A5037065375- Malaria Research and Control
- Mosquito-borne diseases and control
- Global Maternal and Child Health
- Viral Infections and Outbreaks Research
- Vaccine Coverage and Hesitancy
- Computational Drug Discovery Methods
- Diverse Scientific Research Studies
- Insect Pest Control Strategies
- Artificial Intelligence in Healthcare and Education
- Parasites and Host Interactions
- COVID-19 diagnosis using AI
- Community Health and Development
- COVID-19 Clinical Research Studies
- Emergency and Acute Care Studies
- Respiratory viral infections research
- Data-Driven Disease Surveillance
- Child and Adolescent Health
- Travel-related health issues
- Child Nutrition and Water Access
- COVID-19 epidemiological studies
- Viral Infections and Vectors
- Mobile Health and mHealth Applications
Malaria Consortium
2015-2025
Malaria Consortium
2018
Abstract Background Until recently, due to widespread prevalence of molecular markers associated with sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ) resistance in east southern Africa, seasonal malaria chemoprevention (SMC) has not been used at scale this region. This study assessed the protective effectiveness monthly administration SP + AQ (SPAQ) children aged 3–59 months Karamoja sub-region, Uganda, where parasite is assumed be high transmission seasonal. Methods A two-arm...
BackgroundThe potential effects of SARS-CoV-2 and Plasmodium falciparum co-infection on host susceptibility pathogenesis remain unknown. We aimed to establish the prevalence malaria describe clinical characteristics P in a high-burden setting.MethodsThis was an exploratory prospective, cohort study patients with COVID-19 who were admitted hospital Uganda. Patients all ages PCR-confirmed diagnosis infection had provided informed consent or assent consecutively enrolled from treatment centres...
Pyrethroid resistance in African vector mosquitoes is a threat to malaria control. Resistant can survive insecticide doses that would normally be lethal. We studied effects of such on Plasmodium falciparum development inside kdr-resistant Anopheles gambiae s.s. Uganda.We collected An. homozygous for kdr-L1014S mutation, fed them blood samples from 42 P. falciparum-infected local patients, then exposed either nets treated with sub-lethal deltamethrin or untreated nets. After seven days, we...
Abstract Background Scale-up of malaria interventions seems to have contributed a decline in the disease but other factors may also had some role. Understanding changes transmission and determinant will help adapt control strategies accordingly. Methods Four sites Ethiopia Uganda were set up monitor epidemiological effectiveness over time. Here, results survey during peak season 2012 are reported, which be used as baseline for subsequent surveys support adaptation strategies. Data on...
The large-scale introduction of malaria rapid diagnostic tests (RDTs) promises to improve management fever patients and the rational use valuable anti-malarials. However, evidence on impact RDT overprescription anti-malarials has been mixed. This study explored determinants provider decision-making prescribe following a negative result. A qualitative was conducted in rural district mid-western Uganda 2011, ten months after introduction. Prescriptions for all with results were first audited...
The distribution of long-lasting insecticidal nets (LLINs) through universal coverage campaigns is a widely adopted approach for the prevention malaria at scale. While post-distribution surveys play valuable role in determining cross-sectional levels LLIN retention and use, as well frequently cited reasons non-use, few studies have explored consistency use over time, within expected lifespan net, factors which may drive this. In this qualitative study, 74 in-depth interviews were conducted...
Across the developing world, countries are increasingly adopting integrated community case management of childhood illnesses (iCCM) strategy in efforts to reduce child mortality. This intervention's effectiveness is dependent on adoption and changes care-seeking practices. We assessed implementation process a theory-driven dialogue (CD) intervention specifically designed strengthen support uptake newly introduced iCCM services related behaviours three African countries. A qualitative...
Successful pre-referral treatment with rectal artesunate (RA) for suspected severe malaria requires operational linkages between community health workers (CHWs) and referral facilities, acceptance of adherence to practices by CHWs caregivers. This qualitative study investigated how understanding the concept 'pre-referral treatment' is used in related decision-making following provision RA Uganda. Narrative interviews were conducted 30 caregivers children under five who received within...
