A5072678137- Chronic Obstructive Pulmonary Disease (COPD) Research
- Protease and Inhibitor Mechanisms
- Asthma and respiratory diseases
- Peptidase Inhibition and Analysis
- Respiratory Support and Mechanisms
- Respiratory and Cough-Related Research
- Pulmonary Hypertension Research and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Pediatric health and respiratory diseases
- Advanced Chemical Sensor Technologies
- Extracellular vesicles in disease
- Inhalation and Respiratory Drug Delivery
- Neonatal Respiratory Health Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Effects of Vibration on Health
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Insect Resistance and Genetics
- Obstructive Sleep Apnea Research
- Cardiovascular and exercise physiology
- Delphi Technique in Research
- MicroRNA in disease regulation
- Cardiac Fibrosis and Remodeling
- S100 Proteins and Annexins
- Nutrition, Genetics, and Disease
- Health and Medical Studies
Philipps University of Marburg
2013-2024
Universities of Giessen and Marburg Lung Center
2016-2024
German Center for Lung Research
2015-2024
Universitätsklinikum Gießen und Marburg
2014-2024
National and Kapodistrian University of Athens
2023
University Medical Center
2015-2020
Philips (United Kingdom)
2020
Praxis
2020
Phillips University
2017
Pulmonary Associates
2016
Zusammenfassung Die vorliegende Leitlinie ist eine Neufassung und Aktualisierung der zur Diagnostik Therapie von Patienten mit Asthma, welche die bisher für den deutschen Sprachraum gültige Version aus dem Jahr 2006 ablöst. Fülle an neuen Erkenntnissen Pathophysiologie zu Phänotypen Asthma das erweiterte Spektrum diagnostischen therapeutischen Möglichkeiten bei dieser Erkrankung machte notwendig. Es werden sowohl Kinder Jugendliche als auch Erwachsene aktuellen, Evidenz-basierten...
Chronic obstructive pulmonary disease (COPD) is a progressive, inflammatory lung that affects large number of patients and has significant impact. One hallmark the presence bacteria in lower airways.The aim this study was to analyze detailed structure microbial communities found lungs healthy individuals with COPD. Nine COPD as compared 9 underwent flexible bronchoscopy BAL performed. Bacterial nucleic acids were subjected terminal restriction fragment (TRF) length polymorphism clone library...
Chronic obstructive pulmonary disease (COPD) is associated with airway inflammation and bacterial dysbiosis. The relationship between the microbiome bronchial gene expression in COPD poorly understood. We aimed to identify differences from brushings patients healthy individuals investigate whether any distinguishing bacteria are related expression.For this 16S rRNA sequencing host transcriptomic analysis, aged 45-75 years mild-to-moderate either receiving or not inhaled corticosteroids same...
Abstract Activated caspase-1 and caspase-11 induce inflammatory cell death in a process termed pyroptosis. Here we show that Prostaglandin E 2 (PGE ) inhibits caspase-11-dependent pyroptosis murine human macrophages. PGE suppreses expression macrophages the airways of mice with allergic inflammation. Remarkably, caspase-11-deficient are strongly resistant to developing experimental airway inflammation, where is known be protective. Expression elevated lung wild type Blocking production...
Abstract Rationale and Objective Plasma extracellular vesicles (EVs) represent a vital source of molecular information about health disease states. Due to their heterogenous cellular sources, EVs cargo may predict specific pathomechanisms behind phenotypes. Here we aimed utilize EV microRNA (miRNA) signatures gain new insights into underlying mechanisms obesity‐associated low type‐2 asthma. Methods Obese asthma (OA) non‐obese (NOA) patients were selected from an cohort conjointly with...
Alpha1-antitrypsin (AAT) deficiency, although largely under-diagnosed, is the underlying cause of approximately 1% COPD cases. Lack awareness leads to long delays in diagnostic testing. Subsequently, lifestyle and treatment choices with potentially positive effects on prognosis may be postponed.Data testing practices for AAT deficiency were derived from University Pavia, Italy, Marburg, Germany. In addition, a survey physicians was undertaken explore their attitudes toward deficiency.In...
