIPK2) signalling pathway as a relevant contributor to murine house mite-induced asthma. This study aimed evaluate effectiveness pharmacological RIPK2 inhibitor administered locally preventive therapeutic...
It is believed that intestinal recruitment of monocytes from Crohn's Disease (CD) patients who carry NOD2 risk alleles may repeatedly give rise to pathogenic macrophages. We investigated an alternative possibility rather inhibit their differentiation intravasating monocytes.
Demonstrating antigen exposure is critical in the diagnosis and management of hypersensitivity pneumonitis.• An immunochromatographic test compared with an ELISA method for measurement pigeon antigens environment.• The described was highly consistent validated does not require specific skills.• This may prove to be a useful tool predicting progression birdrelated pneumonitis.
Background Determining soy aeroallergens levels is extremely important in the assessment of health risks due to these airborne substances. Currently, exposure environment monitored using enzyme immunoassays (EIA) which must be evaluated a specialized laboratory by skilled personnel. Objective To describe development and performance rapid immunochromatography assay for detection environmental samples. Methods A test strip gold labeled anti-soy hull low molecular weight extract (SHLMWE)...
Nucleotide-binding oligomerization domain 2 (NOD2) recognizes pathogens associated with the development of asthma. Moreover, NOD2 adjuvants are used in vaccine design to boost immune responses. Muramyl di-peptide (MDP) is a ligand, which able promote Th2/Th17 Furthermore, polymorphisms receptor allergy and asthma development. This study aimed evaluate if MDP given as an adjuvant during allergen sensitization may worsen We mouse model Th2/Th17-type allergic neutrophil airway inflammation...
Introduction: The seven-item QEAS-7 questionnaire (exposure to asbestos questionnaire) has been designed as a useful and simple tool establish the probability of exposure asbestos. objective present study is validate following recommended methodology. Methods: was prospectively administered 90 subjects with without asbestos-related disease (ARD), on two consecutive occasions by independent researchers. Logical content validity evaluated committee experts construct through hypothesis testing....
Signal transducer and activator of transcription 3 (STAT3) is a latent factor with pleiotropic roles in hematopoietic non-hematopoietic cells, that regulates gene expression downstream cell surface cytokine hormone receptors.Heterozygous germline loss-of-function STAT3 mutations lead to the primary immunodeficiency hyper-IgE syndrome (HIES) while somatic gain-of-function recur human solid organ malignancies non-Hodgkin lymphoma.Recently, heterozygous gain-offunction were shown result...
<b>Introduction:</b> Exposure to soybean allergens has been linked the onset of asthma outbreaks and cases occupational asthma. Conventional murine models generate an allergic response or airway inflammation by intraperitoneal administration allergen with adjuvant. Therefore they are limited design allow study immune mechanism that underlies behind due soybean. <b>Aim:</b> The aim this is standardize a model soybean-induced effect exposure these allergens. <b>Methods:</b> 6 weeks female...
<b>Introduction:</b> Exposure to soybean allergens and diesel exhaust particles (DEPs) have been linked the onset of asthma exacerbations. <b>Aim:</b> Study how combination DEPs can affect induction or exacerbation in a murine model. <b>Methods:</b> Female BALB/c mice received intranasal instillations saline, 3 5 mg protein/ml hull extract (SHE), consecutive days (3 weeks). Three per week solutions were administered with 150 µg DEPs. Airway hyperresponsiveness (AHR) was assessed using...
<b>Aim:</b> To study a representative sample of patients with lung cancer in Spain order to assess the involvement asbestos as causal factor. <b>Methods:</b> We present data from first 60 diagnosed and undergoing resection surgery at five hospitals Spain: Terrassa (Barcelona) (n = 22), Alicante 12), Biscay 15, two hospitals) Navarre 11). All were administered specific questionnaire regarding their exposure asbestos. In all individuals, tissue samples 2 cm<sup>3</sup> collected. For analysis...