A5042417677- Medical Imaging Techniques and Applications
- Optical Imaging and Spectroscopy Techniques
- Radiation Detection and Scintillator Technologies
- Advanced Radiotherapy Techniques
- Advanced Vision and Imaging
- Nanoplatforms for cancer theranostics
- Magnetic properties of thin films
- Advanced Biosensing Techniques and Applications
- Nuclear Physics and Applications
- Atomic and Subatomic Physics Research
- Advanced biosensing and bioanalysis techniques
- Image Processing Techniques and Applications
- Robotics and Sensor-Based Localization
- Innovative Microfluidic and Catalytic Techniques Innovation
- Prostate Cancer Diagnosis and Treatment
- Microfluidic and Bio-sensing Technologies
- Advanced Image Processing Techniques
- Molecular Junctions and Nanostructures
- Breast Cancer Treatment Studies
- Radiation Therapy and Dosimetry
- Intraperitoneal and Appendiceal Malignancies
- Minimally Invasive Surgical Techniques
- Biosensors and Analytical Detection
- Prostate Cancer Treatment and Research
- Characterization and Applications of Magnetic Nanoparticles
GW Pharmaceuticals (United Kingdom)
2024
Lightpoint Medical (United Kingdom)
2018-2023
University of Cambridge
2009-2020
Indian Institute of Engineering Science and Technology, Shibpur
2018
Sagentia (United Kingdom)
2015-2016
In early-stage breast cancer, the primary treatment option for most women is breast-conserving surgery (BCS). There a clear need more accurate techniques to assess resection margins intraoperatively, because on average 20% of patients require further achieve margins. Cerenkov luminescence imaging (CLI) combines optical and molecular by detecting light emitted <sup>18</sup>F-FDG. Its high-resolution small size equipment make CLI promising technology intraoperative margin assessment. A...
Abstract Purpose Currently, approximately 11–38% of prostate cancer (PCa) patients undergoing radical prostatectomy have a positive surgical margin (PSM) on histopathology. Cerenkov luminescence imaging (CLI) using 68 Ga-prostate-specific membrane antigen ( Ga-PSMA) is novel technique for intraoperative assessment. The aim this first-in-man study was to investigate the feasibility Ga-PSMA CLI . In study, defined as ability distinguish between and negative margin, within 45 min low radiation...
Surgical instrument segmentation and depth estimation are crucial steps to improve autonomy in robotic surgery. Most recent works treat these problems separately, making the deployment challenging. In this paper, we propose a unified framework for surgical tool laparoscopic images. The network has an encoder-decoder architecture comprises two branches simultaneously performing segmentation. To train end end, new multi-task loss function that effectively learns estimate unsupervised manner,...
Arrays of interacting 2D nanomagnets display unprecedented electromagnetic properties via collective effects, demonstrated in artificial spin ices and magnonic crystals. Progress toward 3D magnetic metamaterials is hampered by two challenges: fabricating structures near intrinsic length scales (sub-100 nm) visualizing their configurations. Here, we fabricate measure nanoscale gyroids, periodic chiral networks comprising nanowire-like struts forming three-connected vertices. Via block...
Purpose This study evaluated the performance of a drop-in gamma probe for prostate cancer (PCa) sentinel lymph node dissection (SLND) in pelvic phantom, porcine model, and PCa patients as part an ongoing prospective multicenter clinical trial. Methods Two design variants (SENSEI; Lightpoint Medical Ltd) were assessed preferred was model with clinically representative volumes 99m Tc activities. In trial, radical prostatectomy, SLND, extended performed day after Tc-nanocolloid injection...
Abstract Background Cerenkov Luminescence Imaging (CLI) is an emerging technology for intraoperative margin assessment. Previous research only evaluated radionuclide 18-Fluorine ( 18 F); however, future applications in prostate cancer, 68-Gallium 68 Ga) seems more suitable, given its higher positron energy. Theoretical calculations predict that Ga should offer a signal-to-noise ratio than F; this the first experimental confirmation. The aim of study to investigate technical performance CLI...
Abstract Purpose In surgical oncology, complete cancer resection and lymph node identification are challenging due to the lack of reliable intraoperative visualization. Recently, endoscopic radio-guided has been introduced where a novel tethered laparoscopic gamma detector can be used determine location tracer activity, which complement preoperative nuclear imaging data imaging. However, these probes do not clearly indicate on tissue surface activity originates, making localization...
