A5024612727- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Malaria Research and Control
- Childhood Cancer Survivors' Quality of Life
- Global Maternal and Child Health
- Mosquito-borne diseases and control
- Acute Myeloid Leukemia Research
- Cancer survivorship and care
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Polyomavirus and related diseases
- Hemoglobinopathies and Related Disorders
- Sarcoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Family Support in Illness
- Immunodeficiency and Autoimmune Disorders
- Autoimmune and Inflammatory Disorders Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Emergency and Acute Care Studies
- Transplantation: Methods and Outcomes
- Immune Cell Function and Interaction
- Renal Transplantation Outcomes and Treatments
- Chronic Myeloid Leukemia Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neutropenia and Cancer Infections
Malaria Consortium
2017-2025
Fred Hutch Cancer Center
2016-2025
Karolinska Institutet
2017-2025
University of Washington
2013-2025
Takeda (United States)
2025
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2011-2024
Seattle Children's Hospital
2001-2023
University of Mississippi Medical Center
2023
St Andrew's Healthcare
2023
Black Country Partnership NHS Foundation Trust
2023
The NCCN Guidelines for Survivorship provide screening, evaluation, and treatment recommendations common physical psychosocial consequences of cancer to help healthcare professionals who work with survivors adult-onset in the posttreatment period. This portion guidelines describes regarding management anthracycline-induced cardiotoxicity lymphedema. In addition, immunizations prevention infections are included.
The NCCN Guidelines for Survivorship are intended to help healthcare professionals address the complex and varied needs of cancer survivors. provide screening, evaluation, treatment recommendations psychosocial physical problems resulting from adult-onset its treatment; promote healthy behaviors immunizations in survivors; a framework care coordination. These Insights summarize recent guideline updates panel discussions pertaining sleep disorders, fatigue, cognitive function
As hematopoietic cell transplantation (HCT) and cellular therapy expand to new indications international access improves, the number of HCTs performed annually continues rise. Parallel improvements in HCT techniques supportive care entails more patients surviving long term, creating further emphasis on survivorship needs. Survivors are at risk for developing late complications secondary pretransplantation, peritransplantation, post-transplantation exposures other underlying factors....
Background Ethiopia is one of the countries with highest burden neglected tropical diseases (NTDs), 16 20 recognised NTDs considered a public health problem, twelve which have been identified as priorities by Ethiopian Federal Ministry Health. However, until recently not received adequate attention at national and subnational levels in country. This study assessed feasibility, acceptability, cost-effectiveness an NTD intervention when integrated into primary care system Ethiopia. Methods was...
Background: Hematopoietic stem cell transplantation (HSCT) is increasingly used to treat multiple malignant and nonmalignant conditions. The risk for cardiovascular disease after the procedure has not been well-described. Objective: To compare rates hazards of cardiovascular-related hospitalization death among persons who were still alive at least 2 years HSCT with those in a population-based sample. Design: Retrospective cohort study. Setting: Comprehensive cancer center. Patients: 1491...
Success of hematopoietic cell transplantation (HCT) can vary by race, but the impact socioeconomic status (SES) is not known. To evaluate role race and SES, we studied 6207 unrelated-donor myeloablative (MA) HCT recipients transplanted between 1995 2004 for acute or chronic leukemia myelodysplastic syndrome (MDS). Patients were reported transplant center to be White (n = 5253), African American 368), Asian/Pacific-Islander 141), Hispanic 445). Patient income was estimated from residential...
Many cancer survivors experience menopausal symptoms, including female taking aromatase inhibitors or with a history of oophorectomy chemotherapy, and male who received are receiving androgen-ablative therapies. Sexual dysfunction is also common in survivors. menopause-related symptoms can increase distress have significant negative impact on quality life. This portion the NCCN Guidelines for Survivorship provide recommendations screening, evaluation, treatment sexual to help healthcare...
