A5091846363- Cancer Risks and Factors
- Breast Cancer Treatment Studies
- BRCA gene mutations in cancer
- Cancer Genomics and Diagnostics
- Estrogen and related hormone effects
- Global Cancer Incidence and Screening
- Cancer-related Molecular Pathways
- Genomic variations and chromosomal abnormalities
- Breast Lesions and Carcinomas
- PARP inhibition in cancer therapy
- Gene expression and cancer classification
- Cancer Cells and Metastasis
- Cervical Cancer and HPV Research
- DNA Repair Mechanisms
- Genetic factors in colorectal cancer
- HER2/EGFR in Cancer Research
- RNA modifications and cancer
- Advanced Breast Cancer Therapies
- Advanced Proteomics Techniques and Applications
- Metastasis and carcinoma case studies
- Male Breast Health Studies
- Cancer, Lipids, and Metabolism
- Cancer Research and Treatments
- Multiple and Secondary Primary Cancers
- Cancer Immunotherapy and Biomarkers
Fred Hutch Cancer Center
2014-2023
University of Washington
2010-2023
Seattle University
1995-2023
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2002-2021
Cancer Research Center
2002-2021
University of Michigan–Ann Arbor
2006-2019
Insight Genetics (United States)
2019
Myriad Genetics
2019
The University of Texas MD Anderson Cancer Center
2019
Yale Cancer Center
2019
Targeted disruption of the murine p27Kip1 gene caused a dose–dependent increase in animal size without other gross morphologic abnormalities. All tissues were enlarged and contained more cells, although endocrine abnormalities not evident. Thymic hyperplasia was associated with increased T lymphocyte proliferation, cells showed enhanced IL-2 responsiveness vitro. Thus, p27 deficiency may cause cell-autonomous defect resulting proliferation response to mitogens. In spleen, absence selectively...
Abstract BACKGROUND The incidence of anal cancer has increased among both men (160%) and women (78%) from 1973 to 2000 in the U.S. authors conducted a population‐based case–control study examine factors that may account for this increase. METHODS Men ( n = 119 patients) 187 who were diagnosed with between 1986 1998 Seattle area ascertained through local Surveillance, Epidemiology, End Results registry. Control participants 1700) random‐digit telephone dialing. Participants interviewed person...
Background: Among women who practice breast self-examination (BSE), cancers may be detected when they are at an earlier stage and smaller than in do not BSE. However, the efficacy of for decreasing cancer mortality is unproven. This study was conducted to determine whether intensive program BSE instruction will reduce number dying cancer. Methods: From October 1989 through 1991, 266 064 associated with 519 factories Shanghai were randomly assigned a group (132 979 women) or control (133 085...
Interview with Peggy Porter on the increased rate of breast cancer in lower-income countries. (07:03)Download Recent media reports have highlighted increasing incidence low- and middle-income Although disease continues to be most prominent affluent countries, risks both death due are clearly worldwide (see maps). Some 45% more than 1 million new cases diagnosed each year, 55% breast-cancer–related deaths, occur countries.1 Such countries now face challenge effectively detecting treating a...
Abstract Few population‐based case‐control studies have assessed etiologic factors for penile cancer. Past infection with high‐risk human papillomavirus (HPV) is a known risk factor cancer; however, few previous related the HPV DNA status of tumor to potential demographic and behavioral disease or evaluated whether in situ invasive cancer share factors. Little information available on role timing circumcision etiology We conducted study western Washington state that included 137 men...
HERE IS CONSIDERABLE EVIdence from observational studies, 1 and now a randomized controlled trial, the Women's Health Initiative (WHI), 2 that use of combined estrogen progestin hormone replacement therapy (CHRT) is associated with an increased risk breast cancer.Specifically, pooled analysis 51 studies found current users CHRT or alone for 5 years longer had 53% increase in cancer, after 5.2 follow-up WHI reported was statistically nonsignificant 26% cancer risk. However, few have evaluated...
