A5079289958- COVID-19 Clinical Research Studies
- Blood disorders and treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Cell Function and Interaction
- German legal, social, and political studies
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- Sociology and Education Studies
- European history and politics
- SARS-CoV-2 and COVID-19 Research
- Diabetes Treatment and Management
- Immunodeficiency and Autoimmune Disorders
- Populism, Right-Wing Movements
- Immune cells in cancer
- HIV Research and Treatment
- Chronic Disease Management Strategies
- Long-Term Effects of COVID-19
- Diabetes Management and Research
- Communism, Protests, Social Movements
- SARS-CoV-2 detection and testing
- Water-Energy-Food Nexus Studies
- Cell death mechanisms and regulation
- Liver Disease Diagnosis and Treatment
- Psychology, Coaching, and Therapy
- Psychoanalysis and Social Critique
University Medical Center Freiburg
2015-2024
University of Freiburg
2024
University Hospital Bonn
2016-2023
University of Bonn
2018-2023
German Center for Infection Research
2019-2023
Asklepios
2007-2014
Park-Klinik Birkenwerder
2007-2014
GESIS - Leibniz-Institute for the Social Sciences
2010
Abstract Background The SARS-CoV-2 pandemic is currently leading to increasing numbers of COVID-19 patients all over the world. Clinical presentations range from asymptomatic, mild respiratory tract infection, severe cases with acute distress syndrome, failure, and death. Reports on a dysregulated immune system in call for better characterization understanding changes system. Methods In order dissect COVID-19-driven host responses, we performed RNA-seq whole blood cell transcriptomes...
Gain-of-function (GOF) mutations in the signal transducer and activator of transcription 1 (STAT1) result unbalanced STAT signaling cause immune dysregulation immunodeficiency. The latter is often characterized by susceptibility to recurrent Candida infections, resulting clinical picture chronic mucocutaneous candidiasis (CMC). This study aims assess frequency GOF STAT1 a large international cohort CMC patients. was sequenced genomic DNA from 57 patients 35 healthy family members. functional...
Group 1 innate lymphoid cells (ILCs) comprise a heterogeneous family of cytotoxic natural killer (NK) and ILC1s. We identify population "liver-type" ILC1s with transcriptional, phenotypic, functional features distinct from those conventional liver-resident NK as well other previously described human ILC1 subsets. LT-ILC1s are CD49a+CD94+CD200R1+, express the transcription factor T-BET, do not activating receptor NKp80 or EOMES. Similar to cells, liver-type produce IFN-γ, TNF-α, GM-CSF;...
Defective FAS (CD95/Apo-1/TNFRSF6) signaling causes autoimmune lymphoproliferative syndrome (ALPS). Hypergammaglobulinemia is a common feature in ALPS with mutations (ALPS-FAS), but paradoxically, fewer conventional memory cells differentiate from FAS-expressing germinal center (GC) B cells. Resistance to FAS-induced apoptosis does not explain this phenotype. We tested the hypothesis that defective non-apoptotic may contribute impaired cell differentiation ALPS. analyzed secondary lymphoid...
Abstract ‘Severe Acute Respiratory Syndrome - Coronavirus-2’ (SARS-CoV-2) infection causes Coronavirus Disease 2019 (COVID-19), a mild to moderate respiratory tract in the majority of patients. A subset patients, however, progresses severe disease and failure with acute distress syndrome (ARDS). Severe COVID-19 has been associated increased neutrophil counts dysregulated immune responses. The mechanisms protective immunity forms pathogenesis inflammation courses remain largely unclear. Here,...
Abstract We compared the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike-specific antibodies to induce natural killer cell-mediated antibody-dependent cellular cytotoxicity (ADCC) in patients with infection and vaccinated persons. Analyzing plasma samples from 39 disease 2019 (COVID-19) 11 individuals, significant induction ADCC could be observed over a period more than 3 months both recovered individuals. Although antibody concentrations were lower patients, we...
Human innate lymphoid cells (ILCs) are critically involved in the modulation of homeostatic and inflammatory processes various tissues. However, only little is known about composition intrahepatic ILC pool its potential role chronic liver disease. Here, we performed a detailed characterization ILCs both healthy fibrotic livers.
SUMMARY The SARS-CoV-2 pandemic is currently leading to increasing numbers of COVID-19 patients all over the world. Clinical presentations range from asymptomatic, mild respiratory tract infection, severe cases with acute distress syndrome, failure, and death. Reports on a dysregulated immune system in calls for better characterization understanding changes system. Here, we profiled whole blood transcriptomes 39 10 control donors enabling data-driven stratification based molecular phenotype....
Human immunodeficiency virus (HIV) infection is associated with impaired natural killer (NK) cell activity, which only incompletely restored under antiretroviral therapy. Analyzing the bioenergetics profiles of oxygen consumption, we observed that several parameters were significantly reduced in HIV+ NK cells, indicating a mitochondrial defect. Accordingly, found CD56bright cells to display decreased membrane potential and mass. Both positively correlated interferon gamma (IFN-γ) production...
The mechanisms involved in HIV-associated natural killer (NK) cell impairment are still incompletely understood. We observed HIV infection to be associated with increased plasma levels of IFABP, a marker for gut epithelial barrier dysfunction, and LBP, microbial translocation. Both IFABP LBP concentrations were inversely correlated NK interferon-γ production, suggesting translocation modulate functions. Accordingly, we found lipopolysaccharide have an indirect inhibitory effect on cells via...