A5010429902- Economic and Financial Impacts of Cancer
- Cancer survivorship and care
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Genomics and Diagnostics
- Breast Cancer Treatment Studies
- BRCA gene mutations in cancer
- Ethics in Clinical Research
- Childhood Cancer Survivors' Quality of Life
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Biomedical Ethics and Regulation
- Advanced Breast Cancer Therapies
- Palliative Care and End-of-Life Issues
- Global Cancer Incidence and Screening
- Medication Adherence and Compliance
- Cancer Risks and Factors
- Cancer-related cognitive impairment studies
- Genetic factors in colorectal cancer
- Family Support in Illness
- Estrogen and related hormone effects
- Pharmacogenetics and Drug Metabolism
- Reproductive Biology and Fertility
- Cancer Immunotherapy and Biomarkers
- Lymphatic System and Diseases
- Patient-Provider Communication in Healthcare
Harvard University
2016-2025
Massachusetts General Hospital
2016-2025
Concord Hospital
2024
Dana-Farber/Harvard Cancer Center
2022-2024
Dana-Farber Cancer Institute
2007-2023
Center for Practical Bioethics
2022
Duke University
2009-2020
University of Ulsan
2020
Asan Medical Center
2020
Ulsan College
2020
An American Society of Clinical Oncology (ASCO) provisional clinical opinion (PCO) offers timely direction to ASCO's membership following publication or presentation potentially practice-changing data from major studies. This PCO addresses the integration palliative care services into standard oncology practice at time a person is diagnosed with metastatic advanced cancer.Palliative frequently misconstrued as synonymous end-of-life care. Palliative focused on relief suffering, in all its...
Describe the experiences of insured cancer patients requesting copayment assistance in order to better understand challenges underinsurance. impact costs on well being patients. Evaluate treatment received by Cancer carry rising burdens health care‐related out‐of‐pocket expenses, and a growing number are considered "underinsured." Our objective was describe care expenses well‐being treatment. We conducted baseline follow‐up surveys regarding among who contacted national foundation along with...
Health care costs in the United States present a major challenge to national economic well being. The Centers for Medicare and Medicaid Services (CMS) has projected that US health spending will reach $4.3 trillion account 19.3% of gross domestic product by 2019.1 This growth spending—both absolute terms as proportion our product—has not been accompanied commensurate improvements outcomes, despite expenditures far exceeding those other countries.2–4 One fastest growing components is cancer...
Young women with breast cancer often seek advice about whether treatment will affect their fertility. We sought to gain a better understanding of women's attitudes fertility and how these concerns decision making.We developed survey issues for young history early-stage cancer. The was e-mailed all registered Survival Coalition survivor members (N = 1,702). E-mail reminders were used.Six hundred fifty-seven eligible respondents completed the survey. Mean age at diagnosis 32.9 years; mean...
The mission of American Society Clinical Oncology (ASCO) is to conquer cancer through research, education, and promotion the highest quality patient care. Toward fulfillment this goal at direction its board directors, ASCOValue in Cancer Care Task Force set out develop a framework that would enable physician assess value particular treatment regimen given patient’s individual preferences circumstances. rationale served as impetus for initiative many faceted. Substantial progress has been...
Patients with advanced incurable cancer face complex physical, psychological, social, and spiritual consequences of disease its treatment. Care for these patients should include an individualized assessment the patient's needs, goals, preferences throughout course illness. Consideration disease-directed therapy, symptom management, attention to quality life are important aspects care. However, emerging evidence suggests that, too often, realistic conversations about prognosis, potential...
A key component of informed consent to participate in medical research includes understanding that is not the same as treatment.
Little is known about the association between patient-oncologist discussion of cancer treatment out-of-pocket (OOP) cost and medication adherence, a critical component quality care.We surveyed insured adults receiving anticancer therapy. Patients were asked if they had discussed OOP with their oncologist. Medication nonadherence was defined as skipping doses or taking less than prescribed to make prescriptions last longer, not filling because cost. Multivariable analysis assessed...
The NCCN Guidelines for Survivorship provide screening, evaluation, and treatment recommendations common physical psychosocial consequences of cancer to help healthcare professionals who work with survivors adult-onset in the posttreatment period. This portion guidelines describes regarding management anthracycline-induced cardiotoxicity lymphedema. In addition, immunizations prevention infections are included.
Antibiotic exposure before immune checkpoint inhibitor (ICI) treatment can negatively affect outcomes through alteration in the gut microbiome, but large-scale evaluations are lacking. We performed a population-level retrospective cohort study to evaluate impact of antibiotic starting ICI on overall survival (OS).Patients with cancer, age 65 years or older, who initiated ICIs between June 2012 and October 2018 Ontario, Canada, were identified using systemic therapy administration data. The...
We examined the feasibility of using CYP2D6 genotyping to determine optimal tamoxifen dose and investigated whether key active metabolite, endoxifen, could be increased by genotype-guided dosing in patients with intermediate metabolism.One hundred nineteen on 20 mg daily ≥ 4 months not any strong inhibiting medications were assayed for genotype plasma metabolite concentrations. Patients found extensive metabolizers (EM) remained those (IM) or poor (PM) 40 daily. Eighty-nine evaluable had...
Background. To evaluate the safety and efficacy of moderate-to-high intensity aerobic training in breast cancer patients receiving neoadjuvant chemotherapy. Methods. Twenty with stage IIB–IIIC operable were randomly assigned to receive doxorubicin plus cyclophosphamide (AC) or AC combination (AC + AET) (n = 10/group) for 12 weeks. The AC+ AET group performed three supervised cycle ergometry sessions per week at 60%–100% exercise capacity (VO2peak). Safety outcomes included testing as well...
Many cancer survivors experience menopausal symptoms, including female taking aromatase inhibitors or with a history of oophorectomy chemotherapy, and male who received are receiving androgen-ablative therapies. Sexual dysfunction is also common in survivors. menopause-related symptoms can increase distress have significant negative impact on quality life. This portion the NCCN Guidelines for Survivorship provide recommendations screening, evaluation, treatment sexual to help healthcare...
This cross-sectional survey study examines financial distress and cost expectations among patients with cancer presenting for anticancer therapy.
Abstract Background. Health care-related costs and satisfaction are compelling targets for quality improvement in cancer care delivery; however, little is known about how financial burden affects patient satisfaction. Methods. This was an observational, cross-sectional, survey-based study assessing patient-reported (FB). Eligible patients were ≥21 years with solid tumor malignancy receiving chemotherapy or hormonal therapy ≥1 month. The Patient Satisfaction Questionnaire Short-Form assessed...
Abstract Aerobic exercise training (AET) is an effective adjunct therapy to attenuate the adverse side-effects of adjuvant chemotherapy in women with early breast cancer. Whether AET interacts antitumor efficacy has received scant attention. We carried out a pilot study explore effects combination neoadjuvant doxorubicin–cyclophosphamide (AC+AET), relative AC alone, on: (i) host physiology [exercise capacity (VO2 peak), brachial artery flow-mediated dilation (BA-FMD)], (ii) host-related...
<h3>Importance</h3> Young women with breast cancer are increasingly choosing bilateral mastectomy (BM), yet little is known about short-term and long-term physical psychosocial well-being following surgery in this population. <h3>Objective</h3> To evaluate the differential associations of quality life (QOL) outcomes from 1 to 5 years diagnosis. <h3>Design, Setting, Participants</h3> Cohort study <h3>Setting</h3> Multicenter, including academic community hospitals North America...