A5026155191- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Hemodynamic Monitoring and Therapy
- Respiratory Support and Mechanisms
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- Non-Invasive Vital Sign Monitoring
- Cardiac Imaging and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Disease Prevention
- Cardiovascular Function and Risk Factors
- Long-Term Effects of COVID-19
- Blood Pressure and Hypertension Studies
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Electrical and Bioimpedance Tomography
- Pulmonary Hypertension Research and Treatments
- Neonatal Respiratory Health Research
- COVID-19 Clinical Research Studies
- Advanced X-ray and CT Imaging
- Delphi Technique in Research
- Atomic and Subatomic Physics Research
- Pediatric health and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Heidelberg University
2016-2025
University Hospital Heidelberg
2016-2025
Hautklinik Heidelberg
2021-2025
University Medical Centre Mannheim
2015-2024
German Center for Lung Research
2020-2024
Heidelberg University
2024
University of Bern
2023
University Hospital of Bern
2023
Helmholtz Zentrum München
2023
University Children’s Hospital Bern
2023
Abstract Introduction The aim of this study was to evaluate the diagnostic and prognostic value presepsin in patients with severe sepsis septic shock during first week ICU treatment. Methods In total, 116 suspected or were included 24 hours Blood samples for biomarker measurements presepsin, procalcitonin (PCT), interleukin 6 (IL-6), C reactive protein (CRP) white blood cells (WBC) drawn at days 1, 3 8. All followed up six months. Biomarkers tested diagnosis sepsis, prognosis 30-days...
Little is known about the relationship between airway inflammatory phenotypes and some important asthma features such as small dysfunction (SAD).To describe longitudinal impact of on SAD outcomes.We measured eosinophil neutrophil counts in induced sputum at baseline 1 year later to stratify 197 adult patients with into 4 phenotypes. We conducted a comprehensive assessment lung function using spirometry, body plethysmography, impulse oscillometry, inert gas single multiple breath washouts....
BackgroundLittle is known about the role of small airway dysfunction (SAD) and its complex relation with asthma control physical activity (PA).ObjectiveTo investigate interrelations among SAD, risk factors for severity, symptom control, PA.MethodsWe assessed SAD by impulse oscillometry other sophisticated lung function measures including inert gas washout in adults (mild to moderate, n = 140; severe, 128) 69 healthy controls from All Age Asthma Cohort. We evaluated prevalence interrelation...
<b>About half of the patients recovering from SARS-CoV-2 have persistent symptoms and lower lung function as long 2 months after infection. This is common even in younger convalescents with few comorbidities.</b>https://bit.ly/38dyCYB
Small airway dysfunction (SAD) is a key feature of COPD and might present in tobacco-exposed adults with normal spirometry. So far, the role oscillometry-defined SAD this population largely unexplored. To investigate prevalence its associations structural changes, quality life (QoL), metabolic cardiovascular disease (CVD) impaired or preserved airflow. In sub-cohort (n=1628) nested within lung cancer screening trial, we assessed using preBD-spirometry, oscillometry, AI-powered CT. Impaired...
Abstract Patients with primary antibody deficiency are at risk for severe and in many cases prolonged COVID-19. Convalescent plasma treatment of immunocompromised individuals could be an option especially countries limited access to monoclonal therapies. While studies immunocompetent COVID19 patients have demonstrated only a benefit, evidence the safety, timing, effectiveness this antibody-deficient is lacking. Here, we describe 16 treated convalescent four medical centers. In our cohort,...
Impulse oscillometry (IOS) allows an effort-independent evaluation of small airway function in asthma. Unfortunately, well-determined minimal clinically important differences (MCIDs) for IOS measures are lacking. Here, we provide MCIDs frequently used measures, namely frequency dependence resistance (FDR) and area reactance (AX), patients with asthma.We performed at baseline 1 year later adult mild-to-severe asthma (n=235). In a two-step approach, first applied distribution-based method to...
<i>Background:</i> An easy, noninvasive and accurate technique for measuring cardiac output (CO) would be desirable the diagnosis therapy of diseases. Innocor, a novel inert-gas-rebreathing (IGR) system, has shown promising results in smaller studies. extensive evaluation larger, less homogeneous patient collective is lacking. <i>Methods:</i> We prospectively assessed accuracy reproducibility CO measurements obtained by IGR 305 consecutive patients as compared to gold...
Smoking cessation is difficult but maintaining smoke-free without nicotine replacement therapy even harder. During the last few years, several different alternative products, including heated tobacco products (HTP), have been introduced to market. In this study, we investigated acute effects of IQOS
Quantitative computed tomography (qCT) is an emergent technique for diagnostics and research in patients with chronic obstructive pulmonary disease (COPD). qCT parameters demonstrate a correlation function tests symptoms. However, only provides anatomical, not functional, information. We evaluated five distinct, partial-machine learning-based mathematical models to predict lung from values comparison tests.75 diagnosed COPD underwent body plethysmography dose-optimized examination on...
Asthma, obesity and physical activity (PA) are interrelated. However, longitudinal data with objective PA measures direct assessment of body composition still lacking.To study the impact symptom control on composition.In a cohort German Center for Lung Research, we assessed 233 asthma patients 84 healthy controls using bioelectrical impedance analysis. (ie average daily steps time at least moderate activity, steps/min) was measured by accelerometry one week. Asthma ACT score, ACQ-5 score...
Small airway dysfunction (SAD) is a frequent feature of asthma that has been linked to disease severity and poor symptom control. However, little known about the role SAD in nocturnal asthma. To study association between frequency symptoms compared conventional lung function testing. We assessed self-reported through control test. studied impact using Asthma Quality Life Questionnaire (AQLQ) Multidimensional Fatigue Inventory (MFI-20). spirometry, body plethysmography, impulse oscillometry,...
Several substitute products are discussed as a healthier alternative to smoking, thereunder e-cigarettes and smokeless tobacco products, e.g., chewing bags, which increasingly used in this context. We investigated the acute effects of bags compared combustible cigarettes with without nicotine on small airways arterial stiffness head-to-head design. This single-center, four-arm cross-overstudy included 20 healthy occasional smokers (25 ± 0.6 years). On four test days, participants consumed...
Extracellular DNA (e-DNA) and neutrophil extracellular traps (NETs) are linked to asthmatics airway inflammation. However, data demonstrating the characterization of inflammation associated with excessive e-DNA production its impact on asthma outcomes limited.To characterize association control, severe exacerbations pulmonary function, particularly, air trapping small dysfunction.We measured concentrations in induced sputum from 134 patients 28 healthy controls. We studied correlation...
The evidence regarding effects of statins on exacerbation risk in COPD remains controversial. Previous studies often excluded patients with cardiovascular comorbidities despite their high prevalence and role for exacerbations. Based the cardioprotective properties statins, we hypothesised that may reduce exacerbations especially comorbidities. One thousand eight hundred eighty seven German cohort COSYCONET (COPD Systemic Consequences Comorbidities Network) GOLD grades 1-4 (37.8% female, mean...
Abstract Objectives Medical practitioners analyze numerous types of data, often using archaic representations that do not meet their needs. Pneumologists who lung function exams must consult multiple exam records manually, making comparisons cumbersome. Such shortcomings can be addressed with interactive visualizations, but these designed carefully practitioners’ needs in mind. Materials and Methods A workshop experts was conducted to gather user requirements common tasks. Based on the...