A5090386245- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Intensive Care Unit Cognitive Disorders
- Neonatal Respiratory Health Research
- Trauma and Emergency Care Studies
- Trauma Management and Diagnosis
- Sepsis Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Pelvic and Acetabular Injuries
- Hemodynamic Monitoring and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Blood transfusion and management
- Ultrasound in Clinical Applications
- Cardiac Structural Anomalies and Repair
- Anesthesia and Pain Management
- Erythropoietin and Anemia Treatment
- Anesthesia and Sedative Agents
- Thermal Regulation in Medicine
- Family and Patient Care in Intensive Care Units
- Abdominal Trauma and Injuries
- Long-Term Effects of COVID-19
- Nausea and vomiting management
- Pleural and Pulmonary Diseases
- Antibiotics Pharmacokinetics and Efficacy
Ostalb-Klinikum Aalen
2023
Universitätsklinikum Würzburg
2009-2021
University of Würzburg
2007-2020
Klinik und Poliklinik für Urologie
2005-2020
Saarland University
2017
European Neuroendocrine Tumor Society
2009-2015
Hospital Universitario de Getafe
2010
Charité - Universitätsmedizin Berlin
2010
Aarhus University Hospital
2010
Hospital Clínico de la Universidad de Chile
2010
Untreated, one third of patients who undergo surgery will have postoperative nausea and vomiting. Although many trials been conducted, the relative benefits prophylactic antiemetic interventions given alone or in combination remain unknown.We enrolled 5199 at high risk for vomiting a randomized, controlled trial factorial design that was powered to evaluate interactions among as three interventions. Of these patients, 4123 were randomly assigned 1 64 possible combinations six interventions:...
BACKGROUND: Extracorporeal membrane oxygenation (ECMO) can be used as an “ultima ratio” strategy in multiple injured patients with severe thoracic trauma. However, systemic anticoagulation during ECMO is recommended and thus traumatic brain injury (TBI) intracranial bleeding are well-accepted contraindications for therapy. METHODS: This report describes three cases of prolonged heparin-free venovenous acute respiratory distress syndrome TBI failing conventional mechanical ventilation....
Whole-body multislice helical computed tomography (MSCT) becomes increasingly important as a diagnostic tool in patients with multiple injuries. We describe time requirement of two different approaches to injuries one whole-body-MSCT (MSCT Trauma-Protocol) the sole radiologic procedure and conventional use radiography, combined abdominal ultrasound organ focused CT (Conventional-Trauma-Protocol).Observational study retrospective analysis requirements for resuscitation, workup transfer...
Whole-body multislice helical CT becomes increasingly important as a diagnostic tool in patients with multiple injuries. Time gain multiple-trauma who require emergency surgery might improve outcome. The authors hypothesised that whole-body computed tomography (MSCT) (MSCT trauma protocol) the initial reduces interval to start (tOR) if compared conventional radiography, combined abdominal ultrasound and organ-focused (conventional protocol). second goal of study was investigate whether...
Background Changes in pulmonary hemodynamics and ventilation/perfusion were proposed as hallmarks of Coronavirus disease 2019 (COVID‐19)–induced acute respiratory distress syndrome (ARDS). Inhaled nitric oxide (iNO) may overcome these issues improve arterial oxygenation. Methods We retrospectively analyzed oxygenation vasoreactivity seven COVID‐19 ARDS patients receiving 20 ppm iNO for 15‐30 minutes. Results The inhalation NO significantly improved All with severe had higher partial...
Bleeding is the most common complication during extracorporeal membrane oxygenation (ECMO). It associated with an increased mortality and represents frequent cause of preliminary ECMO termination. We performed a retrospective analysis in single referral center delineating risk factors therapeutic interventions bleeding adult total 59 patients. The median length support was 158 hours, all-cause 41%. occurred on 40% days. On multivariate analysis, fungal pneumonia only significant factor...
Background: Post‐operative nausea and vomiting (PONV) is a common complication of anaesthesia. This study was conducted in 100 German Turkish patients scheduled for elective surgery under general anaesthesia to assess the amount were willing pay an anti‐emetic that completely prevented PONV. Methods: Post‐operatively, using Dixon’s up down method, completed interactive computer questionnaire with random starting point determine how much their own money they totally effective treatment....
In an acute respiratory distress syndrome, venovenous extracorporeal membrane oxygenation (vvECMO) can rapidly normalize arterial hypoxemia and carbon dioxide tension (PaCO2). Considering the positive relationship between PaCO2 cerebral blood flow, aim of current study was to evaluate regional tissue oxygen saturation (rSO2) during implementation vvECMO. Fifteen syndrome patients with recordings rSO2 by near-infrared spectroscopy before vvECMO until optimization ECMO/ventilator settings were...
