A5087116192- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Appendicitis Diagnosis and Management
- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Receptor Mechanisms and Signaling
- Nicotinic Acetylcholine Receptors Study
- Anorectal Disease Treatments and Outcomes
- Abdominal Trauma and Injuries
- Intraperitoneal and Appendiceal Malignancies
- Pancreatitis Pathology and Treatment
- Tracheal and airway disorders
- Esophageal and GI Pathology
- Viral Infections and Immunology Research
- Immune Cell Function and Interaction
- Cardiac, Anesthesia and Surgical Outcomes
- Neuroendocrine Tumor Research Advances
- Pelvic floor disorders treatments
- Vagus Nerve Stimulation Research
- Abdominal Surgery and Complications
- Cytomegalovirus and herpesvirus research
- Pancreatic and Hepatic Oncology Research
- T-cell and B-cell Immunology
- Trauma Management and Diagnosis
Justus-Liebig-Universität Gießen
2015-2024
Universitätsklinikum Gießen und Marburg
2015-2024
Giessen School of Theology
2005-2024
Cardio-Pulmonary Institute
2022-2023
German Center for Lung Research
2014-2022
Universities of Giessen and Marburg Lung Center
2007-2020
Else Kröner-Fresenius-Stiftung
2016
University Medical Center Hamburg-Eppendorf
2016
Hammersmith Hospital
2016
University of Cologne
2016
To evaluate a new 2-step technique for obtaining adequate but short-term parenchymal hypertrophy in oncologic patients requiring extended right hepatic resection with limited functional reserve.Patients presenting primary or metastatic liver tumors often face the dilemma that remaining tissue may not be sufficient. Preoperative portal vein embolization has thus far been established as standard procedure achieving resectability.Two-staged hepatectomy was performed who preoperatively appeared...
Objectives: To assess pancreatic fistula rate and secondary endpoints after pancreatogastrostomy (PG) versus pancreatojejunostomy (PJ) for reconstruction in pancreatoduodenectomy the setting of a multicenter randomized controlled trial. Background: PJ PG are established methods pancreatoduodenectomy. Recent prospective trials suggest superiority regarding perioperative complications. Methods: A trial comparing with was conducted involving 14 German high-volume academic centers surgery. The...
Historical data indicate that surgical resection may benefit select patients with metastatic gastric and gastroesophageal junction cancer. However, randomized clinical trials are lacking. The current RENAISSANCE trial addresses the potential benefits of intervention in cancer limited metastases. This is a prospective, multicenter, randomized, investigator-initiated phase III trial. Previously untreated stage (retroperitoneal lymph node metastases only or maximum one incurable organ site...
Abstract Background The SARS-CoV-2 pandemic is a major challenge for health care services worldwide. It’s impact on oncologic therapies and elective surgery has been described recently, the literature provides guidelines regarding appropriate patient treatment during pandemic. However, of emergency poorly investigated up to now. Methods A 17-item web survey had distributed surgeons in June 2020 around world, investigating patients septic diseases both requiring time-to-intervention routine,...
Abstract IL-1β is a potent proinflammatory cytokine of the innate immune system that involved in host defense against infection. However, increased production plays pathogenic role various inflammatory diseases, such as rheumatoid arthritis, gout, sepsis, stroke, and transplant rejection. To prevent detrimental collateral damage, release tightly controlled typically requires two consecutive danger signals. LPS from Gram-negative bacteria prototypical first signal inducing pro–IL-1β...
Abstract We demonstrated previously that phosphocholine and phosphocholine-modified macromolecules efficiently inhibit ATP-dependent release of interleukin-1β from human murine monocytes by a mechanism involving nicotinic acetylcholine receptors (nAChR). Interleukin-1β is potent pro-inflammatory cytokine innate immunity plays pivotal roles in host defence. Control vital as excessively high systemic levels cause life threatening inflammatory diseases. In spite its structural similarity to...
PURPOSE: This study was designed to analyze the efficacy of Surgisis® Anal Fistula Plug™ for closure transsphincteric anorectal fistulas. METHODS: Patients with single fistulas were prospectively enrolled. Setons used in all tracts at least eight weeks before surgery. Continence, surgical variables, complications, and healing rates recorded. Surgery performed a standardized manner. The fistula tract external opening debrided, irrigated, plug placed. left open. Success defined as absence...
Recently, we discovered a cholinergic mechanism that inhibits the ATP-dependent release of interleukin-1β (IL-1β) by human monocytes via nicotinic acetylcholine receptors (nAChRs) composed α7, α9 and/or α10 subunits. Furthermore, identified phosphocholine and dipalmitoylphosphatidylcholine as novel agonists elicit metabotropic activity at monocytic nAChR. Interestingly, does not provoke ion channel responses conventional nAChRs subunits α10. The purpose this study is to determine composition...
Immunological monitoring for chronic allograft nephropathy (CAN) is of great potential interest. We assessed serum soluble CD30 (sCD30) together with in vitro Th2-type responses (IL-4, IL-10, CD4 helper activity) and neopterin a prospective study 84 renal transplant recipients 2-year follow-up. Patients were randomized to CsA/Aza, CsA/MMF Tacr/Aza, respectively, analyze the effect immunosuppression on posttransplant sCD30 neopterin. ATG induction acute rejections did not alter levels whereas...
To determine the effect of peridural analgesia on long-term survival in patients who underwent surgical treatment colorectal carcinoma.Clinical and animal studies suggest a potential benefit morbidity mortality after cancer surgery. The outcome surgery for remains undefined.From 2003 to 2009, there were 749 carcinoma under general anesthesia with or without analgesia. Clinical data reviewed retrospectively analyzed multivariate analysis Kaplan-Meier plots.There 442 received 307 did not...
Blood levels of the acute phase reactant C-reactive protein (CRP) are frequently measured as a clinical marker for inflammation, but biological functions CRP still controversial. is phosphocholine (PC)-binding pentraxin, mainly produced in liver response to elevated interleukin-1β (IL-1β) and IL-1β-dependent cytokine IL-6. While both cytokines play important roles host defense, excessive systemic IL-1β can cause life-threatening diseases such trauma-associated inflammation. We hypothesized...
Delayed gastric emptying (DGE) is one of the most common complications after pancreatic head resection. It leads to increased length hospital stay, high costs for healthcare systems and reduced quality life. The primary aim study was assess impact pylorus preservation, respectively resection on occurrence DGE in patients undergoing pancreaticoduodenectomy (PD).All cases pylorus-resecting PD (PRPD) pylorus-preserving (PPPD) entered StuDoQ|Pancreas nationwide registry German Society General...
The SARS-CoV-2 pandemic is still ongoing and a major challenge for health care services worldwide. In the first WSES COVID-19 emergency surgery survey, strong negative impact on (ES) had been described already early in situation. However, knowledge limited about current effects of patient flow through rooms, daily routine decision making ES as well their changes over time during last two years. This second survey investigates course pandemic.A web distributed to medical specialists four-week...
Abstract A new role and source of the old mediator acetylcholine is described, which produced by graft monocytes attenuates monocytic ATP-signaling. During acute rejection, large numbers leukocytes accumulate in blood vessels experimental renal allografts. About 70% them are activated, cytotoxic that appear to be involved allograft destruction. ACh exerts anti-inflammatory effects upon monocytes/macrophages has been proposed a key player neuroimmunological interactions. Its short half-life,...