A5090224526- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Organ Transplantation Techniques and Outcomes
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Neonatal Health and Biochemistry
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal Transplantation Outcomes and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Pharmacogenetics and Drug Metabolism
- Hepatitis Viruses Studies and Epidemiology
- Immune Cell Function and Interaction
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genetic factors in colorectal cancer
- Liver physiology and pathology
- Drug Transport and Resistance Mechanisms
- Systemic Lupus Erythematosus Research
- Pancreatitis Pathology and Treatment
- Cancer therapeutics and mechanisms
- Neuroendocrine Tumor Research Advances
- Immunotherapy and Immune Responses
- Metabolism and Genetic Disorders
- Colorectal Cancer Screening and Detection
University Hospital Bonn
2016-2025
University of Bonn
2015-2024
Intelligent Transport Systems Niedersachsen
2024
German Center for Infection Research
2014-2023
Heinrich Heine University Düsseldorf
2016-2023
National Center for Tumor Diseases
2020-2022
Society of Interventional Radiology
2021
Düsseldorf University Hospital
2016-2020
KfH Kuratorium für Dialyse und Nierentransplantation
2020
Medizinische Hochschule Hannover
2008-2019
Acetaminophen (APAP, paracetamol) poisoning is a leading cause of acute liver failure (ALF) in humans and induces hepatocyte necrosis, followed by activation the innate immune system, further aggravating injury. The role infiltrating monocytes during early phase ALF still ambiguous. Upon experimental APAP overdose mice, monocyte-derived macrophages (MoMFs) massively accumulated injured within 12-24 hours, whereas number tissue-resident (Kupffer cells) decreased. Influx MoMFs dependent on...
UDP-glucuronosyltransferases (UGT) catalyze the conjugation of lipophilic exobiotic and endobiotic compounds, which leads to excretion hydrophilic glucuronides via bile or urine. By a mechanism exon sharing, transcripts individual first cassettes located at 5' end human UGT1A locus are spliced exons 2-5, leading expression least nine UGT genes. Recently, tissue-specific has been demonstrated in extrahepatic tissue, identification UGT1A7 UGT1A10 mRNA (Strassburg, C. P., Oldhafer, K., Manns,...
Family 1 UDP-glucuronosyltransferases (UGTs) (UGT1A) are encoded by a locus that predicts the existence of at least nine individual proteins. The different proteins generated exon-sharing, which results in production family contain identical, 245-amino acid, carboxyl-terminal domains and an amino-terminal region approximately 280 amino acids. diversity the<i>UGT1A</i> suggests complex regulation, most likely designed to account for variable specific glucuronidation requirements. However,...
Background and aims: The liver represents one of the major sites human glucuronidation. Many therapeutic drugs are substrates for UDP-glucuronosyltransferases (UGT) leading to formation usually inactive glucuronides. Hepatic glucuronidation undergoes significant changes during fetal neonatal development requiring age adapted drug therapy. Regulation individual UGT genes hepatic has not been defined. Subjects methods: Expression 13 activities were analysed in 16 paediatric samples (aged 7–24...
Autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) are immune-mediated chronic inflammatory diseases of the liver unknown etiology. Genetic factors appear to be involved in pathogenesis both diseases. 1,25-Dihydroxyvitamin D 3 has been implicated as an immunomodulator, which acts through its own receptor (VDR). Polymorphisms VDR have linked a variety autoimmune In this study polymorphisms were analyzed 123 patients with AIH, 74 PBC, 214 controls. assessed by BsmI, TaqI, ApaI, Fok...
UDP-glucuronosyltransferases (UGTs) convert dietary constituents, drugs, and environmental mutagens to inactive hydrophilic glucuronides. Recent studies have shown that the expression of <i>UGT1</i> <i>UGT2</i> gene families is regulated in a tissue-specific fashion. Human small intestine represents major site resorption constituents orally administered drugs plays an important role extrahepatic UGT directed metabolism. Expression 13 <i>UGT1A</i> <i>UGT2B</i>genes coupled with functional...
Chronic hepatitis C virus (HCV) infection is characterized by inflammatory liver damage and associated with a high risk of development cirrhosis hepatocellular carcinoma. Although histological examination biopsies currently the gold standard for detection early damage, there strong need better noninvasive methods. We recently demonstrated that proapoptotic activation caspases considerably enhanced in sections from HCV-infected tissue, suggesting an important role apoptosis damage. Here, we...
Hepatitis E virus (HEV) infection induces self-limiting liver disease in immunocompetent individuals. Cases of chronic hepatitis have recently been identified organ transplant recipients. We questioned if plays a role graft after transplantation low endemic area. Two hundred twenty-six recipients, 129 nontransplanted patients with disease, and 108 healthy controls were tested for HEV antibodies. RNA was investigated all sera from transplanted patients. antibodies detected 1 control (1%), 4...
Abstract Non-alcoholic steatohepatitis (NASH) is characterised by hepatic steatosis, inflammation and fibrosis, which might progress to cirrhosis. Human NASH associated with metabolic syndrome (MS). Currently, rodent models either lack significant fibrosis or MS. ApoE −/− mice are a MS model used in cardiovascular research. The aim of this work was establish characterise novel mouse wild-type (wt) were fed western-diet (WD), methionine-choline-deficient-diet (MCD) normal chow. Liver...
Muscle mass seems to be a prognostic marker in patients with liver cirrhosis. However, reported methods quantify muscle are heterogeneous, consented cutoff values missing, and most studies have used computed tomography. This study evaluated fat-free area (FFMA) as of sarcopenia using magnetic resonance imaging (MRI) decompensated cirrhosis transjugular intrahepatic portosystemic shunt (TIPS). The total erector spinae the intramuscular fat tissue were measured subtracted calculate FFMA 116 by...