A5061503436- Neonatal Respiratory Health Research
- Cardiac, Anesthesia and Surgical Outcomes
- Birth, Development, and Health
- Immune Response and Inflammation
- Fatty Acid Research and Health
- Respiratory Support and Mechanisms
- Blood transfusion and management
- Traumatic Brain Injury and Neurovascular Disturbances
- Hemodynamic Monitoring and Therapy
- Breast Cancer Treatment Studies
- Cardiac and Coronary Surgery Techniques
- Congenital Diaphragmatic Hernia Studies
- Cardiac Arrest and Resuscitation
- Male Breast Health Studies
- Cardiac Ischemia and Reperfusion
- Cancer Treatment and Pharmacology
- Air Quality and Health Impacts
- Pregnancy and preeclampsia studies
- Erythropoietin and Anemia Treatment
- BRCA gene mutations in cancer
- Sulfur Compounds in Biology
- Intracranial Aneurysms: Treatment and Complications
- Anesthesia and Neurotoxicity Research
- Sepsis Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
The University of Texas Southwestern Medical Center
2024-2025
University Hospital Bonn
2011-2024
University of Bonn
2004-2023
University Medical Center
2022
Society of Interventional Radiology
2021
Deutsche Gesellschaft für Anästhesiologie und Intensivmedizin
2004-2020
Nationwide Children's Hospital
2010-2014
The Ohio State University
2010-2012
Lung Institute
2012
Laboratoire de Physique Corpusculaire de Caen
2006
Air pollution is a pervasive environmental health hazard that occurs over lifetime of exposure in individuals from many industrialized societies. However, studies have focused primarily on durations correspond to only portion the lifespan. We therefore tested hypothesis considerable lifespan would induce maladaptive cardiovascular responses.C57BL/6 male mice were exposed concentrated ambient particles <2.5 µm (particulate matter, PM or PM(2.5)) filtered air (FA), 6 h/d, 5 d/wk, for 9 months....
A 79-year-old male was hospitalized due to fatigue, shortness of breath, and recurrent syncopes.He denied symptoms fever or pain.He had a previous history asthma.No cardiovascular disease reported, cardiac check-ups were unremarkable (last described left ventricular ejection fraction 65%).Initial physical examination in the emergency department revealed heart rate 75 bpm, blood pressure 101/64 mm Hg, body temperature 35.6°C, oxygen saturation 94%, moderate wheezing on auscultation.On initial...
BackgroundPatient Blood Management (PBM) is a patient-centred, systematic, evidence-based approach to improve patient outcomes by managing and preserving patient's own blood whilst promoting safety empowerment. The effectiveness of PBM over longer period have not yet been investigated.MethodsWe performed prospectively designed, multicentre follow-up study with non-inferiority design. Data were retrospectively extracted case-based from electronic hospital information systems. All in-hospital...
Systemic maternal inflammation contributes to preterm birth and is associated with development of bronchopulmonary dysplasia (BPD). Infants BPD exhibit decreased alveolarization, diffuse interstitial fibrosis thickened alveolar septa, impaired pulmonary function. We tested the hypothesis that systemic prenatal LPS administration pregnant mice followed by postnatal hyperoxia exposure prolonged alterations in structure function after return room air (RA) are more severe than alone....
Exposure to ambient air pollution contributes the progression of cardiovascular disease, particularly in susceptible populations. The objective present study was determine whether early life exposure causes persistent consequences measured at adulthood. Pregnant FVB mice were exposed filtered (FA) or concentrated particulate matter (PM2.5) during gestation and nursing. Mice PM2.5 an average concentration 51.69 μg/m(3) from Columbus, OH region for 6 h/day, 7 days/wk utero until weaning 3 wk...
