Gernot Marx
A5064776829- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Hemodynamic Monitoring and Therapy
- Intensive Care Unit Cognitive Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 Clinical Research Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Long-Term Effects of COVID-19
- Cardiac Arrest and Resuscitation
- Renal function and acid-base balance
- Nosocomial Infections in ICU
- Medical Practices and Rehabilitation
- Anesthesia and Neurotoxicity Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Clinical practice guidelines implementation
- Biomedical and Chemical Research
- Health and Medical Studies
- Acute Kidney Injury Research
- Non-Invasive Vital Sign Monitoring
- Machine Learning in Healthcare
- Electrolyte and hormonal disorders
- Thermal Regulation in Medicine
- Mechanical Circulatory Support Devices
- SARS-CoV-2 and COVID-19 Research
- Immune Response and Inflammation
Universitätsklinikum Aachen
2016-2025
RWTH Aachen University
2016-2025
German Medical Association
2024
Inform (Germany)
2024
Westfälische Hochschule
2020-2022
University Hospital Bonn
2016-2022
Deutsche Gesellschaft für Anästhesiologie und Intensivmedizin
2006-2021
Deutsche Interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin
2020-2021
Heidelberg University
2021
Ziekenhuis Oost-Limburg
2021
Acute kidney injury (AKI) can evolve quickly and clinical measures of function often fail to detect AKI at a time when interventions are likely provide benefit. Identifying early markers damage has been difficult due the complex nature human AKI, in which multiple etiologies exist. The objective this study was identify validate novel biomarkers AKI.
Background Nationwide, unbiased, and unselected data of hospitalised patients with COVID-19 are scarce. Our aim was to provide a detailed account case characteristics, resource use, outcomes in Germany, where the health-care system has not been overwhelmed by pandemic.In this observational study, adult confirmed diagnosis, who were admitted hospital Germany between Feb 26 April 19, 2020, for whom complete course available (ie, patient discharged or died hospital) included study cohort....
Fast and reliable detection of patients with severe heterogeneous illnesses is a major goal precision medicine1,2. Patients leukaemia can be identified using machine learning on the basis their blood transcriptomes3. However, there an increasing divide between what technically possible allowed, because privacy legislation4,5. Here, to facilitate integration any medical data from owner worldwide without violating laws, we introduce Swarm Learning-a decentralized machine-learning approach that...
Objective We report on the effect of hemoadsorption therapy to reduce cytokines in septic patients with respiratory failure. Methods This was a randomized, controlled, open-label, multicenter trial. Mechanically ventilated severe sepsis or shock and acute lung injury distress syndrome were eligible for study inclusion. Patients randomly assigned either CytoSorb hemoperfusion 6 hours per day up 7 consecutive days (treatment), no (control). Primary outcome change normalized IL-6-serum...
Acetaminophen (APAP, paracetamol) poisoning is a leading cause of acute liver failure (ALF) in humans and induces hepatocyte necrosis, followed by activation the innate immune system, further aggravating injury. The role infiltrating monocytes during early phase ALF still ambiguous. Upon experimental APAP overdose mice, monocyte-derived macrophages (MoMFs) massively accumulated injured within 12-24 hours, whereas number tissue-resident (Kupffer cells) decreased. Influx MoMFs dependent on...
n December 2019, an acute lung disease of unknown origin broke out in the Chinese province Hubei.On 7 January 2020, scientists succeeded isolating a new coronavirus (severe respiratory syndrome corona virus 2, SARS-CoV-2) and identifying it as cause virus-induced pneumonia (1, 2).In line with WHO's definition disease, is now referred to 2019 (COVID-19) and, person-to-person droplet infection, rapidly spreading worldwide (3).The clinical manifestation infection highly variable, ranging from...
High-dose intravenous administration of sodium selenite has been proposed to improve outcome in sepsis by attenuating oxidative stress. Procalcitonin-guided antimicrobial therapy may hasten the diagnosis sepsis, but effect on is unclear.To determine whether high-dose treatment and procalcitonin-guided anti-infectious patients with severe affect mortality.The Placebo-Controlled Trial Sodium Selenite Procalcitonin Guided Antimicrobial Therapy Severe Sepsis (SISPCT), a multicenter, randomized,...
