A5026974675- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Dermatology and Skin Diseases
- Pediatric health and respiratory diseases
- Stress Responses and Cortisol
- Infant Health and Development
- Neonatal Respiratory Health Research
- Gut microbiota and health
- Eosinophilic Esophagitis
- Epigenetics and DNA Methylation
- Air Quality and Health Impacts
- Gastrointestinal motility and disorders
- Pregnancy and Medication Impact
- Birth, Development, and Health
- Social and Educational Sciences
- Gastroesophageal reflux and treatments
- Reproductive System and Pregnancy
- Probiotics and Fermented Foods
- School Health and Nursing Education
- Neuroendocrine regulation and behavior
- Intestinal and Peritoneal Adhesions
- Preterm Birth and Chorioamnionitis
- Immune Cell Function and Interaction
- Occupational exposure and asthma
Karolinska Institutet
2012-2022
Stockholm South General Hospital
2013-2022
Sachs' Children and Youth Hospital
2013-2022
University of Zurich
2017
CK-CARE
2017
Human Factors (Norway)
2017
Boston Children's Hospital
2007-2012
Instituto de Saúde
2010
Abstract Background Breast‐feeding has many beneficial effects on the developing immune system of newborn. Breast milk contains immunoregulatory factors, such as nano‐sized vesicles named exosomes. This study aimed at characterizing breast exosomes from human early and mature to investigate whether allergic sensitization an anthroposophic lifestyle could influence exosome profile. Methods was collected 22 mothers day 3–8 61 2 months postpartum, all part ALADDIN birth cohort. Isolated were...
An anthroposophic lifestyle, which has been associated with reduced allergy risk in children, several characteristics that could influence gut microbiota. This study aimed to investigate the impact of lifestyle as well specific early life exposures on In total, 665 stool samples from 128 mother-infant pairs ALADDIN birth cohort were included. Samples collected infants at ages 6 days, 3 weeks, 2 months and months, their mothers before after delivery, respectively, analyzed using...
In this population-based study, 90 children from three European countries were examined to determine the impact of lifestyle on fecal microbiota. The study was designed assess two extreme lifestyles that we hypothesized could microbial composition in gut: i.e., an anthroposophic (restricted use antibiotics, greater consumption fermented vegetables, etc.) versus living a farm (greater milk, contact with animals, etc.). previous studies, these correlated lower prevalence allergies. Terminal...
Background: Growing up on a farm and an anthroposophic lifestyle are associated with lower prevalence of allergic diseases in childhood. It has been suggested that the enhanced exposure to endotoxin is important protective factor environments. Little known about other microbial components farms families. Objective: To assess levels determinants bacterial endotoxin, mould β (1,3)‐glucans fungal extracellular polysaccharides (EPS) house dust children, Steiner school children reference...
The intestinal flora is considered to have an impact on the development of immune system. In anthroposophic lifestyle, a diet comprising vegetables spontaneously fermented by lactobacilli, and restrictive use antibiotics, anti‐pyretics vaccinations, typical. aim this study was assess gut in infants relation certain lifestyle characteristics associated with anthroposophy. Sixty‐nine children < 2 years age 59 similar traditional were clinically examined questionnaire replies assessed. Fecal...
To cite this article: Stenius F, Swartz J, Lilja G, Borres M, Bottai Pershagen Scheynius A, Alm J. Lifestyle factors and sensitization in children – the ALADDIN birth cohort. Allergy 2011; 66: 1330–1338. Background: Several cross-sectional studies indicate that an anthroposophic lifestyle reduces risk of allergy children. We initiated Assessment Allergic Disease During Infancy (ALADDIN) cohort to elucidate role specific supposed mediate effect. The aims study are describe report patterns...
BackgroundAnalysis of allergen-specific IgE responses in birth cohorts with microarrayed allergens has provided detailed information regarding the evolution specific children. High-resolution data early development IgG are needed.ObjectiveWe sought to analyze reactivity mothers during pregnancy, cord blood samples, breast milk, and infants first years life aim investigate whether maternal can protect against sensitization offspring.MethodsPlasma samples from third trimester, blood, milk...