Background Myocardial injury and inflammation at cardiac MRI in patients with COVID-19 have been described recent publications. Concurrently, a chronic syndrome (CCS) after SARS-CoV-2 infection has observed manifests symptoms such as fatigue exertional dyspnea. Purpose To explore the relationship between CCS myocardial an underlying cause of persistent complaints previously healthy individuals. Materials Methods In this prospective study from January 2021 to April 2021, participants without...
Myocardial function is severely compromised during sepsis. Several underlying mechanisms have been proposed. The innate immune system, i.e. toll-like receptor (TLR) 2 and 4, significantly contributes to cardiac dysfunction. Little known regarding TLR9 its pathogenic ligand bacterial DNA in the myocardium. We therefore studied role of myocardial inflammation contractility.Wild-type (WT, C57BL/6) TLR9-deficient (TLR9-D) mice isolated cardiomyocytes were challenged with synthetic (CpG-ODN)....
Particulate matter (PM; PM
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S ARS-CoV-2 infection, and the resulting COVID-19, has become a worldwide pandemic.Although primarily affecting respiratory system, COVID-19-associated myocardial injury is common can occur directly due to viral infection or indirectly systemic inflammation, endothelial activation, and/or microvascular thrombosis (1,2).Besides infarction, also be result of inflammation (2).However, current information about associated mainly limited case reports series (3).As cardiac MRI important for...
The intersection of coronavirus (COVID-19) and heart disease has emerged as a critical nexus in the landscape global health. Individuals with face elevated risks when infected Severe Acute Respiratory-Syndrome Coronavirus-type-2 (SARS-CoV-2) leading to COVID-19. virus can directly affect heart, resulting myocarditis, arrhythmias, failure, even individuals without prior medical cardiac history. Therefore, tools identifying patients infestation predicting severity are utmost importance. This...
Bacterial DNA containing motifs of unmethylated CpG dinucleotides (CpG-ODN) initiate an innate immune response mediated by the pattern recognition receptor Toll-like 9 (TLR9). This leads in particular to expression proinflammatory mediators such as tumor necrosis factor (TNF-alpha) and interleukin-1beta (IL-1beta). TLR9 is expressed human murine pulmonary tissue induction has been linked development acute lung injury. Therefore, hypothesis was tested whether CpG-ODN administration induces...
Inflammation and Toll-like receptor (TLR) signalling have been linked to the development of cardiac hypertrophy following transverse aortic constriction (TAC). In present study, we investigated whether pre-treatment with synthetic TLR9 ligands 1668-thioate or 1612-thioate modulates progression TAC-induced inflammation hypertrophy.C57BL/6N-mice were pre-treated 1668-thioate, (0.25 nmol/g, i.p.), phosphate-buffered saline 16 h prior TAC sham surgery. Heart-weight/body-weight ratio (HW/BW),...
The impact of the neonatal environment on development adult cardiovascular disease is poorly understood. Systemic maternal inflammation linked to growth retardation, preterm birth, and maturation deficits in developing fetus. Often or small-for-gestational age infants require medical interventions such as oxygen therapy. long-term pathological consequences an immature physiology remain unknown. In present study, we hypothesized that systemic hyperoxia exposure compromise cardiac structure,...
Maternally derived inflammatory mediators, such as IL-6 and IL-8, contribute to preterm delivery, low birth weight, respiratory insufficiency, which are routinely treated with oxygen. Premature infants at risk for developing adult-onset cardiac, metabolic, pulmonary diseases. Long-term consequences of perinatal inflammation unclear. We tested the hypothesis that a hostile environment induces profibrotic pathways resulting in fibrosis, including persistently altered lung structure function....
Inflammation and oxygen toxicity increase free radical production contribute to the development of acute respiratory distress syndrome (ARDS), which is a significant cause morbidity mortality in intensive care patients. We have previously reported increased glutathione (GSH) levels lung epithelial cells vitro attenuated adult murine hyperoxic injury vivo after pharmacological thioredoxin reductase-1 (TrxR1) inhibition. Using ARDS model, we tested hypothesis that aurothioglucose (ATG)...