A5035763892- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Obsessive-Compulsive Spectrum Disorders
- Neurotransmitter Receptor Influence on Behavior
- Autism Spectrum Disorder Research
- Receptor Mechanisms and Signaling
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Cannabis and Cannabinoid Research
- Patient Safety and Medication Errors
- Eating Disorders and Behaviors
- Medical Practices and Rehabilitation
- Frailty in Older Adults
- Hormonal Regulation and Hypertension
- Neurogenesis and neuroplasticity mechanisms
- Blood donation and transfusion practices
- Thermal Regulation in Medicine
- Radiation Dose and Imaging
- Advanced Fluorescence Microscopy Techniques
- Biochemical Analysis and Sensing Techniques
- Behavioral and Psychological Studies
- Airway Management and Intubation Techniques
University Hospital Bonn
2013-2024
University of Bonn
2005-2013
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2013
BackgroundPatient Blood Management (PBM) is a patient-centred, systematic, evidence-based approach to improve patient outcomes by managing and preserving patient's own blood whilst promoting safety empowerment. The effectiveness of PBM over longer period have not yet been investigated.MethodsWe performed prospectively designed, multicentre follow-up study with non-inferiority design. Data were retrospectively extracted case-based from electronic hospital information systems. All in-hospital...
Postoperative delirium (POD) is a relevant and underdiagnosed complication after cardiac surgery that associated with increased intensive care unit (ICU) hospital length of stay (LOS). The aim this subgroup study was to compare the frequency tested POD versus coded International Statistical Classification Diseases Related Health Problems (ICD) diagnosis evaluate influence on LOS in ICU hospital.254 elective patients (mean age, 70.5 ± 6.4 years) at University Hospital Bonn between September...
Abstract Purpose Postoperative delirium (POD) is an often unrecognized adverse event in older people after surgery. The aim of this subgroup analysis the PR e- O perative P rediction postoperative DE lirium by appropriate SC reening (PROPDESC) trial patients aged 70 years and was to identify preoperative risk factors impact POD on length stay (LOS) intensive care unit (ICU) hospital. Methods Of total 1097 recruited at a German university hospital (from September 2018 October 2019) PROPDESC...
Abstract Dysregulations of central noradrenergic and serotonergic neurotransmission have been suggested to contribute the pathogenesis neuropsychiatric disorders such as depression. The norepinephrine transporter (NET; SLC6A2) serotonin (5‐HT) 1A receptor (5‐HT receptor; HTR1A) play an important role in nervous monoaminergic homeostasis. As shown previously, variations human NET 5‐HT genes can alter signaling brain: a single nucleotide polymorphism (SNP) coding region gene resulting F528C...
To develop and validate a pragmatic risk screening score for postoperative delirium (POD) based on routine preoperative data.Prospective observational monocentric trial.Preoperative data POD assessment were collected from cardiac non-cardiac surgical patients at German university hospital. Data-driven modelling approaches (step-wise vs. component-wise gradient boosting complete restricted predictor set) compared to selection by experts (investigators external Delphi survey).Inpatients (≥60...
Recently, an association of the Val66Met polymorphism brain-derived neurotrophic factor with hippocampal volume in patients major depression has been reported. Here, we aimed at replicating this finding independent German sample. We included 79 unipolar depressive episodes and 84 healthy comparison participants. The was determined all hippocampus manually traced on high-resolution magnetic resonance images. volumes were significantly smaller than those participants, confirming previous...
Variant rs2522833 of the Piccolo-encoding gene PCLO has recently been found to be associated with major depressive disorder (MDD). encodes a presynaptic cytomatrix protein which influences monoamine neurotransmitter release. Piccolo could therefore play an important role in treatment response antidepressant therapy and improvement alterations HPA system reactivity. We investigated influence coding variant on 205 in-patients unipolar depression. Treatment was measured (1) at level...
Major depressive disorder (MDD) is accompanied by both cognitive impairments and a hyperactivity of the hypothalamic-pituitary-adrenocortical (HPA) system, resulting in an enhanced glucocorticoid secretion. Cortisol acts via mineralocorticoid receptors densely located hippocampus, brain area that important regarding functions especially memory functions. Recently, variant (rs1545843) affecting transcription human SLC6A15 gene has been associated with depression genome-wide association study....
Objectives Prehospital hypothermia is defined as a core temperature <36.0°C and has been shown to be an independent risk factor for early death in patients with trauma. In retrospective study, possible correlation between the body at time of admission emergency room subsequent in-hospital transfusion requirements mortality rate was explored. Setting This single-centre study primary care hospital Germany. Participants 15 895 were included this study. Patients classified by rate. Excluded...
Background: Postoperative delirium (POD) ranks among the most common complications in surgical patients. Blood-based biomarkers might help identify patient at risk. This study aimed to assess how serum with specificity for vascular and endothelial function inflammation are altered, prior or following surgery patients who subsequently develop POD. Methods: was a on subcohort of consecutively recruited elective non-cardiac as well cardiac (age > 60 years) single-center PROPDESC trial German...
Postoperative Delirium (POD) is the most common complication of elderly patients after surgery associated with increased postoperative morbidity, persistent care dependency and even mortality. Prevention POD requires detection at high risk prior to surgery. PROPDESC intends provide an instrument for preoperative routine screening patients' POD.PROPDESC a monocentric prospective observatory trial including 1000 older than 60 years from various disciplines university hospital planned least...
Abstract Neuropeptide S (NPS) is a novel central acting neuropeptide that modulates several brain functions. NPS has shown strong anxiolytic-like effects and interactions with other transmitter systems, including serotonin glutamate. A coding variation (Asn107Ile) of the receptor gene (NPSR1) was associated panic disorder schizophrenia. Based on these encouraging findings, present study aimed at exploring potential role NPSR1 in obsessive–compulsive (OCD). sample 232 OCD patients...
Abstract Background Postoperative delirium (POD) is a common postoperative complication, especially in patients over 60 years, with an incidence ranging from 15% to 50%. In most cases, POD manifests the first 5 days after surgery. Multiple contributing risk factors for have been detected. Besides predisposing such as higher age, cognitive impairment, high blood pressure, atrial fibrillation, and past stroke, pathophysiological mechanisms like neuroinflammation are also considered factors....
Zusammenfassung Ziel der Studie: Studie war Vergleich Zufriedenheit von Patienten eines Regelversorgers mit Universitätsklinikums. Aus Wichtigkeit des Parameters und ermittelter wurde ein Patientenzufriedenheits-Index berechnet. Mittel- bis langfristig soll so die Wettbewerbsfähigkeit Auslastung Krankenhauses optimiert werden sowie vorhandene Ressourcen kosteneffizient zur Steigerung Attraktivität eingesetzt werden. Methode: Die Autoren führten eine fragebogengestützte Erhebung in einem...
Postoperative delirium is a common complication in patients after cardiac surgery, especially older patients, and can manifest as disturbance of attention consciousness. It lead to increased postoperative morbidity, prolonged need for care, mortality. The presented study investigates whether the occurrence surgery be prevented by multisensory stimulation. was conducted prospective, randomized, controlled, non-pharmacological intervention years 2021 2022 at University Hospital Bonn Germany. A...