A5051536655- Global Maternal and Child Health
- Child Nutrition and Water Access
- Respiratory viral infections research
- Neonatal Respiratory Health Research
- COVID-19 epidemiological studies
- Pneumonia and Respiratory Infections
- Emergency and Acute Care Studies
- Vaccine Coverage and Hesitancy
- Global Public Health Policies and Epidemiology
- Heavy Metal Exposure and Toxicity
- Neonatal and fetal brain pathology
- Child and Adolescent Health
- Vibrio bacteria research studies
- Healthcare Systems and Reforms
- HIV/AIDS Research and Interventions
- Climate Change and Health Impacts
- HIV/AIDS Impact and Responses
- Viral Infections and Outbreaks Research
- COVID-19 and healthcare impacts
- HIV, Drug Use, Sexual Risk
- SARS-CoV-2 detection and testing
- Air Quality and Health Impacts
- COVID-19 Clinical Research Studies
- Trace Elements in Health
- Bacterial Infections and Vaccines
Sachs' Children and Youth Hospital
2016-2025
Karolinska Institutet
2016-2025
Uppsala University
2024
Stockholm South General Hospital
2011-2023
Makerere University
2020-2023
Lund University
2023
University of Gothenburg
2023
Karolinska University Hospital
2023
Gates Foundation
2022
University of Ibadan
2022
OBJECTIVES To study the dose-response relation between cadmium dose and renal tubular damage in a population of workers people environmentally or occupationally exposed to low concentrations cadmium. METHODS Early kidney 1021 people, cadmium, was assessed from urine estimate dose, protein HC (α 1 -microglobulin) assess proteinuria. RESULTS There an age sex adjusted correlation urinary HC. The prevalence proteinuria ranged 5% among unexposed 50% most group. corresponding odds ratio 6.0 (95%...
The prevalence of allergic diseases has increased rapidly in recent decades, particularly children. For adequate prevention it is important not only to identify risk factors, but also possible protective factors. aim this study was compare the and sensitization between farm children, children anthroposophic families, reference with factors that may protect against disease.The cross-sectional design included 14,893 aged 5-13 years, from families (recruited Steiner schools) Austria, Germany,...
Abstract Osteoporosis is a major cause of morbidity worldwide. A number risk factors, such as age and gender, are well established. High cadmium exposure causes renal damage in severe cases also osteoporosis osteomalacia. We have examined whether long-term low-level increases the osteoporosis. Bone mineral density (BMD) forearm was measured 520 men 544 women, aged 16–81 years, environmentally or occupationally exposed to cadmium, using dual-energy X-ray absorptiometry (DXA) technique....
The aim was to assess how urinary creatinine is affected by age, gender, body size and meat intake, determine what extent such factors might affect the adjustment of cadmium. study based on three Swedish studies: (1) 67 non-smoking women aged 20–50 years (24-h urine samples); (2) 289 men 434 16–81 (spot (3) 98 105 19–72 samples). effects surface area (as an indicator muscle mass), intake cadmium were analysed using multiple regression analyses. Gender- age-related variations in adjusted for...
Summary Background Information about acute reactions to foods among children is limited. Objective To describe the overall incidence of anaphylaxis in a paediatric emergency department ( ED ) setting and relation sex age, clinical characteristics management. Methods In review medical records, with visits at any three hospitals S tockholm C ounty during 2007 were targeted. Inclusion criteria adverse reaction or anaphylaxis. Results 383 fulfilled inclusion which 371 had foods. The was 32 per...
Curative interventions delivered by community health workers (CHWs) were introduced to increase access services for children less than five years and have previously targeted single illnesses. However, CHWs in the integrated case management of childhood illnesses strategy adopted Uganda 2010 will manage multiple There is little documentation about performance This study compared managing malaria pneumonia with alone eastern factors influencing performance. A mixed methods was conducted among...
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Although severe acute COVID-19 is rare in children, SARS-CoV-2 infection can trigger the novel post-infectious condition multisystem inflammatory syndrome children (MIS-C). Increased knowledge on risk factors for MIS-C could improve our understanding of pathogenesis and better guide targeted public health interventions. The aim study was to assess with identify vulnerable children.A register-based cohort including all adolescents <19 years born Sweden between March 1, 2001- December 31, 2020...
Abstract Antiretroviral therapy (ART) started to become more widely available in Vietnam 2005. However, up now, very little is known about factors influencing ART adherence among people living with HIV (PLHIV) Vietnam. This qualitative study aimed describe PLHIV a northern province Vietnam, and explore possibilities of home delivery ART. Forty-eight participants (36 men 12 women), including patients on their relatives, were divided seven focus group discussions. The topics discussed...
