A5042330789- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Breast Lesions and Carcinomas
- Chronic Obstructive Pulmonary Disease (COPD) Research
- AI in cancer detection
- Family and Patient Care in Intensive Care Units
- Mechanical Circulatory Support Devices
- Thermal Regulation in Medicine
- Neonatal Respiratory Health Research
- Nosocomial Infections in ICU
- Cardiac Structural Anomalies and Repair
- Vascular Procedures and Complications
- Antifungal resistance and susceptibility
- Obstructive Sleep Apnea Research
- Digital Radiography and Breast Imaging
- Immunotherapy and Immune Responses
- Receptor Mechanisms and Signaling
- Traumatic Brain Injury and Neurovascular Disturbances
- Pleural and Pulmonary Diseases
- Interprofessional Education and Collaboration
- Atherosclerosis and Cardiovascular Diseases
- Takotsubo Cardiomyopathy and Associated Phenomena
- Pneumothorax, Barotrauma, Emphysema
- Bartonella species infections research
German Centre for Cardiovascular Research
2022-2025
Heidelberg University
2016-2025
University Medical Centre Mannheim
2016-2025
University Hospital Heidelberg
2016-2025
Waldburg-Zeil Kliniken
2023
Medizinische Fakultät Mannheim
2022
Oncoscience (Germany)
2022
University Medical Center
2022
University of Mannheim
2017
LMU Klinikum
2005
Objective: Pulsatile flow in Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) for treatment of cardiogenic shock may yield physiological benefits over continuous flow. The primary objective this study was to evaluate whether there are detectable differences between these modes a small single-centre cohort. Methods: We performed retrospective analysis patients who underwent VA-ECMO support at our institution 2019 and 2023. Data collected included demographic information, disease...
Abstract Background Although multidrug-resistant bacteria (MDR) are common in patients undergoing prolonged weaning, there is little data on their impact weaning and patient outcomes. Methods This a retrospective analysis of consecutive who underwent were at university centre from January 2018 to December 2020. The influence MDR colonisation infection success (category 3a 3b), successful invasive mechanical ventilation (IMV) with or without the need for non-invasive (NIV) compared category...
Atherosclerosis, a major contributor to cardiovascular morbidity and mortality, is characterized by chronic inflammation of the arterial wall. This inflammatory process initiated maintained both innate adaptive immunity. Dendritic cells (DCs), which are antigen-presenting cells, play crucial role in development atherosclerosis consist various subtypes with distinct functional abilities. Following recognition binding antigens, DCs become potent activators cellular responses, bridging immune...
Abstract Background Invasive mechanical ventilation (IMV) is a standard therapy for intensive care patients with respiratory failure. With increasing population age and multimorbidity, the number of who cannot be weaned from IMV increases, resulting in impaired quality life high costs. In addition, human resources are tied up these patients. Methods The PRiVENT intervention prospective, mixed-methods interventional, multicentre study parallel comparison group selected insurance claims data...
Long-term invasive mechanical ventilation (IMV) is a major burden for those affected and causes high costs the health care system. Early risk assessment prerequisite best possible support of high-risk patients during weaning process. We aimed to identify factors long-term IMV within 96 h (h) after onset IMV. The analysis was based on data from one Germany's largest statutory insurance funds; who received ≥ were admitted in January 2015 at earliest discharged December 2017 latest analysed....
<b><i>Introduction:</i></b> The most widespread treatment for obstructive sleep apnoea and obesity hypoventilation syndrome is continuous positive airway pressure (CPAP). addition of inspiratory support a potential alternative. This physiological study to determine the effect CPAP on respiratory effort measured by diaphragm thickening fraction (DTF) in healthy volunteers. <b><i>Methods:</i></b> DTF was spontaneously breathing, volunteers during...
Hintergrund Obwohl eine Kolonisation/ Infektion mit multiresistenten Erregern (MRE) bei Patient*innen im prolongierten Weaning klinischen Alltag sehr häufig auftritt, gibt es kaum Daten zu ihrem Einfluss auf das Weaning-Outcome.
Acute myocarditis is commonly associated with viral infections, including severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Myocarditis following mRNA COVID-19 vaccination has also been reported, however this rare and usually resolves within days or weeks. We present a case of reported after mRNA-1273 vaccine (Moderna) diagnosed using cardiac magnetic resonance imaging (CMR). This report describes the utility CMR in diagnosis follow-up such patients parameters which could suggest...
Hintergrund In vielen Bereichen der Pneumologie spielen Genderaspekte eine relevante Rolle. Es ist zwar bekannt, dass Männer im prolongierten Weaning ein schlechteres Outcome haben. Dennoch gibt es keine konkreten Analysen zu diesem Thema.
Fragestellung Es handelt sich um eine physiologische Studie zur Bestimmung der Auswirkung von kontinuierlichem positivem Atemwegsdruck und inspiratorischem Unterstützungsdruck auf die Atemanstrengung, gemessen durch Zwerchfelldickenänderungsrate (diaphragm thickening fraction, DTF) während nicht-invasiven Atemunterstützung bei gesunden Freiwilligen.
PRiVENT (PRevention of invasive VENTilation) is an evaluation a bundle interventions aimed at the prevention long-term mechanical ventilation. One these elements e-learning course for healthcare professionals to improve weaning expertise. The aim our analysis examine implementation in cooperating intensive care units.
Aim Out-of-hospital cardiac arrest (OHCA) is a major health concern in Western societies. Poor outcome after OHCA determined by the extent of hypoxic-ischemic encephalopathy (HIE). Dysregulation iron metabolism has prognostic relevance patients with ischemic stroke and sepsis. The aim this study was to determine whether serum parameters help estimate outcomes OHCA. Methods In prospective single-center study, 70 adult were analyzed. Serum ferritin, iron, transferrin (TRF), TRF saturation...
Introduction and aims Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is an increasingly utilized therapeutic choice in patients with cardiogenic shock, however, high complication rate often counteracts its beneficial cardiopulmonary effects. The assessment of left ventricular (LV) function key the management this population, most commonly used measures LV performance are substantially load-dependent. Non-invasive myocardial work a novel functional measure which may overcome...
The diaphragm thickening fraction (DTF) may be a valuable tool for estimating respiratory effort in non-invasive ventilation. primary aim of this physiological study is the investigation correlation DTF with oesophageal pressure swings (ΔP