We describe proof-of-principle experiments and theory that demonstrate a new method of performing multiplexed biological assays by using microscopic tags which carry multi-bit magnetic codes to label probe biomolecules.It is demonstrated these "micro-barcode tags" can be encoded, transported micro-fluidics are compatible with surface chemistry.We also present simulations experimental results suggest the feasibility decoding micro-barcode magnetoresistive sensors.Together, substantial...
Introduction: Cerenkov luminescence imaging (CLI) is a novel technology that might have the ability to assess surgical margins intra-operatively during prostatectomy using Gallium-68 prostate-specific membrane antigen ([<sup>68</sup>Ga]Ga-PSMA-11). This study evaluates accuracy of CLI compared histopathology and as exploratory objective investigates characteristics identified chemiluminescence signal. <b> Materials Methods:</b> After intravenous injection mean <sup>68</sup>Ga-PSMA-11...
Microarrays and suspension-based assay technologies have attracted significant interest over the past decade with applications ranging from medical diagnostics to high throughput molecular biology. The sensitivity of a microarray will always be limited by array density slow reaction kinetics. Suspension (or bead) based offer conceptually different approach, improving detection substituting fixed plane operation many individually distinguishable microcarriers. In addition all features...
Microarrays and suspension-based assay technologies have attracted significant interest over the past decade with applications ranging from medical diagnostics to high throughput molecular biology. The sensitivity of a microarray will always be limited by array density slow reaction kinetics. Suspension (or bead) based offer conceptually different approach, improving detection substituting fixed plane operation millions microcarriers. However, these are currently number unique labels that...
A composite element (CE) bit design for magnetically encoded microcarriers provides an increased coercivity range longer codes as well significant improvements to encoding density, reliability and read-out.
IPv6 Routing Protocol for Low Power and Lossy Networks (RPL) proposed by Internet Engineering Task Force (IETF) has been adopted to suit of Things (IoT) requirements. However, both the storing non-storing modes operation RPL brings about certain limitations. In case mode RPL, if an intermediate node along routing path overflows, new nodes become unreachable whereas, entire topology is only saved at root resulting in increased congestion near root. Therefore, this paper, we propose a low...
Abstract Introduction In women undergoing breast-conserving surgery (BCS), 20–25% require a re-operation as result of incomplete tumour resection. An intra-operative technique to assess margins accurately would be major advantage. A novel method for intraoperative margin assessment was developed by applying thin flexible scintillating film specimens—flexible autoradiography (FAR) imaging. single-arm, multi-centre study conducted evaluate the feasibility [ 18 F]FDG FAR in BCS. Methods...
SU8 microcarriers containing magnetic thin film (40 nm cobalt) elements were fabricated by photolithography and thermal evaporation, included a gold coating on the base. The microcarriers, which can be encoded with barcode for later identification in multiplexed suspension assay, now possess two distinct surfaces further chemical derivitization. This allows us to attach different bio-molecules each side, we suggest, could used add positive control typical hybridization assays as test binding...
The magnetotactic bacterium Magnetospirillum sp. has been cultured and the properties of its endogenous magnetic nanoparticles characterized. Electron-microscopic analyses indicate that magnetite in are coated with a 3–4 nm thick transparent shell, forming magnetosome. These had diameters 50.9±13.3 nm, good agreement diameter 40.6±1.2 extracted from magnetometry. Each contained chains 5–25 magnetosomes. Superconducting quantum interference device magnetometry results extrinsic...
Autoradiography potentially offers high molecular sensitivity and spatial resolution for tumor margin estimation. However, conventional autoradiography requires sectioning the sample which is destructive labor-intensive. Here we describe a novel technique that uses flexible ultra-thin scintillator conforms to surface. Imaging with enables direct, high-resolution high-sensitivity imaging of beta particle emissions from targeted radiotracers. The has potential identify positive margins in...
Microarrays and suspension-based technologies have attracted significant interest over the past decade with applications in medical diagnostics biochemical multiplexed assays. However, throughput of microarrays will always be limited by array density slow kinetics, while suspension (or bead)-based are currently number distinct codes beads can carry. A novel digital magnetic tagging technology based on tags that used as encoded microcarriers for biomolecular probes, is presented here. The...