A5022582588- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Hippo pathway signaling and YAP/TAZ
- PI3K/AKT/mTOR signaling in cancer
- Cancer Mechanisms and Therapy
- Sarcoma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Pancreatic function and diabetes
- Gastrointestinal Tumor Research and Treatment
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Renal cell carcinoma treatment
- Ubiquitin and proteasome pathways
- Metabolism, Diabetes, and Cancer
- Bladder and Urothelial Cancer Treatments
- Liver physiology and pathology
- Pediatric Hepatobiliary Diseases and Treatments
- Peroxisome Proliferator-Activated Receptors
- Cancer-related Molecular Pathways
- RNA modifications and cancer
University of Regensburg
2016-2025
Heidelberg University
2025
University Hospital Heidelberg
2025
University Hospital Regensburg
2015-2024
München Klinik
2024
RWTH Aachen University
2022
Universität Greifswald
2009-2021
Taipei Institute of Pathology
2005-2021
Guizhou University
2019
Guizhou Provincial People's Hospital
2019
Intrahepatic cholangiocarcinomas (ICCs) are primary liver tumors with a poor prognosis. The development of effective therapies has been hampered by limited understanding the biology ICCs. Although ICCs exhibit heterogeneity in location, histology, and marker expression, they currently thought to derive invariably from cells lining bile ducts, biliary epithelial (BECs), or progenitor (LPCs). Despite lack experimental evidence establishing BECs LPCs as origin ICCs, other cell types have not...
<h3>Objective</h3> Pancreatic cancer is characterised by invasive tumour spread and early metastasis formation. During epithelial–mesenchymal transition, loss of the cell adhesion molecule E-cadherin frequent can be caused genetic or epigenetic modifications, recruitment transcriptional activators/repressors post-translational modifications. A study was undertaken to investigate how expression in human pancreatic adenocarcinoma lines regulated. <h3>Methods</h3> In 25 resection specimens,...
The rate of microscopic incomplete resections gastrointestinal cancers including pancreatic cancer has not changed considerably over the past years. Future intra-operative applications tissue tolerable plasmas (TTP) could help to address this problem. Plasma is generated by feeding energy, like electrical discharges, gases. development non-thermal atmospheric displaying spectra temperature within or just above physiological ranges allows biological medical plasmas. We have investigated...
Objective Increased de novo fatty acid (FA) synthesis and cholesterol biosynthesis have been independently described in many tumour types, including hepatocellular carcinoma (HCC). Design We investigated the functional contribution of synthase (Fasn)-mediated FA a murine HCC model induced by loss Pten overexpression c-Met (sgPten/c-Met) using liver-specific Fasn knockout mice. Expression arrays lipidomic analysis were performed to characterise global gene expression lipid profiles,...
Activation of v-akt murine thymoma viral oncogene homolog (AKT) and Ras pathways is often implicated in carcinogenesis. However, the oncogenic cooperation between these two cascades relationship to hepatocellular carcinoma (HCC) development remains undetermined. To investigate this issue, we generated a mouse model characterized by combined overexpression activated forms AKT neuroblastoma (N-Ras) protooncogenes liver way hydrodynamic gene transfer. The molecular mechanisms underlying...
Purpose To investigate the effect of multipeak spectral modeling fat on R2* values as measures liver iron and quantification fraction, with biopsy reference standard. Materials Methods Institutional review board approval informed consent were obtained. Patients disease (n = 95; 50 men, 45 women; mean age, 57.2 years ± 14.1 [standard deviation]) underwent a nontargeted biopsy, 97 samples reviewed for steatosis grades. MR imaging at 1.5 T was performed 24–72 hours after by using three-echo...
We have shown that thymoquinone (TQ) is a potent antitumor agent in human colorectal cancer cells. In this study, we evaluated TQ's therapeutic potential two different mice colon models [1,2-dimethyl hydrazine (DMH) and xenografts]. also examined TQ effects on the growth of C26 mouse carcinoma spheroids assessed tumor invasion vitro. Mice were treated with saline, TQ, DMH, or combinations once per week for 30 weeks multiplicity, size distribution aberrant crypt foci (ACF) tumors determined...
Polo-like kinase (PLK) proteins play critical roles in the control of cell cycle progression, either favoring or inhibiting proliferation, and DNA damage response. Although overexpression down-regulation PLK occurs frequently various cancer types, no comprehensive analysis on their function human hepatocellular carcinoma (HCC) has been performed to date. In present study, we define for PLK1, PLK2, PLK3, PLK4 during hepatocarcinogenesis. Levels as assessed by means real-time...
Abstract Activation of the AKT/mTOR cascade and overexpression c-Met have been implicated in development human hepatocellular carcinoma (HCC). To elucidate functional crosstalk between two pathways, we generated a model characterized by combined expression activated AKT mouse liver. Co-expression triggered rapid liver tumor mice required to be euthanized within 8 weeks after hydrodynamic injection. At molecular level, tumors induced AKT/c-Met display activation Ras/MAPK cascades as well...
•A novel mouse model of intrahepatic cholangiocarcinoma (ICC) was established.•Hydrodynamic transfection activated forms AKT and Yap used to induce ICC.•This recapitulates many morphological molecular features human ICC.•MLN0128 may be superior gemcitabine/oxaliplatin based chemotherapy treat ICC.•The efficacy MLN0128 is mainly attributed induction apoptosis ICC cells. Background & AimsIntrahepatic a lethal malignancy without effective treatment options. MLN0128, second generation pan-mTOR...
Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most prevalent types of primary liver cancer. These malignancies have limited treatment options, resulting in poor patient outcomes. Metabolism reprogramming, including increased de novo lipogenesis, is one hallmarks Fatty acid synthase (FASN) catalyzes synthesis long‐chain fatty acids from acetyl‐coenzyme A malonyl‐coenzyme A. Increased FASN expression has been reported multiple tumor types, inhibition shown to...
Objective Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer with limited treatment options. Cabozantinib, an orally bioavailable multikinase inhibitor now approved by Food and Drug Administration (FDA) for HCC patients. We evaluated therapeutic efficacy cabozantinib, either alone or in combination, vitro vivo. Design Human cell lines mouse models were used to assess targeted molecular pathways combination pan-mTOR MLN0128 checkpoint anti-PD-L1 antibody. Results...
Hepatocellular carcinoma (HCC) is a deadly form of liver cancer with limited treatment options. The c‐Myc transcription factor pivotal player in hepatocarcinogenesis, but the mechanisms underlying oncogenic activity remain poorly delineated. Mammalian target rapamycin complex 2 (mTORC2) has been implicated by regulating multiple AGC kinases, especially AKT proteins. In liver, AKT1 and AKT2 are widely expressed. While major isoform downstream activated phosphoinositide 3‐kinase loss...