Although current guidelines suggest the use of regional citrate anticoagulation (which involves addition a solution to blood before filter extracorporeal dialysis circuit) as first-line treatment for continuous kidney replacement therapy in critically ill patients, evidence this recommendation is based on few clinical trials and meta-analyses.To determine effect anticoagulation, compared with systemic heparin life span mortality.A parallel-group, randomized multicenter trial 26 centers...
Adjunctive hydrocortisone therapy is suggested by the Surviving Sepsis Campaign in refractory septic shock only. The efficacy of patients with severe sepsis without remains controversial.To determine whether prevents development shock.Double-blind, randomized clinical trial conducted from January 13, 2009, to August 27, 2013, a follow-up 180 days until February 23, 2014. was performed 34 intermediate or intensive care units university and community hospitals Germany, it included 380 adult...
Early appropriate antimicrobial therapy leads to lower mortality rates associated with severe sepsis. The role of empirical combination comprising at least 2 antibiotics different mechanisms remains controversial.To compare the effect moxifloxacin and meropenem alone on sepsis-related organ dysfunction.A randomized, open-label, parallel-group trial 600 patients who fulfilled criteria for sepsis or septic shock (n = 298 monotherapy n 302 therapy). was performed 44 intensive care units in...
Objective The attitudes about the usage of artificial intelligence in healthcare are controversial. Unlike perception professionals, patients and their companions have been less interest so far. In this study, we aimed to investigate among highly relevant group along with influence digital affinity sociodemographic factors. Methods We conducted a cross-sectional study using paper-based questionnaire at German tertiary referral hospital from December 2019 February 2020. consisted three...
We aimed to objectify and compare persisting self-reported symptoms in initially hospitalized non-hospitalized patients after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by applying clinical standardized measures.We conducted a cross-sectional study of adult confirmed SARS-CoV-2 including medical history, neurological examination, blood markers, neuropsychological testing, patient-reported outcome measures (PROMs), brain magnetic resonance imaging (MRI).Fifty...
The influence of hydroxyethyl starch (HES) solutions on renal function is controversial. We investigated the effect HES administration in critically ill patients enrolled a large multicentre observational European study.All adult admitted to 198 participating intensive care units (ICUs) during 15-day period were enrolled. Prospectively collected data included daily fluid administration, urine output, sequential organ failure assessment (SOFA) score, serum creatinine levels, and need for...
Second-generation FloTrac software has been shown to reliably measure cardiac output (CO) in surgical patients. However, concerns have raised regarding its accuracy vasoplegic states. The aim of the present multicenter study was investigate third-generation patients with sepsis, particularly when total systemic vascular resistance (TSVR) is low.Fifty-eight septic were included this prospective observational four university-affiliated ICUs. Reference CO measured by bolus pulmonary...
Summary Introduction: This article is part of the Focus Theme Methods Information in Medicine on German Medical Informatics Initiative. “Smart Technology for Healthcare (SMITH)” one four consortia funded by Initiative (MI-I) to create an alliance universities, university hospitals, research institutions and IT companies. SMITH’s goals are establish Data Integration Centers (DICs) at each SMITH partner hospital implement use cases which demonstrate usefulness approach. Objectives: To give...
Nutrition support is a necessary therapy for critically ill cardiac surgery patients. However, conclusive evidence this population, consisting of well-conducted clinical trials lacking. To clarify optimal strategies to improve outcomes, an international multidisciplinary group 25 experts from different specialties Germany, Canada, Greece, USA and Russia discussed potential approaches identify patients who may benefit nutrition support, when best initiate the use pharmaco-nutrition modulate...
Summary This consensus‐ based S1 Guideline for perioperative infusion therapy in children is focused on safety and efficacy. The objective to maintain or re‐establish the child's normal physiological state (normovolemia, tissue perfusion, metabolic function, acid‐ base‐ electrolyte status). Therefore, fasting times should be as short possible prevent patient discomfort, dehydration, ketoacidosis. A physiologically composed balanced isotonic solution (BS) with 1–2.5% glucose recommended...
Clinical data after cardiac surgery and experimental mouse models of acute kidney injury suggest a renoprotective role macrophage migration inhibitory factor (MIF).