A5042806096- Respiratory Support and Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Intensive Care Unit Cognitive Disorders
- Transplantation: Methods and Outcomes
- Family and Patient Care in Intensive Care Units
- Tracheal and airway disorders
- COVID-19 and Mental Health
- Interprofessional Education and Collaboration
- Mechanical Circulatory Support Devices
- Pneumonia and Respiratory Infections
- Palliative Care and End-of-Life Issues
- COVID-19 and healthcare impacts
- Pleural and Pulmonary Diseases
- Airway Management and Intubation Techniques
- Cardiac Arrest and Resuscitation
- Pulmonary Hypertension Research and Treatments
- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Long-Term Effects of COVID-19
- Blood transfusion and management
- Healthcare professionals’ stress and burnout
- Pressure Ulcer Prevention and Management
- Air Quality and Health Impacts
- Inhalation and Respiratory Drug Delivery
Robert Bosch Hospital
2017-2025
Klinik Schillerhöhe
2017-2024
German Respiratory Society
2024
Bosch Health Campus
2024
Löwenstein Medical (Germany)
2023
Robert Bosch (Germany)
2020
Evaluation of pulmonary function impairment after COVID-19 in persistently symptomatic and asymptomatic patients all disease severities characterisation risk factors.Patients with confirmed SARS-CoV-2 infection underwent prospective follow-up testing blood gas analysis during steady-state cycle exercise 4 months acute illness. Pulmonary (PFI) was defined as reduction below 80% predicted DLCOcSB, TLC, FVC, or FEV1. Clinical data were analyzed to identify factors for impaired function.76...
Abstract Background Various complications may arise from prolonged mechanical ventilation, but the risk of tracheal stenosis occurring late after translaryngeal intubation or tracheostomy is less common. This study aimed to determine prevalence, type, factors, and management stenoses in mechanically ventilated tracheotomized patients deemed ready for decannulation following weaning. Methods A retrospective observational on 357 ventilated, admitted a specialized weaning center over seven...
Abstract Background Several studies have assessed predictors of weaning and extubation outcome in short-term mechanically ventilated patients, but there are only few on from prolonged mechanical ventilation. Methods Retrospective, single-center, observational study at a specialized national center Germany. Patients’ medical records were reviewed to obtain data demographics, comorbidities, respiratory indices, the result prospectively documented, standardized spontaneous breathing trial (SBT)...
Background Pulmonary hypertension associated with chronic obstructive pulmonary disease (COPD) contributes to morbidity and mortality. Further characterisation improve management is warranted. The aim of the study was apply recently proposed PH classification assess association lung volume involvement over course in patients advanced COPD. Methods Patients COPD undergoing transplant evaluation, including right heart catheterisation were included irrespective likelihood having PH. Spirometry,...
Interstitial lung [ILD] disease and granulomatous [GLD] are rare respiratory disorders that have been associated with inflammatory bowel [IBD]. Clinical presentation is polymorphic aetiology unclear.This was an ECCO-CONFER project. Cases of concomitant ILD or GLD IBD, drug-induced ILD/GLD, were collected. The criteria for diagnosing based on definitions from the American Thoracic Society European Respiratory discretion reporting clinician.We identified 31 patients ILD. majority had...
Mechanical power (MP) of artificial ventilation, the energy transferred to respiratory system, is a chief determinant adequate oxygenation and decarboxylation. Calculated MP, product applied airway pressure minute may serve as an estimate muscle workload when switching spontaneous breathing. The aim study was assess MP's discriminatory performance in predicting successful weaning from prolonged tracheostomy ventilation.Prospective, observational 130 mechanically ventilated, tracheotomized...
Abstract Background Invasive mechanical ventilation (IMV) is a standard therapy for intensive care patients with respiratory failure. With increasing population age and multimorbidity, the number of who cannot be weaned from IMV increases, resulting in impaired quality life high costs. In addition, human resources are tied up these patients. Methods The PRiVENT intervention prospective, mixed-methods interventional, multicentre study parallel comparison group selected insurance claims data...
Long-term invasive mechanical ventilation (IMV) is a major burden for those affected and causes high costs the health care system. Early risk assessment prerequisite best possible support of high-risk patients during weaning process. We aimed to identify factors long-term IMV within 96 h (h) after onset IMV. The analysis was based on data from one Germany's largest statutory insurance funds; who received ≥ were admitted in January 2015 at earliest discharged December 2017 latest analysed....
