A5052326023- Ovarian cancer diagnosis and treatment
- Intraperitoneal and Appendiceal Malignancies
- Cancer survivorship and care
- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Childhood Cancer Survivors' Quality of Life
- Appendicitis Diagnosis and Management
- Cancer Treatment and Pharmacology
- Endometriosis Research and Treatment
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
- Sexual function and dysfunction studies
- Hepatitis B Virus Studies
- Neuroendocrine Tumor Research Advances
- Hernia repair and management
- Advances in Oncology and Radiotherapy
- Cancer-related cognitive impairment studies
- Uterine Myomas and Treatments
- Pelvic floor disorders treatments
- Renal cell carcinoma treatment
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Surgical Treatments
- Cytokine Signaling Pathways and Interactions
- Chemotherapy-induced organ toxicity mitigation
City of Hope
2012-2024
Regeneron (United States)
2021-2024
City Of Hope National Medical Center
2014-2023
National Cancer Center
2017
Gynecologic Oncology Group
2016
Beckman Research Institute
2013-2014
University of Alabama at Birmingham
2014
Roswell Park Comprehensive Cancer Center
2014
St. Jude Children's Research Hospital
2014
University of Tennessee Health Science Center
2014
The NCCN Guidelines for Survivorship provide screening, evaluation, and treatment recommendations common physical psychosocial consequences of cancer to help healthcare professionals who work with survivors adult-onset in the posttreatment period. This portion guidelines describes regarding management anthracycline-induced cardiotoxicity lymphedema. In addition, immunizations prevention infections are included.
Abstract Human papillomavirus (HPV), the primary cause of cervical cancer, is also associated with development anal cancer. Relatively little known about epidemiology HPV infection among healthy females and its relationship to infection. We sought characterize in a cohort adult women Hawaii. Overall, 27% (372 1,378) were positive for DNA at baseline compared 29% (692 2,372) DNA. Among paired samples, without accompanying was observed 14% (190 1,363). Concurrent infections 13% (178 1,363)...
Many cancer survivors experience physical and/or psychosocial side effects, which can be severe, debilitating, and sometimes permanent. These NCCN Guidelines for Survivorship provide screening, evaluation, treatment recommendations common consequences of health care professionals who work with adult-onset in the posttreatment period. introductory sections guidelines include panel's definition survivors, a discussion effects its treatment, general principles standards survivorship care,...
The role of B cells in cancer and the underlying mechanisms remain to be further explored. Here, we show that tumor-associated with activated STAT3 contribute tumor development by promoting angiogenesis. or without Stat3 have opposite effects on growth angiogenesis both B16 melanoma Lewis Lung Cancer mouse models. Ex vivo assays cell-mediated is mainly dependent induction pro-angiogenic gene expression, which requires signaling cells. Furthermore, are found near vasculature correlate...
Many cancer survivors experience menopausal symptoms, including female taking aromatase inhibitors or with a history of oophorectomy chemotherapy, and male who received are receiving androgen-ablative therapies. Sexual dysfunction is also common in survivors. menopause-related symptoms can increase distress have significant negative impact on quality life. This portion the NCCN Guidelines for Survivorship provide recommendations screening, evaluation, treatment sexual to help healthcare...
Abstract BACKGROUND: Several publications reporting on health disparities document that ethnic minorities disproportionately experience delays in healthcare access, delivery, and treatment. However, few studies examine factors underlying access receipt of among cancer survivors from the patient perspective. This study explores diagnostic therapeutic care a multiethnic sample breast cervical examines contextual influencing delays. METHODS: Population‐based sampling cross‐sectional design were...
The NCCN Guidelines for Survivorship provide screening, evaluation, and treatment recommendations common consequences of cancer treatment. They are intended to aid health care professionals who work with survivors adult-onset in the posttreatment period, including those general oncology, specialty survivor clinics, primary practices. Guidance is also provided help promote physical activity, weight management, proper immunizations survivors. This article summarizes panel's discussions 2016...
Abstract JAK/STAT3 is one of the major signaling pathways that aberrantly activated in ovarian cancer and associated with tumor progression poor prognosis patients cancer. In this study, we evaluated therapeutic potential targeting using a peritoneal dissemination mouse model. We developed model by injecting metastatic human cell line, SKOV3-M-Luc, into cavity immunodeficient mice. This displayed phenotype similar to late-stage cancer, including extensive metastasis ascites production. The...
