Hypoxia Inducible Factor-1 (HIF-1) is a mediator enabling cell adaptation to hypoxia. It plays its role mainly through transcription of many target genes including Glucose Transporter-1 (GLUT-1) gene.The present work aimed at evaluating the pattern and distribution HIF-1α GLUT-1 in each case control.A case-control retrospective study was conducted on archival blocks diagnosed from pathology department as, Basal Cell Carcinoma (BCC, 20 cases), cutaneous Squamous (SCC, cases) normal...

Background: Kaposi sarcoma (KS) is a neoplasm of the endothelial cells.It often manifests with multiple vascular nodules on skin and other organs.It systemic, malignant multifactorial disease has variable course.There are four types: classic, endemic, iatrogenic HIV-associated.The primary presentation penis face uncommon mainly observed in HIV-positive patients.Multiple treatment modalities used including surgery, cryotherapy, electrosurgery, laser radiation therapy.Main observation: The...

Aquaporin-3 (AQP3), is an aquaglyceroporin, that plays a role in cell proliferation, tumorigenesis, and migration. This study aimed at evaluating the possible of AQP3 nonmelanoma skin cancer (NMSC) pathogenesis through its immunohistochemical expression biopsies these diseases. One-hundred thirty cutaneous specimens were studied. These included 60 cases NMSC 40 normal 30 psoriasis samples, from age- gender-matched subjects, as control group. was expressed 66.7% basal carcinoma (BCC) 93.3%...

Aquaporin-3 (AQP3) is an aquaglyceroporin that plays a role in skin hydration, cell proliferation, and migration. The aim of this work was to investigate the expression AQP3 sun-exposed sun-protected human from different age groups understand relationship between aging. Using standard immunohistochemical techniques, biopsies were taken 60 normal individuals. expressed basal suprabasal layers, sparing stratum corneum, all specimens. Dermal detected fibroblasts, endothelial cells, adnexa....

There has been a long lasting controversy over whether melanocytes (MCs) in vitiligo are actually lost or still present but functionally inactive. We aimed to evaluate the MC cell lineage follicular and interfollicular vitiliginous epidermis through immunohistochemical localization of Human Melanoma Black-45 (HMB-45) Tyrosinase Related Protein 2 (TRP2) correlate it with clinicopathologic parameters. Using techniques, skin biopsies from 50 patients 20 age- gender-matched healthy subjects were...

Psoriasis is a common dermatologic disease with multifactorial etiology in which genetic factors play major role. Peroxisome proliferator-activated receptor (PPAR)-γ expressed keratinocytes and known to affect cell maturation differentiation addition its role inflammation.To study the association between PPAR-γ gene polymorphism psoriasis vulgaris Egyptian patients explore if this influenced risk or clinical presentation.Forty-five 45 age, sex body mass index matched healthy volunteers who...

Trichoepithelioma (TE) is a benign tumor of follicular origin that presents as small, skin-colored papules predominantly on the face. When more than one family member affected, disease known multiple familial trichoepithelioma (MFT). It rare autosomal dominant (AD) skin disease. Malignant transformation very rare. We present case MFT in female patient and her father with malignant to basal cell carcinoma (BCC) father. summarized main histological differential parameters between TE BCC...

Leptin has been recognized as an important factor for promoting normal cutaneous wound healing. The aim of this work was to explore leptin expression in keloid and hypertrophic scars (HS) compared with surgical skin. relationship clinicopathologic parameters studied cases also evaluated. Using immunohistochemical techniques, analyzed skin biopsies 60 nonobese subjects without metabolic syndrome who presented keloids (20), HS (20). Twenty samples, from age-matched, sex-matched, body mass...

Alopecia areata (AA) is a common dermatologic disease with suspected autoimmune etiology. Tumor necrosis factor superfamily member 6 or CD95 (FAS) and FAS ligand (FASL) are proapoptotic proteins. The relationship between apoptosis autoimmunity well recognized. Inflammatory T cells in AA cytotoxic possess FAS/FASL antigens.This study aims to investigate the association FAS-670 A/G FASL-124 gene polymorphisms clarify if these influence occurrence increase risk.A case-control was conducted on...

Abstract Background Vitiligo is an acquired depigmentaion of skin and hair. The presence white hair within vitiligo lesions considered a bad prognostic sign since these are difficult to repigment. Melanocyte reservoir was not extensively studied in vitiliginous Objective To evaluate pigment cell black Method Using immunohistochemical technique, biopsies from 30 patients (including either or hair) 10 age‐ gender‐matched healthy subjects were examined. Human Melanoma Black‐45 ( HMB ‐45) used...

