A5022133370- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Lymphatic System and Diseases
- Global Cancer Incidence and Screening
- Breast Implant and Reconstruction
- Cancer Cells and Metastasis
- Economic and Financial Impacts of Cancer
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Genomics and Diagnostics
- HER2/EGFR in Cancer Research
- Medical Imaging Techniques and Applications
- Cancer and Skin Lesions
- Cancer Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Optical Imaging and Spectroscopy Techniques
- Global Public Health Policies and Epidemiology
- Advances in Oncology and Radiotherapy
- Cancer Risks and Factors
- Cancer survivorship and care
- Terahertz technology and applications
- Systemic Sclerosis and Related Diseases
- Spectroscopy and Laser Applications
- MRI in cancer diagnosis
- Ultrasound and Hyperthermia Applications
- Body Contouring and Surgery
Guy's and St Thomas' NHS Foundation Trust
2014-2025
Guy's Hospital
2008-2025
King's College London
2016-2025
National Health Service
2016-2024
St Thomas' Hospital
2011-2024
London Cancer
2013-2024
University of Bristol
2024
Kings Health Partners
2010-2022
Tata Trusts
2018-2021
Cancer Research UK
2013-2019
Purpose Axillary lymph node dissection (ALND) as part of surgical treatment for patients with breast cancer is associated significant morbidity. Sentinel biopsy (SLNB) a newly developed method staging the axilla and has potential to avoid an ALND in node–negative patients, thereby minimizing The aim this study was investigate physical psychological morbidity after SLNB early randomized controlled trial. Patients Methods Between November 1999 February 2003, 298 (tumors 3 cm or less on...
The complex refractive indices of freshly excised healthy breast tissue and cancers collected from 20 patients were measured in the range 0.15 - 2.0 THz using a portable terahertz pulsed transmission spectrometer. Histology was performed to classify samples as adipose tissue, fibrous or cancers. average index determined for each group it found that containing cancer had higher absorption coefficient. properties tissues also used simulate impulse response functions expected when imaging...
The feasibility of using terahertz pulsed imaging to map margins exposed breast tumors was investigated by 22 excised human tissue specimens with carcinoma from women (mean age, 59 years; range, 39–80 years). study approved the local ethics research committee, and informed consent obtained all patients. size shape tumor regions on images were compared those identified at histopathologic examination imaged section. Two image parameters investigated: minimum impulse function ratio maximum...
<b>Glenn Robert and colleagues</b> describe an approach that aims to ensure healthcare organisations realise the full potential of patients—the biggest resource they have for improving quality care
Abstract Background Women with axillary sentinel lymph node (SLN)-positive breast cancer usually undergo completion dissection (ALND). However, not all patients positive SLNs have further nodal disease. Therefore, in the low risk of disease, ALND could be avoided. The Memorial Sloan-Kettering Cancer Center (MSKCC) developed a nomogram to estimate non-SLN This study critically appraised and refined model improve predictive accuracy. Methods MSKCC was applied 118 SLN biopsy who subsequently...
The identification of mammary epithelial stem cells raises the hypothesis that these may be crucial in pathogenesis breast cancer. To further support this, a highly tumourigenic sub-population cancer has recently been identified primary and metastatic samples. In this study, displaying features normally attributed to was within cell line MCF-7. This is capable growth anchorage-independent conditions as spherical organoids, displays resistance proapoptotic agents significantly greater...
Mortality of patients with breast cancer is due overwhelmingly to metastatic spread the disease. Although dissemination an early event in cancer, extended periods cell dormancy can result long latency metastasis development. Deciphering mechanisms underlying and subsequent growth at site would facilitate development strategies interfere these processes. A challenge this undertaking has been lack models for dormancy. We have established novel experimental systems that model bone...
In early-stage breast cancer, the primary treatment option for most women is breast-conserving surgery (BCS). There a clear need more accurate techniques to assess resection margins intraoperatively, because on average 20% of patients require further achieve margins. Cerenkov luminescence imaging (CLI) combines optical and molecular by detecting light emitted <sup>18</sup>F-FDG. Its high-resolution small size equipment make CLI promising technology intraoperative margin assessment. A...
Abstract DNA methylation is aberrant in cancer, but the dynamics, regulatory role and clinical implications of such epigenetic changes are still poorly understood. Here, reduced representation bisulfite sequencing (RRBS) profiles 1538 breast tumors 244 normal tissues from METABRIC cohort reported, facilitating detailed analysis within a rich context genomic, transcriptional, data. Tumor immune stromal signatures deconvoluted leading to discovery tumor replication-linked clock with...