A5054366044- Malaria Research and Control
- Mosquito-borne diseases and control
- Global Maternal and Child Health
- Parasites and Host Interactions
- Travel-related health issues
- Viral Infections and Vectors
- Computational Drug Discovery Methods
- Hepatitis C virus research
- Viral Infections and Outbreaks Research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Insect Pest Control Strategies
- Research on Leishmaniasis Studies
- Zoonotic diseases and public health
Malaria Consortium
2021-2025
University of Oxford
2018-2023
Mahidol University
2016-2018
Economic & Social Sciences, Health Systems & Medical Informatics
2018
Mahidol Oxford Tropical Medicine Research Unit
2016-2018
Shoklo Malaria Research Unit
2016-2018
Inserm
2018
University of California, Irvine
2018
BackgroundPotentially untreatable Plasmodium falciparum malaria threatens the Greater Mekong subregion. A previous series of pilot projects in Myanmar, Laos, Cambodia, and Vietnam suggested that mass drug administration was safe, when added to provision early diagnosis treatment, could reduce reservoir P interrupts transmission. We examined effects a scaled-up programme this strategy four townships eastern Myanmar on incidence malaria.MethodsThe implemented Myawaddy, Kawkareik, Hlaingbwe,...
Abstract Background Until recently, due to widespread prevalence of molecular markers associated with sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ) resistance in east southern Africa, seasonal malaria chemoprevention (SMC) has not been used at scale this region. This study assessed the protective effectiveness monthly administration SP + AQ (SPAQ) children aged 3–59 months Karamoja sub-region, Uganda, where parasite is assumed be high transmission seasonal. Methods A two-arm...
Abstract Background Seasonal malaria chemoprevention (SMC) is an effective intervention to prevent in children locations where the burden of high and transmission seasonal. There growing evidence suggesting that SMC with sulfadoxine–pyrimethamine amodiaquine can retain its level effectiveness East Southern Africa despite resistance concerns. This study aims generate on when delivered under programmatic conditions area unknown anti-malarial drug profile Northern Bahr el-Ghazal region South...
Abstract Background Seasonal malaria chemoprevention (SMC) is a highly effective intervention for prevention in high burden areas with seasonal transmission, historically implemented the Sahel. Mozambique contributes to 4% of global cases. Malaria Consortium, partnership National Control Programme, conducted two-year phased SMC study Nampula province using sulfadoxine-pyrimethamine (SP) plus amodiaquine (AQ), or SPAQ, children under five. Phase one results presented here highlight...
Artemisinin resistance, linked to polymorphisms in the Kelch gene on chromosome 13 of Plasmodium falciparum (k13), has outpaced containment efforts South East Asia. For national malaria control programmes region, it is important establish a surveillance system which includes monitoring for k13 associated with clinical phenotype. Between February and December 2013, parasite clearance was assessed 35 patients uncomplicated P. treated artesunate monotherapy followed by 3-day ACT an isolated...
Introduction Genomic data constitute a valuable adjunct to routine surveillance that can guide programmatic decisions reduce the burden of infectious diseases. However, genomic capacities remain low in Africa. This study aims operationalise functional malaria molecular system Mozambique for guiding control and elimination. Methods analyses prospective seeks generate Plasmodium falciparum genetic (1) monitor markers drug resistance deletions rapid diagnostic test targets; (2) characterise...
Seasonal malaria chemoprevention (SMC) is a highly effective community-based intervention to prevent infections in areas where the burden high and transmission occurs mainly during rainy season. In Africa, so far, SMC has been implemented Sahel region. Mozambique contributes 4% of global cases, responsible for one-quarter all deaths country. Based on recommendations Malaria Strategic Plan, Consortium, partnership with National Control Programme Mozambique, initiated phased implementation...
