A5011005301- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Esophageal and GI Pathology
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Abdominal Surgery and Complications
- Neuroendocrine Tumor Research Advances
- Enhanced Recovery After Surgery
- Cardiac, Anesthesia and Surgical Outcomes
- Renal cell carcinoma treatment
- Liver physiology and pathology
- Abdominal vascular conditions and treatments
- Minimally Invasive Surgical Techniques
- Multiple and Secondary Primary Cancers
- Viral-associated cancers and disorders
- Colorectal Cancer Screening and Detection
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal motility and disorders
- Global Health and Surgery
- Liver Diseases and Immunity
University Hospital Bonn
2010-2025
Klinikum Braunschweig
2025
University of Bonn
2009-2023
Universitätsklinikum Tübingen
2016
University of Cologne
2010
Objectives: To assess pancreatic fistula rate and secondary endpoints after pancreatogastrostomy (PG) versus pancreatojejunostomy (PJ) for reconstruction in pancreatoduodenectomy the setting of a multicenter randomized controlled trial. Background: PJ PG are established methods pancreatoduodenectomy. Recent prospective trials suggest superiority regarding perioperative complications. Methods: A trial comparing with was conducted involving 14 German high-volume academic centers surgery. The...
Abstract Muscularis Externa Macrophages ( ME -Macs) and enteric glial cells (EGCs) are closely associated cell types in the bowel wall, important interactions thought to occur between them during intestinal inflammation. They involved developing postoperative ileus (POI), an acute, surgery-induced inflammatory disorder triggered by IL-1 receptor type I (IL1R1)-signaling. In this study, we demonstrate that IL1R1-signaling murine human EGCs induces a reactive state, named gliosis,...
Abstract Current studies pictured the enteric nervous system and macrophages as modulators of neuroimmune processes in inflamed gut. Expanding this view, we investigated impact neuron–macrophage interactions on postoperative trauma subsequent motility disturbances, i.e., ileus. In early postsurgical phase, detected strong neuronal activation, followed by transcriptional translational signatures indicating death synaptic damage. Simultaneously, our study revealed neurodegenerative profiles...
Indications for peritoneal dialysis (PD) have undergone a paradigm shift in recent years. Medical barriers previously viewed as contraindications PD such anuria, autosomal dominant polycystic kidney disease, cardiovascular diseases or advanced age are increasingly re-examined. We learned that establishing safe, functional and durable catheter access can be established even patients with variety of co-morbidities. Moreover, conditions predispose to catheter-related infections peritonitis not...
Pancreatic ductal adenocarcinomas (PDACs) are chemoresistant, resulting in extremely poor survival of patients; therefore, novel molecular targets, even small subsets genetically characterized tumours, urgently needed. Tyrosine kinase receptor inhibitors (TKIs) already clinical use. The aims this study were to examine the gene copy number and expression fibroblast growth factor 1 (FGFR1) 155 patients with PDAC, investigate effects FGFR-specific inhibitor BGJ398 on FGFR1-amplified pancreatic...
Abstract Background Abdominal surgery results in neuronal mediator release and subsequent acute intestinal hypomotility. This phase is followed by a longer lasting inflammatory resulting postoperative ileus ( POI ). Calcitonin gene‐related peptide CGRP ) has been shown to induce motility disturbances addition may be candidate elicit neurogenic inflammation. We hypothesized that contributes inflammation . Methods The effect of was tested mice treated with the highly specific receptor...
Delayed gastric emptying (DGE) remains the most frequent complication following pancreatoduodenectomy (PD) with published incidences as high 61%. The present study investigates impact of bowel reconstruction techniques on DGE classic PD (Whipple-Kausch procedure) pancreatogastrostomy (PG).We included 168 consecutive patients who underwent PG either Billroth II type (BII, n = 78) or Roux-en-Y (ReY, 90) between 2004 and 2015. Excluded were conventional single loop after pylorus preserving...
Human innate lymphoid cells (ILCs) are critically involved in the modulation of homeostatic and inflammatory processes various tissues. However, only little is known about composition intrahepatic ILC pool its potential role chronic liver disease. Here, we performed a detailed characterization ILCs both healthy fibrotic livers.
