A5086231459- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Cardiac Imaging and Diagnostics
- Stellar, planetary, and galactic studies
- Advanced Neuroimaging Techniques and Applications
- Astronomy and Astrophysical Research
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Astrophysics and Star Formation Studies
- Atomic and Subatomic Physics Research
- Liver Disease and Transplantation
- Medical Imaging Techniques and Applications
- Cardiovascular Function and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- Lymphatic Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Lanthanide and Transition Metal Complexes
- Astronomical Observations and Instrumentation
- Astro and Planetary Science
- Cardiac Valve Diseases and Treatments
- Shoulder Injury and Treatment
- Glioma Diagnosis and Treatment
- Ultrasound and Hyperthermia Applications
- Breast Lesions and Carcinomas
University of Bonn
2013-2025
University Hospital Bonn
2015-2025
Government of the Republic of Korea
2020
Universitätsklinik für Strahlentherapie
1983-2019
German Center for Neurodegenerative Diseases
2012-2018
Philips (Finland)
2016
Creative Commons
2016
University Hospital Cologne
2016
Philips (Germany)
2007-2016
RWTH Aachen University
1988-2014
To compare the effectiveness of mammography, breast ultrasound, and magnetic resonance imaging (MRI) for surveillance women at increased familial risk cancer (lifetime 20% or more).We conducted a cohort study 529 asymptomatic who, based on their family history and/or mutational analysis, were suspected proven to carry susceptibility gene (BRCA). A total 1,542 annual rounds completed with mean follow-up 5.3 years. Diagnostic accuracies three modalities used alone in different combinations...
We investigated whether an abbreviated protocol (AP), consisting of only one pre- and postcontrast acquisition their derived images (first subtracted [FAST] maximum-intensity projection [MIP] images), was suitable for breast magnetic resonance imaging (MRI) screening.We conducted a prospective observational reader study in 443 women at mildly to moderately increased risk who underwent 606 screening MRIs. Eligible had normal or benign digital mammograms and, those with heterogeneously dense...
PURPOSE: To compare magnetic resonance (MR) imaging with conventional in screening high-risk women. MATERIALS AND METHODS: This prospective trial included 192 asymptomatic and six symptomatic women who, on the basis of personal or family history genetic analysis, were suspected proved to carry a breast cancer susceptibility gene. RESULTS: Fifteen cancers identified: nine (six first three second round) patients. Concerning women, four detected correctly classified mammography ultrasonography...
We investigated the respective contribution (in terms of cancer yield and stage at diagnosis) clinical breast examination (CBE), mammography, ultrasound, quality-assured magnetic resonance imaging (MRI), used alone or in different combination, for screening women elevated risk cancer.Prospective multicenter observational cohort study. Six hundred eighty-seven asymptomatic familial (> = 20% lifetime) underwent 1,679 annual rounds consisting CBE, MRI, read independently combinations. In a...
Purpose To investigate the utility and accuracy of breast magnetic resonance (MR) imaging as a supplemental screening tool in women at average risk for cancer to types detected with MR screening. Materials Methods This prospective observational study was conducted two academic centers aged 40-70 years without cancer-associated factors (lifetime <15%). Between January 2005 December 2013, least minimal residual tissue (American College Radiology categories A-D) normal conventional findings...
To identify biological evidence for Alzheimer disease (AD) in individuals with subjective memory impairment (SMI) and unimpaired cognitive performance to investigate the longitudinal course these subjects.[¹⁸F]fluoro-2-deoxyglucose PET (FDG-PET) structural MRI were acquired 31 subjects SMI 56 controls. Cognitive follow-up testing was performed (average time: 35 months). Differences baseline brain imaging data decline assessed between both groups. Associations of tested.The group showed...
PURPOSE: To investigate prospectively the trade-off between temporal and spatial resolution in dynamic contrast material–enhanced bilateral magnetic resonance (MR) imaging of breast. MATERIALS AND METHODS: Informed consent institutional review board approval were obtained. An intraindividual comparative study was performed 30 patients (mean age, 53 years; age range, 27–70 years) with a total 54 enhancing lesions (28 benign 26 malignant) who underwent MR breast twice, once standard protocol...
The purpose of the present study was to evaluate a strategy for safe performance extrathoracic magnetic resonance imaging (MRI) in non-pacemaker-dependent patients with cardiac pacemakers.Inclusion criteria were presence pacemaker and urgent clinical need an MRI examination. Pacemaker-dependent those requiring examinations thoracic region excluded. group consisted 82 who underwent total 115 at 1.5T. To minimize radiofrequency-related lead heating, specific absorption rate limited 1.5 W/kg....