Positioning therapy may improve lung recruitment and oxygenation is part of the standard care in severe acute respiratory distress syndrome (ARDS). Venovenous extracorporeal membrane (vvECMO) a rescue strategy that ensure sufficient gas exchange ARDS patients failing conventional therapy. The aim this case series was to describe feasibility pitfalls combining positioning vvECMO with ARDS. A retrospective cohort nine described. received 20 (15–86) hours (median, 25 th 75 percentile) while...
Extracorporeal membrane oxygenation (ECMO) is increasingly used in ARDS patients with hypoxemia and/or severe hypercapnia refractory to conventional treatment strategies. However, it associated intracranial complications, e.g. ischemic or hemorrhagic stroke. The arterial carbon dioxide partial pressure (PaCO2) one of the main determinants influencing cerebral blood flow and oxygenation. Since CO2 removal highly effective during ECMO, reduction may lead alterations perfusion. We report on...
Perioperative anaemia leads to impaired oxygen supply with a risk of vital organ ischaemia. In healthy and fit individuals, can be compensated by several mechanisms. Elderly patients, however, have less compensatory mechanisms because multiple co-morbidities age-related decline functional reserves. The purpose the study is evaluate whether elderly surgical patients may benefit from liberal red blood cell (RBC) transfusion strategy compared restrictive strategy.The LIBERAL Trial prospective,...
Background: Proportions of patients dying from the coronavirus disease-19 (COVID-19) vary between different countries. We report characteristics; clinical course and outcome requiring intensive care due to COVID-19 induced acute respiratory distress syndrome (ARDS). Methods: This is a retrospective, observational multicentre study in five German secondary or tertiary hospitals. All consecutively admitted unit (ICU) any participating hospitals March 12 May 4, 2020 with ARDS were included....
Abstract Background Invasive mechanical ventilation (IMV) is a standard therapy for intensive care patients with respiratory failure. With increasing population age and multimorbidity, the number of who cannot be weaned from IMV increases, resulting in impaired quality life high costs. In addition, human resources are tied up these patients. Methods The PRiVENT intervention prospective, mixed-methods interventional, multicentre study parallel comparison group selected insurance claims data...
Objective of this study is to determine whether the formulation standard operating procedures (SOPs) and their incorporation in a trauma pathway are associated with an improvement treatment process.A retrospective data analysis traumatized patients treated before introduction SOPs (group I) after SOP training period 6 months II) was performed. The time required for resuscitation (period A), diagnostic workup B) total stay emergency room C) used as marker team performance. Data described...
Pumpless arteriovenous extracorporeal lung assist is increasingly used as a rescue therapy in acute respiratory distress syndrome. Arteriovenous highly efficient eliminating carbon dioxide and allows the application of ventilator techniques that prioritize protection aim to reduce ventilator-induced injury remote organ dysfunction.Retrospective data analysis performed 12-bed university hospital ICU. In all, 22 patients with syndrome refractory standard care were included. central part...
Abstract Background Acute respiratory distress syndrome (ARDS) is a complex clinical diagnosis with various possible etiologies. One common feature, however, pulmonary permeability edema, which leads to an increased alveolar diffusion pathway and, subsequently, impaired oxygenation and decarboxylation. A novel inhaled peptide agent (AP301, solnatide) was shown markedly reduce edema in animal models of ARDS be safe administer healthy humans Phase I trial. Here, we present the protocol for IIB...
Long-term invasive mechanical ventilation (IMV) is a major burden for those affected and causes high costs the health care system. Early risk assessment prerequisite best possible support of high-risk patients during weaning process. We aimed to identify factors long-term IMV within 96 h (h) after onset IMV. The analysis was based on data from one Germany's largest statutory insurance funds; who received ≥ were admitted in January 2015 at earliest discharged December 2017 latest analysed....
Surfactant depletion is most often used to study acute respiratory failure in animal models. Because model stability criticized, the authors tested following hypotheses: Repeated pulmonary lavage with normal saline provides stable experimental conditions for 24 hours a PaO2/FiO2 ratio < 300 mm Hg. Lung injury was induced by bilateral lavages 8 female pigs (51.5 +/- 4.8 kg). The animals were ventilated (PEEP: 5 cm H2O; tidal volume: 6 mL/kg; rate: 30/min). After euthanized. For histopathology...
Abstract Background Coronavirus disease 2019 (COVID-19) associated coagulopathy (CAC) leads to thromboembolic events in a high number of critically ill COVID-19 patients. However, specific diagnostic or therapeutic algorithms for CAC have not been established. In the current study, we analyzed coagulation abnormalities with point-of-care testing (POCT) and their relation hemostatic complications patients suffering from induced Acute Respiratory Distress Syndrome (ARDS). Our hypothesis was...
We studied the anatomy of sciatic nerve and its division into tibial peroneal part using handheld ultrasound in adults. wanted to evaluate feasibility ultrasound-guided identification popliteal fossa correlation findings by with patients' characteristics.74 volunteers were randomly selected. Using a system 5-10 MHz linear array probe back thigh examined measured. caliper distance joint line was The depicted ultrasound.We could depict all 53 74 (72%) volunteers. position showed large anatomic...