Background. Even optimal nerve reconstruction after facial damage leads to defective reinnervation because of misdirected axonal sprouting and polyinnervation the end plates muscles. Objective. The authors studied whether temporary chemical denervation contralateral nonlesioned hemiface with botulinum toxin (BTX) would increase regeneration lesioned buccal branch improve functional recovery whisker pad. Methods. experiments were performed in 65 adult rats distributed 4 interventions: (1)...
Prognosis of patients with pancreatic cancer is still extremely poor. First-line palliative therapies FOLFIRINOX or gemcitabine/nab-paclitaxel have been established in the last decade. In second-line, 5-FU/LV combination nanoliposomal irinotecan (nal-IRI) after gemcitabine has shown to be effective. However, use nal-IRI as third-line therapy and gemcitabine-based chemotherapies controversial. this study, we report about + a daily practice analyze whether an option...
Cholangiocarcinoma (CCA) still has a poor prognosis and remains major therapeutic challenge. When curative resection is not possible, palliative systemic chemotherapy with gemcitabine platinum derivate as first line followed by 5-FU doublet combination second the standard therapy. Recently, targeted therapy immunotherapy have rapidly emerged personalized approaches requiring previous tumor sequencing molecular profiling. BRCA mutations are well-characterized targets for poly (ADP-ribose)...
Pancreaticoduodenectomy is a demanding procedure even in selected patients but becomes formidable when performed cases of emergency. This study analyzed our experience with urgent pancreatoduodenectomies; special emphases were put on the evaluation diagnostic means and validation existing indications for performance this procedure.Three hundred one who underwent pancreatoduodenectomy between 1989 2008 identified from pancreatic resection database reviewed emergency indications.Six (2%)...
(1) Background: This study’s goals were to investigate possible risk factors for clinically relevant postoperative pancreatic fistula (POPF) grade B/C according the updated definitions of International Study Group Pancreatic Surgery and analyze treatment strategies; (2) Methods: Between 2017 2021, 200 patients analyzed regarding development POPF with an emphasis on outcome (3) Results: was observed in 39 (19.5%). These younger, mainly male, had fewer comorbidities showed a higher body mass...
Objective Prognosis of patients with irresectable cholangiocarcinoma is still poor. The ABC-02 trial established the current first line (1L) standard systemic chemotherapy (CT) gemcitabine/platinum derivate for advanced cholangiocarcinoma. However, majority needed therapy adaptions. Thus, aim this study was to evaluate 1L and second (2L) regimens impact adaptions in an unselected real-life cohort Materials Methods This a single institution retrospective analysis who were treated from 2010...
Background and Aim: There are several existing systemic 1st- line therapies for advanced hepatocellular carcinoma (HCC), including atezolizumab/bevacizumab (Atez/Bev), sorafenib lenvatinib. This study aims to compare the effectiveness of these three 1st-line treatments in a real-world setting HCC, focusing on specific patient subgroups analysis. Methods: A total 177 patients with HCC treated Atez/Bev (n = 38), lenvatinib 21) or 118) as 1st therapy were retrospectively analyzed compared....
Background: Pancreatic adenocarcinoma (PaC) still has a dismal prognosis, and despite medical advances, bleak 5-year survival rate of only 8%, largely due to late diagnosis limited curative surgical options for most patients. Frontline palliative treatment shows some advantages. However, the high disease mortality is accompanied by morbidity including cancer-related pain additional symptoms, which strongly impair patients’ quality life (QOL). At present, there no established strategy local...
Abstract The early and definitive diagnosis of malignant bile duct stenoses is essential for a timely adequate therapy. However, tissue sampling with transpapillary brush cytology (BC) or forceps biopsy (FB) remains challenging. With this study, we aimed to compare the effectiveness safety different modalities (BC, FB without/after previous balloon dilatation). Standardized database research identified all patients, who underwent endoscopic retrograde cholangiography BC and/or indeterminate...