Skin is a target organ of sex steroids which play important roles in skin health and disease. The aim this study to investigate the expression estrogen receptor β (ERβ) androgen (AR) human from different age groups for better understanding hormonal regulation aging. Using standard immunohistochemical techniques, biopsies sun-unprotected sun-protected were taken 60 normal subjects. Sun-protected showed significantly higher immunoreactivity ERβ AR compared all groups. Significantly H score...

Telogen effluvium (TE) is a form of alopecia characterized by diffuse hair shedding. Vitamin D receptor (VDR) plays role in cycle regulation as it expressed follicular keratinocytes and dermal papilla cells.To investigate the association between Cdx1 Taq1 VDR gene polymorphisms chronic TE.Thirty female patients with TE were selected 30 healthy, age- sex-matched volunteers included control group. Detection was done real-time polymerase chain reaction.Regarding Taq 1, CC genotype present 30%...

Abstract Background Depression is a common psychiatric comorbidity among chronic dermatology patients. There extreme lacking in the research studying biomarkers responsible for it. Both brain‐derived neurotrophic factor (BDNF) and vitamin D have significant role development of depression. Aim To assess BDNF serum levels different clinical verities alopecia areata (AA) vitiligo patients, correlating them with depression prevalence quality life. Methods In all, 30 AA healthy volunteers were...

Androgenetic alopecia (AGA) is a common cause of hair loss in both genders that may be associated with disturbed systemic metabolism. Irisin hormone-like myokine greatly influences metabolism and linked to cardiovascular diseases.To detect irisin role AGA its metabolic syndrome (MetS) risk.This case-control study included 44 patients 22 healthy individuals. Serum level was measured using ELISA scalp biopsy taken immunohistochemically. Carotid Doppler ultrasonography performed measure carotid...

Homozygous familial hypercholesterolemia is an autosomal dominant disorder of lipid metabolism, characterized by reduced clearance low-density lipoprotein-cholesterol and a high risk rapid development cardiovascular diseases. Its incidence relatively rare estimated to be one in million general populations. Here, we report homozygous two Egyptian young siblings, presented with cutaneous, tendinous xanthomas, corneal arcus. One them has symmetric subcutaneous lipomatosis, which not been...

Sperm-associated antigen 9 (SPAG9) is a scaffold protein for c-Jun-NH2-kinases, which play an important role in cell survival, proliferation, apoptosis, and tumor development. SPAG9 was claimed to be involved the pathogenesis of carcinoma different organs. The aim this work investigate its nonmelanoma skin cancer (NMSC) through immunohistochemical (IHC) localization biopsies these tumors. This retrospective prospective study included 67 cutaneous specimens; 42 NMSC [20 cases with basal (BCC)...

Generalized eruptive histiocytoma (GEH) is an uncommon benign disorders of non Langerhan's cell histiocytoses (LCH). 1 It a papular lipidic self healing and affects mainly adults. 2 Clinically, asymptomatic, brown coloured, pale erythematous papules and/or nodules are seen over the entire body. 3he involvement mucosa can also occur. 4The lesions disappear spontaneously without trace or heal leaving pigmentation. 58-year-old female presented with multiple firm asymptomatic hemispherical...

Melasma is a characteristic pattern of facial hyperpigmentation, occurring primarily on the forehead, cheeks, and chin, in mask-like distribution. The pathogenesis melasma not fully understood. Vitamin D plays role skin pigmentation. It exerts its effect through vitamin receptor (VDR), which expressed variable cells including normal melanocytes.The aim current work was to investigate if VDR gene polymorphism (TaqI) confers susceptibility Egyptian patients.A total 45 female patients with were...

Female pattern hair loss (FPHL) is an important cause of in adult women and has a major impact on patient's quality life. It evolves from the progressive miniaturization follicles that leads to subsequent decrease density, leading non-scarring diffuse alopecia, with characteristic clinical, dermoscopic, histological patterns. Vitamin D receptor (VDR) expressed follicular keratinocytes dermal papilla cells shown have role growth regulation cycle. VDR polymorphism was not extensively...

Skin tags (STs) are common benign dermal connective tissue neoplasms that mainly composed of loose fibrous tissue. However, their exact etiology is not fully understood. Leptin a major player in the biology and pathology skin its appendages. It linked to cell differentiation, proliferation, migration, survival with pronounced effects on angiogenesis, blood flow, perfusion. This study aimed at investigating possible role leptin STs pathogenesis correlating expression different clinical...