Liberation from prolonged tracheostomy ventilation involves ventilator weaning and removal of the tracheal cannula (referred to as decannulation). This study evaluated incidence, causes, predictors unsuccessful decannulation following weaning.Observational retrospective cohort 532 mechanically ventilated, tracheotomized patients treated at a specialized center between June 2013 January 2021. We summarized causes for decannulations used binary logistic regression analysis derive validate...
Abstract Background The impact of anemia and red blood cell (RBC) transfusion on weaning from mechanical ventilation is not known. In theory, transfusions could facilitate liberation the ventilator by improving oxygen transport capacity. contrast, retrospective studies critically ill patients showed a positive correlation with prolonged ventilation, increased mortality rates, risk nosocomial infections, which in turn adversely affect outcome. Methods Retrospective, observational study...
Abstract Since critical respiratory muscle workload is a significant determinant of weaning failure, applied mechanical power (MP) during artificial ventilation may serve for readiness testing before proceeding on spontaneous breathing trial (SBT). Secondary analysis prospective, observational study in 130 prolonged ventilated, tracheotomized patients. Calculated MP’s predictive SBT outcome performance was determined using the area under receiver operating characteristic curve (AUROC),...
Abstract Background Pulmonary infiltrates of variable etiology are one the main reasons for hypoxemic respiratory failure leading to invasive mechanical ventilation. If pulmonary remain unexplained or progress despite treatment, histopathological result a lung biopsy could have significant impact on change in therapy. Surgical is commonly used technique, but due its considerable morbidity and mortality, less bronchoscopic transbronchial (TBLB) may be valuable alternative. Methods...
Evidence suggests differences in ventilation efficiency and respiratory mechanics between early COVID-19 pneumonia classical acute distress syndrome (ARDS), as measured by established ventilatory indexes, such the ratio (VR; a surrogate of pulmonary dead-space fraction) or mechanical power (MP; affected, e.g., changes lung-thorax compliance).
Prolonged pulmonary air leak (PAL) is a common clinical problem, associated with significant morbidity and mortality. There are numerous reports of treatment PAL using endobronchial valves (EBV) in respiratory stable patients, but only few on critically ill there virtually no practical knowledge the mechanically ventilated patients acute distress syndrome (ARDS), treated veno-venous extracorporeal membrane oxygenation (vvECMO). We describe case where EBV placement was performed patient ARDS...
Prolonged mechanical ventilation (PMV) after lung transplantation poses several risks, including higher tracheostomy rates and increased in-hospital mortality. Mechanical power (MP) of artificial unifies the ventilatory variables that determine gas exchange may be related to allograft function following transplant, affecting ventilator weaning. We retrospectively analyzed consecutive double transplant recipients at a national center, ventilated through endotracheal tubes upon ICU admission,...
Staff shortages pose a major challenge to the health system.
Hintergrund Trotz der steigenden Zahl invasiv langzeitbeatmeter Patienten und gesellschaftlichen Bedeutung des Themas wird es in Öffentlichkeit wenig wahrgenommen. Ein Ziel Projekts PRiVENT ist es, die öffentliche Wahrnehmung Langzeitbeatmung durch eine gezielte Kampagne unter Einbeziehung sozialen Medien zu stärken.
Bei der COPD kann sich im Krankheitsverlauf konsekutiv eine Atempumpinsuffizienz mit Hyperkapnie entwickeln, deren Therapie in einer nicht-invasiven Beatmung (NIV) besteht. Hierdurch reduziert die assoziierte Mortalität effektiv. Eine akkurate Vorhersage Entwicklung ist daher für frühzeitige Identifizierung von Risikopatienten Bedeutung. Bislang gibt es keine belastbaren prädiktiven Faktoren assoziierten chronischen Atempumpinsuffizienz, sodass diese Patienten meist erst manifesten...
PRiVENT (PRevention of invasive VENTilation) is an evaluation a bundle interventions aimed at the prevention long-term mechanical ventilation. One these elements e-learning course for healthcare professionals to improve weaning expertise. The aim our analysis examine implementation in cooperating intensive care units.