Caveolin-1 (CAV1) and caveolin 2 (CAV2) are the principal structural proteins of caveolae, sphingolipid cholesterol-rich invaginations plasma membrane involved in vesicular trafficking signal transduction. Over recent years there has been controversy about their role breast cancer suitability as markers basal-like phenotype. CAV2 protein expression was assessed on a tissue microarray containing 880 unselected invasive cases, by means immunohistochemistry. observed 13.4 5.9% all cancer,...

Slowing down age-related neurocognitive impairment has been a challenge. We evaluated the therapeutic effects of metformin in D-galactose-induced aging. Additionally, we studied potential molecular mechanisms that could be responsible for metformin's anti-aging effects. Thirty male rats were equally divided into: 1-control group, which received saline solution, 2-D-galactose (D-gal) D-galactose (100 mg/kg/day) by gastric lavage eight weeks, and 3-D-galactose + Metformin (D-gal Met) treated...

Acetaminophen (APAP)-induced toxicity is a predominant cause of acute hepatic and renal failure. In both humans rodents begins with reactive metabolite that binds to proteins. This leads mitochondrial dysfunction nuclear DNA fragmentation resulting in necrotic cell death. Pleurotus ostreatus (an edible oyster mushroom) well recognized as flavourful food, medicinal supplement. the present study, we evaluated role protection against APAP-induced hepato-renal toxicity. We also explored...

Background: Lipoid proteinosis (Urbach-Wiethe disease) is a rare progressive autosomal recessive disorder, characterized histologically by deposition of periodic acid Schiff-positive, diastase resistant, hyaline-like material into the skin, upper aerodigestive tract, and internal organs. Main observation:We report two cases lipoid proteinosis.A 2-year-old girl presented with vesiculobullous skin lesions on her face, trunk, extremities scalp, inability to protrude tongue hoarseness voice that...

Neocryptolepine (5-methyl-5H-indolo[2,3-b] quinoline) analogs were synthesized and evaluated in vitro vivo for their effect versus Ehrlich ascites carcinoma (EAC). The showed stronger cytotoxic activity against EAC cells than the reference drug. evaluation of target compounds EAC-induced solid tumor female albino Swiss mice revealed a remarkable decrease volume (TV) hepatic lipid peroxidation. A noticeable increase both superoxide dismutase (SOD) catalase (CAT) levels was reported (p <...

Nuclear factor kappa B (NFκB) is a key regulatory element in variety of immune and inflammatory pathways, cellular proliferation, differentiation apoptosis. Cyclo-oxygenase 2 (COX2) one the downstream targets NFκB. The current work aimed to explore possible role NFκB COX2 psoriasis pathogenesis through their immunohistochemical (IHC) expression skin biopsies this disease correlating with clinico-pathological parameters studied cases. 103 subjects were studied; including 58 cases vulgaris...

Background: Kaposi sarcoma (KS) is a neoplasm of the endothelial cells.It often manifests with multiple vascular nodules on skin and other organs.It systemic, malignant multifactorial disease has variable course.There are four types: classic, endemic, iatrogenic HIV-associated.The primary presentation penis face uncommon mainly observed in HIV-positive patients.Multiple treatment modalities used including surgery, cryotherapy, electrosurgery, laser radiation therapy.Main observation: The...

Not only is diabetic nephropathy (DN) the most common cause of end-stage renal disease worldwide, but it also increases risk mortality up to fourteen times compared normoalbuminuric patients.The aim current study was evaluation renoprotective effects vitamin D in DN and possible interplay between autophagy mTOR pathways.Fifty male Wistar albino rats were divided (10/group) into control, group, insulin-treated D-treated combined insulin group. Assessments systolic blood pressure, albuminuria,...

Pleomorphic adenoma (PA) of the breast is a rare tumour seen usually in postmenopausal women. Although PA salivary glands (SG) recognized to be benign tumour, nature and biology similar tumours remains defined. The aim this study was describe that reported on core biopsy as an invasive matrix-producing metaplastic carcinoma (MBC).A from clinically malignant retroareolar mass showed mildly atypical polygonal cells with surrounding myxoid stroma. Immunohistochemistry expression basal luminal...

John Cunningham virus (JCV) encodes an oncogenic T-antigen, which is capable of interacting with key growth regulatory pathways. JCV definite role as causal agent human cancer, still awaits final confirmation. The present study was conducted to assess the possible in Egyptian colorectal carcinoma (CRC) and correlate expression clinicopathological features survival. situ hybridization (ISH) signals large T antigen immunoreactivity were examined 87 colonic specimens. Positive glandular ISH...

Abstract Background The prevalence of hypertension and obesity has increased significantly in recent decades. Hypertension often coexist, both are associated with cardiovascular mortality. Obese hypertensive patients usually require special anti-hypertensive treatment strategy due to the risk resistance. Molecules that can target underlying pathologies should get more attention. Herein, we evaluated therapeutic effects telmisartan, interest visceral adipose tissue dysfunction,...

Backgrounds Diagnosis of allergic fungal rhinosinusitis (AFRS) is complicated because the presence fungi on mucosal surfaces sinonasal passages. The objectives this study were to define, using immunohistochemistry, lymphocyte populations associated with noninvasive fungal-related chronic (CRS; AFRS and FBs [FB]) relative CRS nasal polyposis (CRSwNP) without (CRSsNP) as a means diagnosing different forms CRS. Methods Sinus CT scans, endoscopy scores, eosinophilic mucin or used prospectively...

Trichoepithelioma (TE) is a benign tumor of follicular origin that presents as small, skin-colored papules predominantly on the face. When more than one family member affected, disease known multiple familial trichoepithelioma (MFT). It rare autosomal dominant (AD) skin disease. Malignant transformation very rare. We present case MFT in female patient and her father with malignant to basal cell carcinoma (BCC) father. summarized main histological differential parameters between TE BCC...

Histiocytoses are a heterogeneous group of disorders characterized by proliferation and accumulation cells mononuclear-macrophage system dendritic cells. categorized according to the cell origin into Langerhans histiocytosis (LCH), Non histiocytoses indeterminate (ICH). ICH is an extraordinary rare neoplastic disorder that has poorly understood histogenesis pathogenesis. It cells, which mimic immunophenotypically (positive for CD1a S-100 protein), but lack Birbeck granules characteristic...

Leptin has been recognized as an important factor for promoting normal cutaneous wound healing. The aim of this work was to explore leptin expression in keloid and hypertrophic scars (HS) compared with surgical skin. relationship clinicopathologic parameters studied cases also evaluated. Using immunohistochemical techniques, analyzed skin biopsies 60 nonobese subjects without metabolic syndrome who presented keloids (20), HS (20). Twenty samples, from age-matched, sex-matched, body mass...

Vitiligo is an acquired autoimmune skin disorder. The often-visible lesions of vitiligo have a major impact on patients' quality life and the results treatment regimens offer are unsatisfactory, so there need for new therapeutic regimens. Recent advances in pathogenesis led to recognition importance JAK-STAT pathway as attractive option.To evaluate role JAK1 STAT3 vitiligo.This prospective case-control study was carried out 35 patients presenting with 20 apparently healthy age- sex-matched...

Pityriasis rotunda is a rare disorder of keratinization characterized by hyper-or hypopigmented, geometrically perfect circular sharply defined patches dry ichthyosiform scaling. 1 The condition was initially described in Japan Toyama 1906. 2 It as pityriasis circinata and acquired pseudoichthyosis. A 19-year-old male presented persistent, large, scaling with no inflammatory changes one year duration.There history itching or oozing from the lesions.There suggestive systemic illness drug...