Personalizing intravenous busulfan doses to a target plasma concentration at steady state (Css) is an essential component of hematopoietic cell transplantation (HCT). We sought develop population pharmacokinetic model predict i.v. over wide age spectrum (0.1-66 years) that accounts for differences in and body size.A based on normal fat mass maturation postmenstrual was built from 12,380 time points obtained after administration 1,610 HCT recipients. Subsequently, simulation results the...
To determine the influence of modifiable lifestyle factors on risk cardiovascular disease after hematopoietic cell transplantation (HCT).HCT survivors ≥ 1 year treated from 1970 to 2010 (n = 3,833) were surveyed 2011 current health and related (smoking, diet, recreational physical activity). Responses 2,362) compared with those a matched general population sample (National Health Nutrition Examination Survey [NHANES]; n 1,192).Compared NHANES participants, HCT (median age, 55.9 years; median...
The NCCN Guidelines for Survivorship provide screening, evaluation, and treatment recommendations consequences of adult-onset cancer its treatment, with the goal helping healthcare professionals who work survivors, including those in primary care. guidelines also to help clinicians promote physical activity, weight management, proper immunizations survivors facilitate care coordination ensure that all survivors’ needs are addressed. These Insights summarize additions changes made 2020...
The NCCN Guidelines for Survivorship provide screening, evaluation, and treatment recommendations consequences of cancer to aid healthcare professionals who work with survivors adult-onset cancer. Guidance is also provided help promote physical activity, weight management, proper immunizations in facilitate care coordination ensure that all needs are addressed. These Insights summarize some the topics discussed by Panel during 2019 update guidelines, including survivorship population...
Abstract Background Until recently, due to widespread prevalence of molecular markers associated with sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ) resistance in east southern Africa, seasonal malaria chemoprevention (SMC) has not been used at scale this region. This study assessed the protective effectiveness monthly administration SP + AQ (SPAQ) children aged 3–59 months Karamoja sub-region, Uganda, where parasite is assumed be high transmission seasonal. Methods A two-arm...
Abstract The frequency of drug-induced liver injury (DILI) in clinical trials remains a challenge for drug developers despite advances human hepatotoxicity models and improvements reducing liver-related attrition preclinical species. TAK-994, an oral orexin receptor 2 agonist, was withdrawn from phase II due to the appearance severe DILI. Here, we investigate likely mechanism TAK-994 DILI hepatic cell culture systems examined cytotoxicity, mitochondrial toxicity, impact on transporter...
Abstract In this investigation, we selected PAX3 / FKHR and PAX7 fusion transcript–positive –negative alveolar rhabdomyosarcomas (ARMSs) embryonal (ERMSs) with without anaplastic features, to ascertain genomic imbalance differences and/or similarities within these histopathologic genetic rhabdomyosarcoma (RMS) variants. Comparative hybridization (CGH) fluorescence in situ (FISH) studies were performed on 45 specimens consisting of 23 ARMSs 22 ERMSs (12 ERMS cases included from an earlier...
PURPOSE: To compare failure-free survival (FFS) and for patients with local or regional embryonal rhabdomyosarcoma treated on the Intergroup Rhabdomyosarcoma Study (IRS)–IV that of comparable IRS-III. PATIENTS AND METHODS: Patients were retrospectively classified as low- intermediate-risk. Low-risk defined those primary tumors at favorable sites, completely resected microscopic residual, orbit/eyelid primaries gross residual disease less than 5 cm unfavorable sites but resected....
A comparative genomic hybridization (CGH) approach provides identification of gains and losses in a tumor specimen single experiment. Only 11 embryonal rhabdomyosarcomas (E-RMS) have previously been subjected to CGH. The underlying genetic events this histologic subtype are not well defined. In investigation, 12 E-RMS specimens from 10 patients entered into Intergroup Rhabdomyosarcoma Study (IRS) I-IV two local were analyzed by CGH fluorescence situ (FISH). Gains chromosomes or chromosomal...