A5077390693- Advanced MRI Techniques and Applications
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Nutrition and Health in Aging
- Cardiac Imaging and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Infective Endocarditis Diagnosis and Management
- Cancer Immunotherapy and Biomarkers
- Body Composition Measurement Techniques
- Cerebrovascular and Carotid Artery Diseases
- Health Literacy and Information Accessibility
- Cardiac Structural Anomalies and Repair
- Viral Infections and Immunology Research
- Atomic and Subatomic Physics Research
- Cardiovascular Function and Risk Factors
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- MRI in cancer diagnosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Lung Cancer Diagnosis and Treatment
- Bone and Joint Diseases
- Genetic Neurodegenerative Diseases
- Venous Thromboembolism Diagnosis and Management
- Cardiac Valve Diseases and Treatments
Medizinische Hochschule Hannover
2025
University Hospital Bonn
2014-2023
University of Bonn
2017-2022
Society of Interventional Radiology
2021
Universitätsklinikum Aachen
2018-2020
RWTH Aachen University
2018-2019
Klinik und Poliklinik für Mund-, Kiefer- und Plastische Gesichtschirurgie
2015-2016
BG Klinik Tübingen
2014-2015
University of Tübingen
2014
To compare the diagnostic performance of original Lake Louise criteria (LLC) and 2018 LLC for diagnosis acute myocarditis simultaneously validate previously reported cutoff values parametric mapping techniques.A total 40 patients with 26 control participants underwent cardiac MRI. Cardiac MRI protocol allowed assessment T2 signal intensity ratio, early gadolinium enhancement late enhancement, T1 relaxation times, extracellular volume fraction, times. The were assessed, differences between...
<h3>BACKGROUND AND PURPOSE:</h3> The rupture of an intracranial aneurysm is a serious incident, causing subarachnoid hemorrhage associated with high fatality and morbidity rates. Because the demand for radiologic examinations steadily growing, physician fatigue due to increased workload real concern may lead mistaken diagnoses potentially relevant findings. Our aim was develop sufficient system automated detection aneurysms. <h3>MATERIALS METHODS:</h3> In retrospective study, we established...
Abstract Computed tomography (CT) and magnetic resonance imaging (MRI) can quantify muscle mass quality. However, it is still unclear if CT MRI derived measurements be used interchangeable. In this prospective study, fifty consecutive participants of a cancer screening program underwent same day low-dose chest MRI. Cross-sectional areas (CSA) the paraspinal skeletal muscles were obtained. fat infiltration (MFI) assessed by mean radiodensity in Hounsfield units (HU) proton density fraction...
Cardiac tissue remodeling in the course of chronic left ventricular hypertrophy requires phagocytes which degrade cellular debris, initiate and maintain inflammation reorganization. The dynamics have not been systematically studied. Here, we characterized temporal accumulation leukocytes cardiac immune response by flow cytometry fluorescence microscopy at day 3, 6 21 following transverse aortic constriction (TAC). due to pressure overload causes represented an increase cells all three time...
Background Cardiac involvement in liver cirrhosis the absence of underlying cardiac disease is termed cirrhotic cardiomyopathy. The pathophysiology this condition still poorly understood. Purpose To investigate extent subclinical imaging changes terms fibrosis and inflammation to explore relationship between severity degree myocardial involvement. Materials Methods In prospective study from November 2018 December 2019, participants with healthy control underwent hepatic MRI. multiparametric...
Objective Body composition comprises prognostic information in patients with various malignancies and can be opportunistically determined from routine computed tomography (CT) scans. However, accurate assessment of alterations, for example, due to ascites or anasarca, identification intermuscular fat remain challenging. In this study, we aimed develop a fully automated highly segmentation tool connective tissue compartments abdominal CT scans using the open-source Convolutional Neural...
Background Myocardial injury and inflammation at cardiac MRI in patients with COVID-19 have been described recent publications. Concurrently, a chronic syndrome (CCS) after SARS-CoV-2 infection has observed manifests symptoms such as fatigue exertional dyspnea. Purpose To explore the relationship between CCS myocardial an underlying cause of persistent complaints previously healthy individuals. Materials Methods In this prospective study from January 2021 to April 2021, participants without...
Background Immune checkpoint inhibitors (ICIs) for cancer treatment are associated with a spectrum of immune-related adverse events, including ICI-induced myocarditis; however, the extent subclinical acute cardiac effects related to ICI is unclear. Purpose To explore injury and inflammation therapy that can be detected use MRI. Materials Methods In this prospective study from November 2019 April 2021, oncologic participants, without known underlying structural heart disease or symptoms,...