Background Several previous studies have identified a strong association between T-cell infiltration and clinical outcome in ovarian cancer. The role of B-cells remains controversial, however. Methods Forty-nine paraffin-embedded omental specimens derived from patients with high grade epithelial cancer were assessed. Immunohistochemical analyses performed to characterize expression CD19+ pSTAT3 as (>50% positively staining cells [PSCs]) or low (<50% PSCs). Kaplan-Meier method log-rank test...
Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal cancers can be associated significant complications. Randomized trials have demonstrated increased morbidity liberal fluid regimens in abdominal surgery.To investigate the association of intraoperative administration and patients undergoing CRS/HIPEC.A retrospective analysis information from a prospectively collected institutional database was conducted at National Cancer Institute-designated...
Cognitive impairment is a common complaint among cancer survivors and may be consequence of the tumors themselves or direct effects cancer-related treatment (eg, chemotherapy, endocrine therapy, radiation). For some survivors, symptoms persist over long term and, when more severe, can impact quality life function. This section NCCN Guidelines for Survivorship provides assessment, evaluation, management recommendations cognitive dysfunction in survivors. Nonpharmacologic interventions...
Healthy lifestyle habits have been associated with improved health outcomes and quality of life and, for some cancers, a reduced risk recurrence death. The NCCN Guidelines Survivorship therefore recommend that cancer survivors be encouraged to achieve maintain healthy lifestyle, attention weight management, physical activity, dietary habits. This section the focuses on recommendations regarding activity in survivors, including assessment exercise-induced adverse events, exercise...
New therapeutic modalities are needed for ovarian cancer, the most lethal gynecologic malignancy. Recent clinical trials have demonstrated impressive potential of adoptive therapy using chimeric antigen receptor (CAR)-redirected T cells to target hematological cancers, and emerging studies suggest a similar impact may be achieved solid cancers. We sought determine whether genetically-modified targeting CE7-epitope L1-CAM, cell adhesion molecule aberrantly expressed in several promise as an...
Immunotherapy is emerging as one of the most effective methods for treating many cancers. However, immunotherapy can still introduce significant off-target toxicity, and are sought to enable targeted at tumor sites. Here, we show that relatively large (>100-nm) anionic nanoparticles administered intraperitoneally (i.p.) selectively accumulate in tumor-associated macrophages (TAMs). In a mouse model metastatic ovarian cancer, fluorescently labeled silica, poly(lactic-co-glycolic acid),...
Hyperthermic intraperitoneal chemotherapy (HIPEC) confers a survival benefit in epithelial ovarian cancer (EOC) and preclinical models. However, the molecular changes induced by HIPEC have not been corroborated humans.A feasibility trial evaluated clinical safety outcomes of with cisplatin during optimal cytoreductive surgery (CRS) patients EOC diagnosed stage III, IV, or recurrent EOC. Pre- post-HIPEC biopsies were comprehensively profiled genomic transcriptomic sequencing to identify...
Healthy lifestyle habits have been associated with improved health outcomes and quality of life and, for some cancers, a reduced risk recurrence death. The NCCN Guidelines Survivorship therefore recommend that cancer survivors be encouraged to achieve maintain healthy lifestyle, including attention weight management, physical activity, dietary habits. This section the focuses on recommendations regarding nutrition, supplement use in survivors. Weight management are based survivor's body mass...
Sleep disorders, including insomnia and excessive sleepiness, affect a significant proportion of patients with cancer survivors, often in combination fatigue, anxiety, depression. Improvements sleep lead to improvements mood, quality life. This section the NCCN Guidelines for Survivorship provides screening, diagnosis, management recommendations disorders survivors. Management includes combinations hygiene education, physical activity, psychosocial interventions, pharmacologic treatments.
Many posttreatment cancer survivors experience chronic pain, often leading to psychological distress; decreased activity, motivation, and personal interactions; an overall poor quality of life. This section the NCCN Guidelines for Survivorship provides screening management recommendations pain in survivors. A multidisciplinary approach is recommended, with a combination pharmacologic treatments, psychosocial behavioral interventions, physical therapy exercise, interventional procedures.