D Pantalone
A5015149840- Appendicitis Diagnosis and Management
- Pancreatic and Hepatic Oncology Research
- Cardiac, Anesthesia and Surgical Outcomes
- Abdominal Surgery and Complications
- Spaceflight effects on biology
- Colorectal Cancer Treatments and Studies
- Diverticular Disease and Complications
- COVID-19 and healthcare impacts
- Gastric Cancer Management and Outcomes
- Diet and metabolism studies
- Gastrointestinal motility and disorders
- Gallbladder and Bile Duct Disorders
- Space Exploration and Technology
- Esophageal and GI Pathology
- Trauma and Emergency Care Studies
- Cancer Treatment and Pharmacology
- Colorectal Cancer Surgical Treatments
- Gastroesophageal reflux and treatments
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Medical Malpractice and Liability Issues
- Cardiovascular and Diving-Related Complications
- Wound Healing and Treatments
- Pancreatitis Pathology and Treatment
- Biliary and Gastrointestinal Fistulas
Fluor (United States)
2024
Collaborative Group (United States)
2024
University of Florence
2000-2023
Azienda Ospedaliero-Universitaria Careggi
2020-2023
American College of Surgeons
2023
European Space Agency
2021
Vårdcentralen Teleborg
2020
Satra (United Kingdom)
2020
Karolinska Institutet
2020
Abstract Background Severe complicated intra-abdominal sepsis (SCIAS) has an increasing incidence with mortality rates over 80% in some settings. Mortality typically results from disruption of the gastrointestinal tract, progressive and self-perpetuating bio-mediator generation, systemic inflammation, multiple organ failure. A further therapeutic option may be open abdomen (OA) management negative peritoneal pressure therapy (NPPT) to remove inflammatory ascites attenuate damage SCIAS,...
The plane between longitudinal and circular muscle of human colon, as revealed on examination with light electron microscopes, has no clear-cut border. Some groups smooth cells, obliquely oriented features similar to both ones – the connecting bundles run from one layer another. Other possessing their own specific ultrastructural myenteric sheaths - make up envelopes variable thickness around some ganglia nerve strands, partially or completely embedding them in other layer. Non-neuronal,...
Colonic motility study was performed on a total of 145 patients. Of these, 55 were patients with symptomatic complicated diverticular disease, 30 had uncomplicated asymptomatic and controls. The pressure sensors positioned in the descending true sigmoid colon. index significantly higher rather than disease resting (P< 0.001) postprandial states. This confirmed association between high intraluminal pressure. subgroup—complicated disease—were relatively young (mean age: 51.1±2.02 years) short...
Wound healing is a very complex process that allows organisms to survive injuries. It strictly regulated by number of biochemical and physical factors, mechanical forces included. Studying wound in space interesting for two main reasons: (i) defining tools, procedures, protocols manage serious wounds burns eventually occurring future long-lasting exploration missions, without the possibility timely medical evacuation Earth; (ii) understanding role gravity factors scarring, thus contributing...
The SARS-CoV-2 pandemic is still ongoing and a major challenge for health care services worldwide. In the first WSES COVID-19 emergency surgery survey, strong negative impact on (ES) had been described already early in situation. However, knowledge limited about current effects of patient flow through rooms, daily routine decision making ES as well their changes over time during last two years. This second survey investigates course pandemic.A web distributed to medical specialists four-week...
Decision-making in emergency settings is inherently complex, requiring surgeons to rapidly evaluate various clinical, diagnostic, and environmental factors. The primary objective assess a patient's risk for adverse outcomes while balancing diagnoses, management strategies, available resources. Recently, indocyanine green (ICG) fluorescence imaging has emerged as valuable tool enhance surgical vision, demonstrating proven benefits elective surgeries. This consensus paper provides...
The circular muscle layer of the human caecum and ascending colon is clearly subdivided into two portions: an outer one which includes bulk layer, inner made up only six to eight rows cells. In right transverse no demarcation can be observed, but a difference exists between innermost outermost cells, since those possess some peculiarities with regard sarcoplasmic reticulum, glycogen particles, caveolae, intercellular junctions. left part colon, also divided portions. fact, smooth cells still...
To prepare the ESA (European Space Agency) spaceflight project “Wound healing and Sutures in Unloading Conditions”, we studied mechanisms of apoptosis wound models based on ex vivo skin tissue cultures, kept for 10 days alive serum-free DMEM/F12 medium supplemented with bovine serum albumin, hydrocortisone, insulin, ascorbic acid antibiotics at 32 °C. The overall goal is to test: (i) viability specimens; (ii) gene expression activators inhibitors extracellular matrix components suture...
The COVID-19 epidemic became a challenge for Emergency Departments (ED) and remarkable reduction in surgical emergencies has been widely noticed. aim of the present study was to evaluate impact pandemic period need emergencies.Between January 1, May 31, 2020 all consecutive general surgery performed by Unit Hospital Surgery Careggi University (Florence, Italy) were prospectively recorded compared same 2019. Demographic clinical data analyzed.The number procedures decreased only month March...
The current role of chemotherapy in pancreatic carcinoma is limited, and progress the treatment this disease represents a significant challenge to medical oncology. most promising drug under study gemcitabine, relatively new antimetabolite that an attractive candidate for combination because its excellent side-effect profile absence overlapping toxicities with other chemotherapeutic agents. Combined administration gemcitabine anthracyclines could result induction DNA breaks are not easily...
A new derivative of carboxymethylcellulose was synthesised by converting some the carboxylic groups into amidic moieties (CMCA). The synthetic procedure allowed for a good control degree substitution. polysaccharide characterised in terms physico-chemical properties and biocompatibility. It also used realisation hydrogel, its behaviour, such as water uptake rheological parameters, were evaluated. CMCA hydrogel showed closer to those Hyaluronan (Hyal) rather than native (CMC). Hydrogel...
For advanced colorectal carcinoma, two new drugs, raltitrexed (TOM) and oxaliplatin (L-OHP), have recently shown interesting results. Preclinical clinical studies suggest that this combination, because of its favorable toxicity profile, high response rate convenient schedule administration, can be administered successfully in disease. In our phase II study, 37 non pre-treated patients with metastatic carcinoma were treated TOM (3 mg/m2) L-OHP (130 every 3 weeks. total, 222 cycles...
Although the incidence of pancreatic cancer is relatively low compared with other tumors (2.4%), death rate high. Tumor detection and treatment at an early stage necessary to improve poor prognosis patients, as demonstrated by some reports showing a 5-year survival varying between 19 41% for patients undergoing radical pancreatectomy highest in small tumors.In our study we retrospectively reviewed histologic demographic data 596 who were admitted surgical units Careggi Hospital (University...
Single-agent gemcitabine has been established as standard treatment for advanced pancreatic cancer since clinical studies have shown an improvement in overall survival and significant benefit when compared to the best supportive care despite low objective response. Several phase II tested other single agents different gemcitabine-based regimens cancer, but both response rates remained low. Irinotecan, a topoisomerase I inhibitor currently approved of metastatic colon also demonstrated...