A5078130322- Asthma and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Mast cells and histamine
- Immune Cell Function and Interaction
- Blood Coagulation and Thrombosis Mechanisms
- Urticaria and Related Conditions
- Lipoproteins and Cardiovascular Health
- Allergic Rhinitis and Sensitization
- Venous Thromboembolism Diagnosis and Management
- Epigenetics and DNA Methylation
- Food Allergy and Anaphylaxis Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Neonatal Respiratory Health Research
- Cardiac Valve Diseases and Treatments
- T-cell and B-cell Immunology
- Extracellular vesicles in disease
- Dermatology and Skin Diseases
- Pediatric health and respiratory diseases
- Respiratory viral infections research
- MicroRNA in disease regulation
- Eosinophilic Esophagitis
- Immunodeficiency and Autoimmune Disorders
- RNA and protein synthesis mechanisms
- Inhalation and Respiratory Drug Delivery
- Atherosclerosis and Cardiovascular Diseases
Philipps University of Marburg
2016-2025
Universities of Giessen and Marburg Lung Center
2018-2024
German Center for Lung Research
2017-2024
Technische Hochschule Mittelhessen
2022-2024
Justus-Liebig-Universität Gießen
2023-2024
Research Network (United States)
2019-2022
John Paul II Hospital
2011-2020
Authorised Association Consortium
2018
Worldwide Universities Network
2017
GTx (United States)
2016
Regulatory T cells (Tregs) control immune system activity and inhibit inflammation. While, in mice, short-chain fatty acids (SCFAs) are known to be essential regulators of naturally occurring vitro induced Tregs (iTregs), data on their contribution the development human iTregs sparse, with no reports successful SCFAs-augmented generation fully functional iTregs. Likewise, markers undoubtedly defining missing. Here, we aimed generate using protocols involving SCFAs characterize underlying...
Abstract Rationale and Objective Plasma extracellular vesicles (EVs) represent a vital source of molecular information about health disease states. Due to their heterogenous cellular sources, EVs cargo may predict specific pathomechanisms behind phenotypes. Here we aimed utilize EV microRNA (miRNA) signatures gain new insights into underlying mechanisms obesity‐associated low type‐2 asthma. Methods Obese asthma (OA) non‐obese (NOA) patients were selected from an cohort conjointly with...
Epigenetic modifications are known to mediate both beneficial and unfavorable effects of environmental exposures on the development clinical course asthma. On molecular level, epigenetic mechanisms participate in multiple aspects emerging ongoing asthma pathology.
While immunodeficiency of immaturity the neonate has been considered important as basis for unusual susceptibility to infection, it also recognized that ability progress from an immature Th2 cytokine predominance a Th1 profile relevance in determining whether children will develop allergy, providing opportunity epigenetic regulation through environmental pressures. However, this notion remains relatively unexplored. Here, we present evidence there are two major control points explain cord...
Maternal diet modifies epigenetic programming in offspring, a potentially critical factor the immune dysregulation of modern societies. We previously found that prenatal fish oil supplementation affects neonatal T-cell histone acetylation genes implicated adaptive immunity including PRKCZ, IL13, and TBX21. In this study, we measured H3 H4 levels by chromatin immunoprecipitation 173 term placentas collected prospective birth cohort, ALADDIN, which information on lifestyle is thoroughly...
Idiopathic inflammatory myopathies (IIM) are characterized by chronic inflammation, endothelial dysfunction, and muscle tissue mitochondrial defect, leading to the local oxidative stress response. However, data on its systemic intensity correlation with IIM clinical laboratory characteristics remains scarce. In clinically stable dermatomyositis (n = 18) myositis 38) patients matched controls 50), we measured global response in peripheral blood using a novel coumarin boronic acid (CBA) assay...
Epidemiological studies identified raw cow's milk consumption as an important environmental exposure that prevents allergic diseases. In the present study, we investigated whether has capacity to induce tolerance unrelated, non-milk, food allergen. Histone acetylation of T cell genes was assess potential epigenetic regulation. Female C3H/HeOuJ mice were sensitized and challenged ovalbumin. Prior sensitization, treated with milk, processed or phosphate-buffered saline for eight days. Allergic...
Toll-like receptor 2 gene (TLR2) –16934A>T polymorphism has been shown to be associated with severity of atopic dermatitis (AD) as measured using scoring (SCORAD) index. Moreover, TLR2–16934A>T atopy and allergic disorders in farmers’ children.The aim this study was evaluate an association between AD phenotype, including disease concomitant diseases, or potential serum markers also find a molecular background the clinical associations.Genotyping for performed 130 consecutive adult ambulatory...
Genomewide association studies identified ORMDL3 as a plausible asthma candidate gene. ORMDL proteins regulate sphingolipid metabolism and ceramide homeostasis participate in lymphocyte activation eosinophil recruitment. Strong sequence homology between the three genes protein conservation among different species suggest that they may have shared functions. We hypothesized if single nucleotide polymorphisms (SNPs) alter its gene expression play role asthma, variants ORMDL1 ORMDL2 might also...