Abstract Purpose To measure 1 H relaxation times of cerebral metabolites at 3 T and to investigate regional variations within the brain. Materials Methods Investigations were performed on a 3.0‐T clinical whole‐body magnetic resonance (MR) system. T2 N‐acetyl aspartate (NAA), total creatine (tCr), choline compounds (Cho) measured in six brain regions 42 healthy subjects. T1 these myo‐inositol (Ins) determined occipital white matter (WM), frontal lobe, motor cortex 10 Results values all...
Magnetic resonance (MR) diffusion measurements of the abdomen were performed in 12 healthy volunteers by using a diffusion-weighted single-shot sequence both without and with pulse triggering for different trigger delays. Pulse to diastolic heart phase led reduced motion artifacts on MR images significantly improved accuracy reproducibility apparent coefficients, or ADCs, abdominal organs. © RSNA, 2002
PURPOSE: To evaluate the usefulness of preoperative magnetic resonance (MR) imaging-guided stereotactic localization and core biopsy suspicious breast lesions that are visible at MR imaging alone (ie, clinically, mammographically, ultrasonographically occult), with goal integrating this technique into diagnostic therapeutic work-up MR-suspicious in a clinical setting. MATERIALS AND METHODS: A device was used for needle placement guide wire 97 66 patients or five patients; all were imaging....
<i>Background/Aims:</i> Subjective memory impairment (SMI) has been suggested as a manifestation of Alzheimer’s Disease (AD) preceding mild cognitive (MCI). In this study, we determined the volumes hippocampus, entorhinal cortex (EC) and amygdala to provide biological evidence for AD in SMI. <i>Methods:</i> Regional volumetric measures were manually traced on 3-Tesla MRI scans. <i>Results:</i> Total brain volume did not differ between groups. Individuals...
Purpose: To establish a pulse sequence for dynamic contrast material–enhanced magnetic resonance (MR) imaging of the breast at 3.0 T and to prospectively compare MR with 1.5 in same patients. Materials Methods: A prospective intraindividual internal review board–approved study was performed 37 women 53 lesions (25 cancers, 28 benign focal lesions) who underwent contrast-enhanced bilateral subtraction twice, once standard technique (voxel size, 1.44 mm3) 0.45–0.72 variable repetition time...
To investigate the impact of a higher magnetic field strength 3 Tesla (T) on detection rate cortical lesions in multiple sclerosis (MS) patients, particular using dedicated double inversion recovery (DIR) pulse sequence.Thirty-four patients with clinically isolated syndromes or definite MS were included. All underwent resonance imaging (MRI) at 1.5 T and T, including T2-weighted turbo spin echo (TSE), fluid-attenuated (FLAIR) DIR sequences. images analysed for focal categorised according to...
Various lines of research suggest that neurotrophic processes in the hippocampus are key mechanisms major depressive disorder and relevance for response to antidepressive treatment. We performed proton magnetic resonance spectroscopy (1H-MRS) at 3 T 18 unmedicated subjects with unipolar episodes 10 age- gender-matched healthy volunteers. Thirteen patients underwent a second examination after 8 wk treatment either citalopram (n=7) or nortriptyline (n=6). Of these patients, 11 MRS datasets...
To evaluate the diagnostic value of cardiac magnetic resonance (MR) imaging at 3 T in patients suspected having acute myocarditis by using a multiparametric MR approach including T1 relaxation time as an additional tool for tissue characterization.Ethics commission approval was obtained this prospective study, and written informed consent from all subjects. Twenty four with (mean age ± standard deviation, 34.7 years 15.1; 75% men) 42 control subjects age, 38.7 10.2; 64% were included....
Cardiac magnetic resonance (CMR) can visualize inflammatory tissue changes in acute myocarditis. Several quantitative image-derived parameters have been described to enhance the diagnostic value of CMR, but no direct comparison these techniques is available.A total 34 patients with suspected myocarditis and 50 control subjects underwent CMR. CMR protocol included assessment T1 relaxation times using modified Look-Locker inversion recovery (MOLLI) shortened MOLLI (ShMOLLI) acquisition...
Purpose To prospectively compare the image quality and homogeneity of magnetic resonance (MR) images obtained by using a dual-source parallel radiofrequency (RF) excitation body MR imaging system with transmission independent RF shimming single-source standard sequences for routine clinical use in patients at 3.0 T. Materials Methods After institutional review board approval informed patient consent were obtained, 3.0-T technology was used to examine 28 compared single transmission. The...