Background Malaria is a significant cause of morbidity and mortality in children aged under 5 years Mozambique. The World Health Organization recommends seasonal malaria chemoprevention (SMC), the administration four monthly courses sulfadoxine-pyrimethamine (SP) amodiaquine (AQ), to 3-59 months during rainy season. However, as resistance SP widespread East Southern Africa, SMC has so far only been implemented across Sahel West Africa. Objective This protocol describes first phase pilot...
The World Health Organization (WHO) recommends seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine and amodiaquine (SPAQ) for children aged 3 to 59 months, living in areas where transmission is highly seasonal. However, due widespread prevalence of resistance markers, SMC has not been implemented at scale East Southern Africa. An initial study Uganda showed that SPAQ was feasible, acceptable, protective against eligible Karamoja region. Nonetheless, exploration alternative...
ABSTRACT The efficacy and effectiveness of antimalarial drugs are threatened by increasing levels resistance therefore require continuous monitoring. Chemoprevention is increasingly deployed as a malaria control measure, but there no generally accepted methods assessment. We propose simple method grading the parasitological response to chemoprevention (focusing on seasonal chemoprevention) that based pharmacometric
Abstract Introduction Seasonal malaria chemoprevention (SMC) is a highly effective intervention for prevention in high burden areas with seasonal transmission, historically implemented the Sahel. Mozambique contributes to 4% of global cases, being one four major causes mortality nationally. The mid-term review Malaria Strategic Plan 2017–2022 recommended SMC Mozambique. Consortium, partnership National Control Program, conducted two-year phased study Nampula province using...
<sec> <title>BACKGROUND</title> Malaria is a significant cause of morbidity and mortality in children aged under 5 years Mozambique. The World Health Organization recommends seasonal malaria chemoprevention (SMC), the administration four monthly courses sulfadoxine-pyrimethamine (SP) amodiaquine (AQ), to 3-59 months during rainy season. However, as resistance SP widespread East Southern Africa, SMC has so far only been implemented across Sahel West Africa. </sec> <title>OBJECTIVE</title>...
<ns4:p><ns4:bold>Background</ns4:bold>: The World Health Organization (WHO) recommends seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine and amodiaquine for children aged 3 to 59 months, living in areas where transmission is highly seasonal. However, due widespread prevalence of resistance markers, SMC has not been implemented at scale East Southern Africa. An initial study Uganda showed that SPAQ was feasible, acceptable, protective against eligible Karamoja region....
Abstract Background Seasonal malaria chemoprevention (SMC) is an effective intervention to prevent in children locations where the burden of high and transmission seasonal. There growing evidence suggesting that SMC with sulfadoxine-pyrimethamine amodiaquine can retain its level effectiveness East Southern Africa despite resistance concerns. This study aims generate on when delivered under programmatic conditions area unknown antimalarial drug profile Northern Bahr el-Ghazal region South...
<sec> <title>BACKGROUND</title> Seasonal malaria chemoprevention (SMC) is a highly effective community-based intervention to prevent infections caused by Plasmodium falciparum in areas where the burden of high and transmission seasonal. SMC commonly seen as success story Sahel region, however, there are regions east southern Africa seasonal, high. The same decision-making frameworks that were used unlikely be applicable due higher pre-existing resistance drugs used, seasonality...
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<sec> <title>BACKGROUND</title> Seasonal malaria chemoprevention (SMC) is a highly effective community-based intervention to prevent infections in areas where the burden high and transmission occurs mainly during rainy season. In Africa, so far, SMC has been implemented Sahel region. Mozambique contributes 4% of global cases, represents one out first four causes death country. Based on recommendations Malaria Strategic Plan, Consortium, partnership with Mozambican National Control Program...
Abstract Background : Until recently, due to widespread prevalence of molecular markers associated with sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ) resistance in east southern Africa, seasonal malaria chemoprevention (SMC) has not been used at scale this region. This study assessed the protective effectiveness monthly administration SP+ AQ (SPAQ) children aged 3–59 months Karamoja sub-region, Uganda, where parasite is assumed be high transmission seasonal. Methods: A two-arm...