A universal coverage campaign (UCC) with long-lasting insecticidal nets (LLINs) was implemented in four districts Midwestern Uganda 2009–2010. Entomological surveys were carried out to monitor changes vector density, behaviour and malaria transmission following this intervention. Anopheles mosquitoes collected using CDC light traps quarterly human landing catch twice a year sites. Collections done at baseline before the over three-year period campaign. Plasmodium falciparum circumsporozoite...
Successful scale-up in the use of malaria rapid diagnostic tests (RDTs) requires that patients accept testing and treatment based on RDT results healthcare providers treat according to test results. Patient-provider communication is a key component quality care, leads improved patient satisfaction, higher adherence better health outcomes. Voiced or perceived expectations are also known influence decision-making among providers. While there has been growth literature provider practices around...
The World Health Organization (WHO) recommends seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine and amodiaquine (SPAQ) for children aged 3 to 59 months, living in areas where transmission is highly seasonal. However, due widespread prevalence of resistance markers, SMC has not been implemented at scale East Southern Africa. An initial study Uganda showed that SPAQ was feasible, acceptable, protective against eligible Karamoja region. Nonetheless, exploration alternative...
Malaria remains the number one cause of morbidity and mortality in Uganda. In 2009, United States President's Initiative (PMI) funded an indoor residual spraying (IRS) project 10 mid-northern districts, resulting marked reductions malaria prevalence over 5 years, from 62.5 percent to 7.2 percent. When ended IRS withdrawn, increased exponentially pre-IRS level 63 2016 was characterized by frequent life-threatening upsurges that were exacerbated a weak national led surveillance system with...
Background: Our understanding of the potential impact SARS-CoV-2 and malaria co-infection on host susceptibility pathogenesis remains unclear. We determined prevalence describe consequences in a high burden setting.Methods: This was prospective cohort study hospitalized Covid-19 patients Uganda. Malaria diagnosis done using rapid diagnostic tests, microcopy molecular methods. Previous P. falciparum exposure assessed serologic responses to panel antigens multiplex bead assay. Additional...
Abstract Background Malaria remains the number one cause of morbidity and mortality in Uganda. In 2009, United States’ President’s Initiative (PMI) funded an indoor residual spraying (IRS) project 10 Mid- northern districts, resulting marked reductions malaria prevalence over five years, from 62.5 percent to 7.2 percent. When was completed IRS subsequently withdrawn, increased dramatically pre-IRS level 63 2016 characterised by frequent life-threatening upsurges that were exasperated a weak...
Background: As COVID-19 disease surges across much of the world, researchers in different settings have a unique opportunity to address various research priorities that been identified. The challenges containment and mitigation strategies present for research, especially resource limited settings, could be significant negatively impact essential contribution these research.
 Objectives: To describe experiences conducting during this pandemic, discuss faced implemented challenges
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<ns4:p><ns4:bold>Background</ns4:bold>: The World Health Organization (WHO) recommends seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine and amodiaquine for children aged 3 to 59 months, living in areas where transmission is highly seasonal. However, due widespread prevalence of resistance markers, SMC has not been implemented at scale East Southern Africa. An initial study Uganda showed that SPAQ was feasible, acceptable, protective against eligible Karamoja region....
Timely recognition and referral of severely ill children is especially critical in low-resource health systems. Pulse-oximeters can improve outcomes by detecting hypoxaemia, a severity indicator the most common causes death children. Cost-effectiveness pulse-oximeters has been proven low-income settings. However, evidence on their usability community settings scarce.This study explores for primary care workers Cambodia, Ethiopia, South Sudan, Uganda. We collected observational data, through...
Abstract Background Malaria remains the number one cause of morbidity and mortality in Uganda. In 2009, an indoor residual spraying (IRS) programme was implemented 10 Northern districts, resulting marked reductions malaria burden, a prevalence just 7 percent. IRS withdrawn after five years among children subsequently increased dramatically from 2014-2016. This upsurge led to focus on training district staff surveillance, epidemic preparedness, response. An increase cases detected again 2018...