Abstract Previous studies have shown that BRCA1-related breast cancers are often high-grade tumors do not express estrogen receptors, HER2, p27Kip1, or cyclin D1, but p53 and E. In addition, the expression of cytokeratin 5/6 (CK5/6), indicating a basal epithelial phenotype, is frequent in cancer. Here, series 247 cancers, we demonstrate CK5/6 was associated with nearly all features cancer also poor prognosis. parsimonious multivariable proportional hazards model, protein levels E, p53,...
Abstract Background The characterization of copy number alteration patterns in breast cancer requires high-resolution genome-wide profiling a large panel tumor specimens. To date, most array comparative genomic hybridization studies have used panels relatively size and high Nottingham Prognostic Index (NPI) that are not as representative demographics. Results We performed an oligo-array-based analysis alterations 171 primary tumors small low NPI, which was therefore more Hierarchical...
Purpose: This study examines cell surface ROR1 expression in human tumors and normal tissues. is considered a promising target for cancer therapy due to putative tumor-specific expression, multiple groups are developing antibodies and/or chimeric antigen receptor-modified T cells ROR1. On-target, off-tumor toxicity challenge most nonmutated tumor antigens; however, prior studies suggest that absent on tissues.Experimental Design: Our show published lack sensitivity detect endogenous levels...
Background: Younger women (40–49 years) have lower mammographic sensitivity (i.e., greater proportion of cancers detected after a negative mammogram) than older (≥50 years). We explored the effect tumor growth rate, breast density, image quality, and cancer risk factors on in younger women. Methods: studied 576 (n = 73 aged 40–49 years n 503 50 or older) who were diagnosed with invasive between 1988 1993. Interval defined as those within 12 24 months screening mammogram before subsequent...
BACKGROUND Obesity has been shown to affect breast carcinoma prognosis, with the heaviest women having a higher mortality due carcinoma. Few studies have focused on premenopausal or correlation of body mass index (BMI) tumor characteristics related prognosis. METHODS The authors conducted population-based follow-up study for 1177 younger than 45 years age who had invasive ductal diagnosed from 1983 through 1992. Histologic slides and/or tissue were collected pathologic review,...
BACKGROUND: Although mammographic screening is useful for detecting early breast cancer, some tumors are detected in the interval between examinations. This study attempted to characterize fully two different manners. METHODS: Our utilized a case-control design and involved cohort of women undergoing within defined population health maintenance organization (the Group Health Cooperative Puget Sound). Women were classified as having "interval" or " interval-detected" cancers (n = 150) if...
Abstract Little is known about the etiologic profile of triple-negative breast cancer (negative for estrogen receptor/progesterone receptor/human epidermal growth factor), a subtype associated with high mortality and inadequate therapeutic options. We undertook this study to assess risk among women 45 years age younger in relation demographic/lifestyle factors, reproductive history, oral contraceptive use. Study participants were ascertained two previous population-based, case-control...
The efficacy of breast self-examination in helping to reduce mortality from cancer has not been rigorously demonstrated.To assess efficacy, a large, randomized trial was initiated Shanghai, China.From October 1989 1991, 267040 current and retired female employees associated with 520 factories the Shanghai Textile Industry Bureau were randomly assigned on basis factory either instruction group (133375 women) or control (133665 women). women born within period 1925 through 1958. Women given...
Abstract In this study, we performed high-resolution array comparative genomic hybridization with an of 4153 bacterial artificial chromosome clones to assess copy number changes in 44 archival breast cancers. The tumors were flow sorted exclude non-tumor DNA and increase our ability detect gene changes. these tumors, losses more frequent than gains, gains 1q loss 16q the most alterations. We compared based on histologic subtype estrogen receptor (ER) status, i.e., ER-negative infiltrating...
SPARC (Secreted Protein, Acidic and Rich in Cysteine)/osteonectin is a secreted glycoprotein that exhibits restricted expression murine adult embryonic tissues associated with cell migration, matrix mineralization, steroid hormone production, cycle regulation, angiogenesis. We produced monoclonal antibody, MAb SSP2, against Ca(2+)-binding region of evaluated the immunoreactivity normal malignant tissue from 118 human samples. In we found moderate reactivity SSP2 steroidogenic cells,...