Patients with stable COPD show improvements in exercise capacity and muscular function after the application of whole body vibration. We aimed to evaluate whether this modality added conventional physiotherapy exacerbated hospitalised patients would be safe improve quality life. 49 were randomized (1:1) undergo alone or addition The primary endpoint was between-group difference 6-minute walking test (day discharge – day admission). Secondary assessments included chair rising test, life,...
α 1 -Antitrypsin deficiency (AATD) is a genetically determined disorder that associated with different clinical manifestations. We aimed to assess the prevalence of diagnosed AATD and its comorbidities using large healthcare database. In this retrospective longitudinal observational study, we analysed data from 4 million insurants. Using International Classification Diseases revision 10 (ICD-10) codes, assessed prevalence, utilisation patients (E88.0 repeatedly coded) relative non-AATD...
Abstract Background Chronic obstructive pulmonary disease (COPD) is an inflammatory multisystemic caused by environmental exposures and/or genetic factors. Inherited alpha-1-antitrypsin deficiency (AATD) one of the best recognized factors increasing risk for early onset COPD with emphysema. The aim this study was to gain a better understanding associations between comorbidities and specific biomarkers in patients without AATD enable future investigations aimed, example, at identifying or...
Diagnosis of obstructive sleep apnoea syndrome (OSAS) is technically demanding, cost-intensive and time-consuming. The measurement volatile organic compounds by an electronic nose innovative method that determines distinct molecular patterns exhaled breath in different patient groups. We addressed the following questions: What diagnostic accuracy detection OSAS ability to detect effects standard therapy patients with OSAS? Are these results related changes markers airway inflammation...
To compare the volatile organic compound patterns of patients with COPD and without alpha 1-antitrypsin (AAT) deficiency using electronic nose technology.Exhaled breath condensate pure exhaled (n=10) (n=23) AAT healthy controls were analysed. The effect human recombinant on profile 11 AAT-deficient was also examined. Exhaled measured Cyranose 320. Smell prints analysed by linear discriminant analysis (LDA) Mahalanobis distance (MD) cross-validation values (CVVs).Smell AAT-deficiency...
Despite recognition of asthma as a growing global issue and development guidelines, treatment practices vary between countries. Several studies have reported patients’ perspectives on control. This study presents physicians’ strategies for management. Physicians seeing ≥4 adult patients with per month in Australia, Canada, China, France, Germany, Japan were surveyed (N=1809; ≈300 country). A standardised questionnaire was developed this administered by telephone, online or face-to-face....
Dual bronchodilation combining a long-acting β2-agonist (LABA) and muscarinic antagonist (LAMA) is the preferred choice of treatment recommended by Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 guidelines management patients with moderate-to-severe chronic obstructive pulmonary disease (COPD). The once-daily (q.d.) fixed-dose combination (FDC) LABA, indacaterol 110 μg LAMA, glycopyrronium 50 (IND/GLY 110/50 q.d.) demonstrated superior improvements in lung function,...
EvA (Emphysema versus Airway disease) is a multicentre project to study mechanisms and identify biomarkers of emphysema airway disease in chronic obstructive pulmonary (COPD). The objective this was delineate objectively imaging-based emphysema-dominant disease-dominant phenotypes using quantitative computed tomography (QCT) indices, standardised with novel phantom-based approach. 441 subjects COPD (Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages 1–3) were assessed terms...
Abstract Background Whether the clinical or pathophysiologic significance of “treatable trait” high blood eosinophil count in COPD is same as for asthma remains controversial. We sought to determine relationship between count, characteristics and gene expression from bronchial brushings asthma. Methods Subjects were recruited into a (emphysema versus airway disease [EvA]) cohort (Unbiased BIOmarkers PREDiction respiratory outcomes, U‐BIOPRED). determined using RNAseq EvA (n = 283) Affymetrix...
Influenza A virus (IAV) causes severe respiratory infections and alveolar epithelial damage resulting in acute distress syndrome (ARDS). Extracellular vesicles (EVs) have been shown to mediate cellular crosstalk inflammation by transfer of microRNAs (miRNAs). In this study, we found significant changes the miRNA composition EVs bronchoalveolar lavage fluid from patients with IAV-induced ARDS. Among 9 significantly deregulated microRNAs, miR-17-5p was upregulated patients' BALF IAV-infected...