To evaluate the carriage prevalence, serotype distribution, and antibiotic resistance for pneumococcal isolates collected 4–8 years after introduction of conjugate vaccines (PCVs) in Stockholm, Sweden, to identify risk factors calculate invasive disease potential emerging serotypes. Nasopharyngeal aspirates were from 3024 children aged 0–<5 at regular visits 23 Child Health Centers Stockholm County 2011–2015, 787 parents 2014–2015. The was calculated serotypes using 824 patients all ages...
Face-mask ventilation is the most common resuscitation method for birth asphyxia. Ventilation with a cuffless laryngeal mask airway (LMA) has potential advantages over face-mask during neonatal in low-income countries, but whether use of an LMA reduces mortality and morbidity among neonates asphyxia unknown.In this phase 3, open-label, superiority trial Uganda, we randomly assigned who required positive-pressure to be treated by midwife or ventilation. All had estimated gestational age at...
Abstract Background There is a controversy over the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in an era less virulent variants and increasing population immunity. We compared outcomes adults attending emergency department (ED) with Omicron, influenza, or syncytial virus (RSV) infection. Methods Retrospective multicenter cohort study including ED 6 care hospitals Stockholm County, Sweden, RSV infection during 2021–2022 2015–2019. During 2021–2022,...
Long-term exposure to cadmium may cause kidney and bone damage. Urinary is commonly used as the dose estimate for body burden of cadmium. However, elevated levels in urine reflect not only high but also renal dysfunction. In this study we blood estimate. addition, analyzed lead. We examined 479 men 542 women, ages 16-81 years, who were environmentally or occupationally exposed urinary protein alpha 1-microglobulin a marker tubular proteinuria measured forearm mineral density using...
The primary study aim was to examine the possible role of cadmium as a risk factor for osteoporosis by determining bone mineral density (BMD) in workers previously exposed cadmium. A second objective validate BMD data obtained with movable instrument.43 who were < or = 5 years before 1978 studied. Cadmium blood (B-Cd) and urine (U-Cd) used dose estimates. assessed forearm, spine, hip (neck trochanter) dual energy x ray absorptiometry (DXA) instrument. Age sex matched reference populations...
Abstract The aim of this study was to analyze the relationship between low-level cadmium exposure and distal forearm fractures. Altogether, 1021 men women exposed in Sweden were included. indicates that is associated with increased risk fractures people over age 50. Introduction: Very few studies have been performed on environmental factors for Cadmium known cause damage kidneys high doses bone. Materials Methods: A total 479 542 women, 16-81 years age, environmentally or occupationally...
Streptococcus pneumoniae is a major cause of pneumonia and sinusitis. Pneumonia kills >1 million children annually, sinusitis potentially serious pediatric disease that increases the risk orbital intracranial complications. Although pneumococcal conjugate vaccine (PCV) effective against invasive disease, its effectiveness less consistent, effect on not known. We compared hospitalization rates due to sinusitis, pneumonia, empyema before after sequential introduction PCV7 PCV13.All 0 <18 years...
Efforts to improve access treatment for common illnesses in children less than five years initially targeted malaria alone under the home management of strategy. However this strategy, with other were often wrongly treated anti-malarials. Integrated community case childhood is now recommended but its effect on promptness appropriate pneumonia unclear. To determine integrated and receiving prompt antibiotics symptoms outcomes as well associated factors. A follow-up study was nested within a...
Graphical abstractAbstractBackgroundChildhood exposure to a farm environment has been shown protect against the development of inflammatory diseases, such as allergy, asthma, and bowel disease.ObjectiveWe sought investigate whether both microbes structures nonmicrobial origin, sialic acid N-glycolylneuraminic (Neu5Gc), might play significant role.MethodsExposure Neu5Gc was evaluated by quantifying anti-Neu5Gc antibody levels in sera children enrolled 2 studies: Prevention Allergy Risk...
According to the United Nations Educational, Science and Cultural Organization, 194 countries had implemented country-wide school closures by April 1, 2020, in an effort combat COVID-19 pandemic. It is estimated that those affected 91.3% of students across globe. However, Sweden adopted a different approach strict lockdowns imposed elsewhere day-care centres schools for children up 15 years age remained open. The strategic decision shift distance learning only aged 16 older was influenced...
Background During the initial phase of Coronavirus Disease 2019 (COVID-19) pandemic, reduced numbers acutely ill or injured children presented to emergency departments (EDs). Concerns were raised about potential for delayed and more severe presentations an increase in diagnoses such as diabetic ketoacidosis mental health issues. This multinational observational study aimed number presenting EDs across Europe during early COVID-19 pandemic factors influencing this investigate changes severity...
Nigeria reported an upsurge in cholera cases October 2020, which then transitioned into a large, disseminated epidemic for most of 2021. This study aimed to describe the epidemiology, diagnostic performance rapid test (RDT) kits and factors associated with mortality during epidemic.A retrospective analysis national surveillance data.33 37 states (including Federal Capital Territory) Nigeria.Persons who met case definition (a person any age acute watery diarrhoea, or without vomiting) between...