Maternal diet modifies epigenetic programming in offspring, a potentially critical factor the immune dysregulation of modern societies. We previously found that prenatal fish oil supplementation affects neonatal T-cell histone acetylation genes implicated adaptive immunity including PRKCZ, IL13, and TBX21. In this study, we measured H3 H4 levels by chromatin immunoprecipitation 173 term placentas collected prospective birth cohort, ALADDIN, which information on lifestyle is thoroughly...
Graphical abstractAbstractBackgroundChildhood exposure to a farm environment has been shown protect against the development of inflammatory diseases, such as allergy, asthma, and bowel disease.ObjectiveWe sought investigate whether both microbes structures nonmicrobial origin, sialic acid N-glycolylneuraminic (Neu5Gc), might play significant role.MethodsExposure Neu5Gc was evaluated by quantifying anti-Neu5Gc antibody levels in sera children enrolled 2 studies: Prevention Allergy Risk...
OBJECTIVE. Our aim was to investigate the role of measles vaccination and infection in development allergic disease atopic sensitization. METHODS. A total 14 893 children were included from cross-sectional, multicenter Prevention Allergy–Risk Factors for Sensitization Children Related Farming Anthroposophic Lifestyle study, conducted 5 European countries (Austria, Germany, Netherlands, Sweden, Switzerland). The between 13 years age represented farm children, Steiner-school 2 reference...
Abstract Background Epigenetic regulation has been suggested to be a link between environmental intrauterine exposures and development of asthma allergy. The placenta is an essential part the environment. We have previously found innate immune receptor CD14 differentially expressed on mRNA level in placentas relation lifestyle parental allergen sensitization. here hypothesized that promoter region may subject differential DNA methylation therefore exposure expression. Methods Ninety‐four...
Abstract Background The etiology of recurrent abdominal pain functional origin ( AP ) is largely unknown. Antibiotic treatment influences the intestinal microbiota, and a few studies have indicated an increased risk in adults after antibiotic treatment. Corresponding data children are lacking. aim this study was to explore association between during childhood at 12 years. Methods Two thousand seven hundred thirty‐two from S wedish, population‐based birth cohort. Parents reported use for 2 9...
DNA methylation changes may predispose becoming IgE-sensitized to allergens. We analyzed whether in peripheral blood mononuclear cells (PBMC) is associated with IgE sensitization at 5 years of age (5Y). was measured 288 PBMC samples from 74 mother/child pairs the birth cohort ALADDIN (Assessment Lifestyle and Allergic Disease During INfancy) using HumanMethylation450BeadChip (Illumina). PBMCs were obtained mothers during pregnancy their children cord blood, 2 5Y. levels each time point...
To the Editor: Data from experimental animal models have previously shown that allergen-specific IgG antibodies are transmitted mother to offspring via breast milk1,2 and provided evidence protect specifically against allergic sensitization.2 In some studies, it has been demonstrated for humans breast-feeding a prophylactic effect atopic disease but there also reports arguing this underlying mechanisms not known.3 There is bacterial antigens (ie, pneumococcal antigens) transferred blood...
Prenatal environmental exposures are considered to contribute the development of allergic sensitization by epigenetic mechanisms. The role histone acetylation in placenta has not been examined yet. We hypothesized that placental at promoter regions allergy-related immune regulatory genes is associated with allergens child. Histones H3 and H4 6 selected was assessed a chromatin immunoprecipitation assay 173 term placentas collected prospective birth-cohort ALADDIN. IgE children followed from...
Abstract Background Changes in immune cell composition during the immunological window within first years after birth are not fully understood, especially effect that different lifestyles might have on functionality. Methods Peripheral blood mononuclear cells from mothers and their children at two anvd five were analyzed by mass cytometry. Immune functionality was according to family lifestyle (anthroposophic non‐anthroposophic). Results We found no significant differences proportions of...
Abstract Background The effects of proton-pump inhibitors (PPIs) on the infant microbiome remain unclear. Swedish pilot cohort study to assess longitudinal effect long-term PPI gut microbiome, including ten newborn infants operated for esophageal atresia exposed PPIs (mean 57 weeks), compared healthy one-year-old controls. All children were born vaginally and otherwise healthy. Within- between sample diversity fecal was assessed using untargeted whole genome Shotgun metagenomics which...