A5100317491- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- Estrogen and related hormone effects
- DNA Repair Mechanisms
- Breast Lesions and Carcinomas
- Epigenetics and DNA Methylation
- Advanced Breast Cancer Therapies
- BRCA gene mutations in cancer
- Cancer Immunotherapy and Biomarkers
- Gene expression and cancer classification
- Global Educational Policies and Reforms
- Education Systems and Policy
- Monoclonal and Polyclonal Antibodies Research
- Cell Adhesion Molecules Research
- PARP inhibition in cancer therapy
- AI in cancer detection
- Lung Cancer Treatments and Mutations
- Genomics and Chromatin Dynamics
- Genetic factors in colorectal cancer
- Global Education and Multiculturalism
- Social Policy and Reform Studies
- Religious Education and Schools
University of Nottingham
2016-2025
Novartis (Switzerland)
2024-2025
Breast Cancer Research Foundation
2023-2025
Nottingham University Hospitals NHS Trust
2015-2024
Brunel University of London
2009-2024
University of Oxford
2024
Takeda (Singapore)
2023-2024
Children's Health Ireland at Crumlin
2024
Brown University
2017-2024
Northumbria Healthcare NHS Foundation Trust
2024
Breast carcinomas are often infiltrated by inflammatory cells, particularly macrophages and T lymphocytes, but the significance of these cells remains unclear. One possible role is that they represent a cell-mediated immune response against carcinoma. CD8(+) lymphocytes known crucial component immunity. The purpose this study was to explore prognostic value tumor-infiltrating cytotoxic in breast cancer. Tumor-infiltrating were assessed immunohistochemical staining tissue microarray cores...
Abstract BACKGROUND. Triple‐negative breast cancer (estrogen receptor‐negative, progesterone and HER2‐negative) is a high risk that lacks the benefit of specific therapy targets these proteins. METHODS. In this study, authors examined large well characterized series invasive carcinoma (n = 1944) with long‐term clinical follow‐up (median, 56 months) by using tissue microarray. The were also stained concurrent immunohistochemical prognostic panels receptor, HER‐2, androgen epidermal growth...
Abstract Background MicroRNAs (miRNAs), a class of short non-coding RNAs found in many plants and animals, often act post-transcriptionally to inhibit gene expression. Results Here we report the analysis miRNA expression 93 primary human breast tumors, using bead-based flow cytometric profiling method. Of 309 miRNAs assayed, identify 133 expressed tumors. We used mRNA classify tumors as luminal A, B, basal-like, HER2+ normal-like. A number are differentially between these molecular tumor...
Purpose We recently reported that the mRNA-based, 21-gene Genomic Health recurrence score (GHI-RS) provided additional prognostic information regarding distant beyond obtained from classical clinicopathologic factors (age, nodal status, tumor size, grade, endocrine treatment) in women with early breast cancer, confirming earlier reports. The aim of this article is to determine how much contained standard immunohistochemical (IHC) markers. Patients and Methods primary cohort comprised 1,125...
Two stigmatizing attitudes related to dangerousness and personal responsibility may undermine the opportunities of persons with serious mental illness. This study set out examine path models that explain how these lead discriminatory behavior assess impact antistigma programs on components models. hundred thirteen were randomly assigned one five conditions: education responsibility, dangerousness, contact a person illness where is discussed, or no change. Persons completed an attribution...
Nicotinic acid has been used clinically for over 40 years in the treatment of dyslipidemia producing a desirable normalization range cardiovascular risk factors, including marked elevation high density lipoprotein and reduction mortality. The precise mechanism action nicotinic is unknown, although it believed that activation G<sub>i</sub>-G protein-coupled receptor may contribute. Utilizing available information on tissue distribution receptors, we identified candidate orphan receptors....
