A5062840138- Renal cell carcinoma treatment
- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- Renal and related cancers
- Bladder and Urothelial Cancer Treatments
- Breast Lesions and Carcinomas
- Urinary and Genital Oncology Studies
- Photodynamic Therapy Research Studies
- Prostate Cancer Treatment and Research
- HER2/EGFR in Cancer Research
- Radiomics and Machine Learning in Medical Imaging
- PI3K/AKT/mTOR signaling in cancer
- MRI in cancer diagnosis
- Estrogen and related hormone effects
- Epigenetics and DNA Methylation
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer and Skin Lesions
- Cell Adhesion Molecules Research
- COVID-19 and healthcare impacts
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Nanoplatforms for cancer theranostics
- Hormonal and reproductive studies
- Cancer Cells and Metastasis
- Colorectal Cancer Surgical Treatments
- Cancer-related Molecular Pathways
University College London
2010-2025
Royal Free London NHS Foundation Trust
2015-2025
The Royal Free Hospital
2008-2024
Royal London Hospital
2024
University of Edinburgh
2024
London Cancer
2022-2023
Cancer Institute (WIA)
2022
Leeds Teaching Hospitals NHS Trust
2021
University of Wales
2021
Cardiff University
2021
In April 2012, an outbreak of acute respiratory illness occurred in a public hospital Zarqa city, Jordan; 8 health care workers were among the 11 people affected, 1 who later died. The cause was unknown at time and epidemiological investigation including laboratory testing carried out immediately afterthe inconclusive. Following discovery novel coronavirus infection (nCoV) Arabian peninsula September stored serum samples patients from this retested diagnosis nCoV confirmed 2 deceased...
Caveolin-1 (CAV1) and caveolin 2 (CAV2) are the principal structural proteins of caveolae, sphingolipid cholesterol-rich invaginations plasma membrane involved in vesicular trafficking signal transduction. Over recent years there has been controversy about their role breast cancer suitability as markers basal-like phenotype. CAV2 protein expression was assessed on a tissue microarray containing 880 unselected invasive cases, by means immunohistochemistry. observed 13.4 5.9% all cancer,...
Photodynamic therapy (PDT) is a technique for producing localized necrosis with light after prior administration of photosensitizing agent. This study investigates the nature, safety, and efficacy PDT image-guided treatment primary breast cancer. We performed phase I/IIa dose escalation in 12 female patients new diagnosis invasive ductal cancer scheduled to undergo mastectomy as first treatment. The photosensitizer verteporfin (0.4 mg/kg) was administered intravenously followed by exposure...
BackgroundRecent clinical evidence showed that breast cancer with low HER2 expression levels responded to trastuzumab deruxtecan therapy. The HER2-low cancers comprise immunohistochemistry (IHC) score 1+ and 2+ ISH non-amplified tumours, currently classified as negative. Little data exists on the reproducibility of pathologists reporting cancer.Patient methodsSixteen expert UK National Coordinating Committee for Breast Pathology scored 50 digitally scanned IHC slides. overall level...
Multiparameter analysis of core regulatory proteins involved in G1–S and G2–M cell-cycle transitions provides a powerful biomarker readout for assessment the state. We have applied this algorithm to breast cancer investigate how cell cycle impacts on disease progression. Protein expression profiles key constituents DNA replication licensing pathway (Mcm2, geminin) mitotic machinery (Plk1, Aurora A substrate histone H3S10ph) were generated cohort 182 patients linked clinicopathological...
Ta grade 3 (G3) non–muscle-invasive bladder cancer (NMIBC) is a relatively rare diagnosis with an ambiguous character owing to the presence of aggressive G3 component together lower malignant potential component. The European Association Urology (EAU) NMIBC guidelines recently changed risk stratification for from high intermediate, high, or very risk. However, prognostic studies on carcinomas are limited and inconclusive. To evaluate value categorizing compared G2 T1 carcinomas. Individual...
Background: Locally advanced breast cancer (LABC) is still a common presentation in Sudan. Lack of awareness guidelines lead to high rates unnecessary mastectomies among patients with locally cancer. Objective: To compare the outcome conservative surgery and modified radical mastectomy after neoadjuvant therapy for Patients Methods: Descriptive, cross-sectional, hospital-based study. Included all seen National Cancer Institute-University Gezira from period December 2018 February 2020 who...
Background: The diagnosis of upper urinary tract urothelial carcinoma (UTUC) in cytological specimens is challenging, particularly the designation atypical cells (AUC). application Paris System for Reporting Urinary Cytology (TPS) has improved performance lower but shown variable results specimens, which are frequently instrumented. Methods: This retrospective study analysed selective cytology samples from January to December 2023. Samples were classified under TPS 2.0 categories....