Background Chemical shift‐encoding based water‐fat MRI is an emerging method to noninvasively assess proton density fat fraction (PDFF), a promising quantitative imaging biomarker for estimating tissue concentration. However, in vivo validation of PDFF still lacking bone marrow applications. Purpose To determine the accuracy and precision MRI‐determined vertebral among different readers across field strengths imager manufacturers. Study Type Repeatability/reproducibility. Subjects...
Abstract Objectives To develop a pipeline for automated body composition analysis and skeletal muscle assessment with integrated quality control large-scale application in opportunistic imaging. Methods First, convolutional neural network extraction of single slice at the L3/L4 lumbar level was developed on CT scans 240 patients applying nnU-Net framework. Second, 2D competitive dense fully U-Net segmentation visceral subcutaneous adipose tissue (VAT, SAT), (SM), subsequent determination...
To investigate the diagnostic performance of deep transfer learning (DTL) to detect liver cirrhosis from clinical MRI.The dataset for this retrospective analysis consisted 713 (343 female) patients who underwent MRI between 2017 and 2019. In total, 553 these subjects had a confirmed diagnosis cirrhosis, while remainder no history disease. T2-weighted slices at level caudate lobe were manually exported DTL analysis. Data randomly split into training, validation, test sets (70%/15%/15%). A...
S ARS-CoV-2 infection, and the resulting COVID-19, has become a worldwide pandemic.Although primarily affecting respiratory system, COVID-19-associated myocardial injury is common can occur directly due to viral infection or indirectly systemic inflammation, endothelial activation, and/or microvascular thrombosis (1,2).Besides infarction, also be result of inflammation (2).However, current information about associated mainly limited case reports series (3).As cardiac MRI important for...
Neurosurgical resection represents an important therapeutic pillar in patients with brain metastasis (BM). Such extended treatment modalities require preoperative assessment of patients’ physical status to estimate individual success. The aim the present study was analyze predictive value frailty and sarcopenia as tools for physiological integrity non-small cell lung cancer (NSCLC) who had undergone surgery BM. Between 2013 2018, 141 were surgically treated BM from NSCLC at authors’...
Abstract Although CT and MRI are standard procedures in cirrhosis diagnosis, differentiation of etiology based on imaging is not established. This proof-of-concept study explores the potential deep learning (DL) to support imaging-based liver cirrhosis. retrospective, monocentric included 465 patients with confirmed diagnosis (a) alcoholic (n = 221) (b) other-than-alcoholic 244) Standard T2-weighted single-slice images at caudate lobe level were randomly split for training fivefold...
Abstract Objectives In patients with advanced liver disease, portal hypertension is an important risk factor, leading to complications such as esophageal variceal bleeding, ascites, and hepatic encephalopathy. This study aimed determine the diagnostic value of T1 T2 mapping extracellular volume fraction (ECV) for non-invasive assessment hypertension. Methods this prospective study, 50 participants (33 indication trans-jugular intrahepatic portosystemic shunt (TIPS) 17 healthy volunteers)...
Previous studies suggest an impact of body composition on outcome in melanoma patients. We aimed to determine the prognostic value CT-based assessment patients receiving immune checkpoint inhibitor therapy for treatment metastatic disease using a deep learning approach. One hundred seven with staging CT examinations prior initiation inhibition between January 2013 and August 2019 were retrospectively evaluated. Using automated learning-based analysis pipeline, parameters estimation skeletal...
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease, characterized by bile duct inflammation and destruction, leading to biliary fibrosis cirrhosis. The purpose of this study was investigate the utility T1 T2 mapping parameters, including extracellular volume fraction (ECV) for non-invasive assessment severity in patients with PSC.In prospective study, PSC diagnosis were consecutively enrolled from January 2019 July 2020 underwent MRI. Besides morphological sequences,...
Medication-related osteonecrosis of the jaw (MRONJ) is a well known side-effect anti-resorptive drugs. Changes in bone density might potentially constitute development ONJ. This study aimed to investigate, which degree bisphosphonates (bp) and denosumab (db) induce changes that can be determined from routine diagnostic CT.CT scans 101 patients were investigated. MRONJ was present 61 (n = 26: db-treated; n 35 bp-treated). 40 included as reference group. Bone measured at two distinct locations...