Post-translational histone modifications are known to be altered in cancer cells, and loss of selected acetylation methylation marks has recently been shown predict patient outcome human carcinoma. Immunohistochemistry was used detect a series lysine (H3K9ac, H3K18ac, H4K12ac, H4K16ac), (H3K4me2 H4K20me3), arginine (H4R3me2) well-characterized breast carcinomas (n = 880). Tissue staining intensities were assessed using blinded semiquantitative scoring. Validation studies done...
Triple-negative (TN; estrogen receptor, progesterone and HER-2 negative) cancer basal-like breast (BLBC) are associated with poor outcome lack the benefit of targeted therapy. It is widely perceived that BLBC TN tumors synonymous can be defined using a definition without need for expression basal markers.We have used two well-defined cohorts cancers large panel biomarkers, BRCA1 mutation status, follow-up data to compare clinicopathologic immunohistochemical features expressing one or more...
Laboratory models show that the beta-blocker, propranolol, can inhibit norepinephrine-induced breast cancer cell migration. We hypothesised patients receiving beta-blockers for hypertension would reduced metastasis and improved clinical outcome. Three patient subgroups were identified from medical records of 466 consecutive female (median age 57, range 28-71) with operable follow-up (>10 years). Two comprised 43 49 hypertensive treated or other antihypertensives respectively, prior to...
Abstract Background The characterization of copy number alteration patterns in breast cancer requires high-resolution genome-wide profiling a large panel tumor specimens. To date, most array comparative genomic hybridization studies have used panels relatively size and high Nottingham Prognostic Index (NPI) that are not as representative demographics. Results We performed an oligo-array-based analysis alterations 171 primary tumors small low NPI, which was therefore more Hierarchical...
Abstract The aim of this study was to assess the morphological characteristics and immunohistochemical profile breast carcinomas with basal myoepithelial phenotypes obtain a better understanding their biological behaviour nature. One thousand nine hundred forty‐four invasive were examined, using tissue microarray (TMA) technology immunohistochemistry, identify those tumours that showed phenotypes, immunophenotype characterized variety markers. In addition, haematoxylin eosin‐stained sections...
Purpose Response to endocrine therapy in breast cancer correlates with estrogen receptor (ER) and progesterone (PgR) status. It is usually easier decide treatment strategies cases of double-positive/-negative phenotypes than single-positive tumors. Patients Methods We have examined a large well-characterized series primary invasive carcinoma (1,944 cases) long-term clinical follow-up hormone data. were stratified according ER PgR expression the study was focused on groups (ER–/PgR+...
Breast cancer is heterogeneous and the existing prognostic classifiers are limited in accuracy, leading to unnecessary treatment of numerous women. B-cell lymphoma 2 (BCL2), an antiapoptotic protein, has been proposed as a marker, but this effect considered relate oestrogen receptor (ER) status. This study aimed test clinical validity BCL2 independent marker.Five studies 11 212 women with early-stage breast were analysed. Individual patient data included tumour size, grade, lymph node...
Smallpox eradication, coordinated by the WHO and certified 40 years ago, led to cessation of routine smallpox vaccination in most countries. It is estimated that over 70% world's population no longer protected against smallpox, through cross-immunity, closely related orthopox viruses such as monkeypox. Monkeypox now a re-emerging disease. endemic yet unconfirmed animal reservoirs sub-Saharan Africa, while its human epidemiology appears be changing. small animals imported from Ghana exotic...
Macrophages constitute a major component of the leucocytic infiltrate tumours. Human studies show an association between tumour-associated macrophages and tumours with poor prognostic features. In breast cancer, presence has been correlated increased angiogenesis prognosis but little information is available about independent role infiltrating carcinomas.This study used immunohistochemistry tissue microarrays to assess density localisation CD68 1322 identify any relationship...
PREDICT is a breast cancer prognostic and treatment benefit model implemented online. The overall fit of the has been good in multiple independent case series, but shown to underestimate specific mortality women diagnosed under age 40. Another limitation use discrete categories for tumour size node status resulting 'step' changes risk estimates on moving between categories. We have refitted using original cohort cases from East Anglia with updated survival time order take into account at...