This study evaluates the usability and workload associated with pneumatically attachable flexible (PAF) rail, a soft robotic device designed for safer organ manipulation retraction during robotic-assisted partial nephrectomy (RAPN) other laparoscopic procedures. Fourteen expert surgeons performed simulated surgical task using PAF rail standard instruments. Usability was assessed System Scale (SUS), measured NASA-TLX. Qualitative feedback also collected to explore surgeon perceptions,...
Despite multiple reports of overexpression in prostate cancer (PC), the reliance PC cells on activated epidermal growth factor receptor (EGFR) and its downstream signaling to phosphoinositide 3'-kinase/Akt (PI3K/Akt/PTEN) and/or mitogen-activated protein kinase (MAPK/ERK) pathways has not been fully elucidated. In this study, we compared role EGF-mediated nonmalignant (BPH-1, PNT1A, PNT1 B) cell lines (DU145, PC3, LNCaP, CWR22Rv1). EGF-induced proliferation was observed all EGFR-expressing...
Intratumoral genetic heterogeneity and the role of metabolic reprogramming in renal cell carcinoma have been extensively documented. However, distribution these changes within tissue has not explored. We report on first-in-human vivo non-invasive interrogation using hyperpolarized carbon-13 ( 13 C) MRI describe validation lactate against multi regional ex mass spectrometry. C)-MRI provides an assessment metabolism a novel opportunity to safely non-invasively assess cancer heterogeneity.
Introduction Triple negative breast cancer (TNBC) is a subtype of characterised by its high tumourigenic, invasive, and immunosuppressive nature. Photodynamic therapy (PDT) focal that uses light to activate photosensitizing agent induce cytotoxic effect. 5-aza-2’-deoxycytidine (5-ADC) clinically approved immunomodulatory chemotherapy agent. The mechanism the combination using PDT 5-ADC in evoking an anti-tumour response not fully understood. Methods present study examined whether single dose...
One limitation of current biochemical or histologic analysis advanced prostate cancer (PC; T3/T4 ±Nx Mx) is the ability to identify on first diagnostic biopsy patients who will make a durable response hormone ablation therapy. The aim this study was assess predictive value (sustained hormonal therapy and clinical outcome (relapse-free overall survival)) phosphatase tensin homolog (PTEN) androgen receptor (AR) immunoexpression in presenting biopsy. Analysis performed 47 samples (10 cases...
To study the natural history of renal oncocytomas and address indications for intervention by determining how growth is associated with function over time, reasons surgery ablation, disease-specific survival.The was conducted in a retrospective cohort consecutive patients oncocytoma on active surveillance reviewed at Specialist Centre Kidney Cancer Royal Free London NHS Foundation Trust (2012 to 2019). Comparison between groups performed using Mann-Whitney U-tests chi-squared tests. A...
One step nucleic acid (OSNA) is a molecular diagnostic assay for intra-operative detection of sentinel node metastases. This study compared OSNA with standard histopathology in 283 nodes from 170 patients to evaluate sensitivity, specificity and concordance the two methods. Additional analysis was done investigate how cytokeratin 19 mRNA copy number affects prediction non-sentinel positivity. sensitivity 93.2% 95.8%. Concordance between histology 95.6%. In who had axillary clearance, on 100%...
The incidence of renal tumours is increasing and anatomic imaging cannot reliably distinguish benign from cell carcinoma. Up to 30% are benign, with oncocytomas the most common type. Biopsy has not been routinely adopted in many centres due concerns surrounding non-diagnostic rate, bleeding tumour seeding. As a result, masses often unnecessarily surgically resected. 99mTc-sestamibi SPECT/CT shown high diagnostic accuracy for other oncocytic neoplasms low malignant potential single-centre...
To analyse and compare the expression of cyclooxygenase (COX) enzymes in schistosoma-associated bladder cancer, to determine any association with tumour grade or stage.Sixty paired samples adjacent nonmalignant urothelium were identified. There 25 squamous 28 transitional cell carcinomas, seven adenocarcinomas. Serial sections obtained a standard three-layer immunohistochemistry protocol, using COX-1- COX-2-specific mouse monoclonal antibodies, applied.COX-1 was expressed mostly nonvascular...
Recent advancements in 3D vitro culture have allowed for the development of cancer tissue models which accurately recapitulate tumour microenvironment. Consequently, there has been increased innovation therapeutic drug screening. While organoid cultures show great potential, they are limited by time scale their growth and dependence upon commercial matrices, such as Matrigel, do not allow manipulations composition or mechanical properties. Here, we a straightforward approach isolation...