A5022966213- Effects of Radiation Exposure
- Glioma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Brain Metastases and Treatment
- Nonmelanoma Skin Cancer Studies
- Medical Imaging Techniques and Applications
- Meningioma and schwannoma management
- Bone and Joint Diseases
- Management of metastatic bone disease
- Radiomics and Machine Learning in Medical Imaging
- Breast Cancer Treatment Studies
- Hematopoietic Stem Cell Transplantation
- Chemotherapy-related skin toxicity
- MRI in cancer diagnosis
- Cancer survivorship and care
- Advances in Oncology and Radiotherapy
- Head and Neck Cancer Studies
- Radiation Dose and Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Hematological disorders and diagnostics
- Radiation Therapy and Dosimetry
- Wnt/β-catenin signaling in development and cancer
- Cancer Treatment and Pharmacology
- Occupational and environmental lung diseases
- Toxin Mechanisms and Immunotoxins
University Hospital Bonn
2016-2025
Ferioli & Gianotti (Italy)
2024
University of Bonn
2014-2024
Klinik und Poliklinik für Strahlentherapie und Radioonkologie
2024
Universitätsklinik für Strahlentherapie
2016-2024
Government of the Republic of Korea
2020
Worldwide stroke is the second leading cause of death and third disability combined. The estimated global economic burden by over US$891 billion per year. Within three decades (1990-2019), incidence increased 70%, deaths 43%, prevalence 102%, DALYs 143%. Of 100 million people affected stroke, about 76% are ischemic (IS) patients recorded worldwide. Contextually, moves into particular focus multi-professional groups including researchers, healthcare industry, economists, policy-makers. Risk...
After surgical resection of brain metastases (BMs), intraoperative radiation therapy (IORT) provides a promising alternative to adjuvant external beam by enabling superior organ-at-risk preservation, reduction in-hospital times, and timely admission subsequent systemic treatments, which increasingly comprise novel targeted immunotherapeutic approaches. We sought assess the safety efficacy IORT in combination with immune checkpoint inhibitors (ICIs) other therapies (TTs).
Abstract The chemokine CXCL12 promotes glioblastoma (GBM) recurrence after radiotherapy (RT) by facilitating vasculogenesis. Here we report outcomes of the dose-escalation part GLORIA (NCT04121455), a phase I/II trial combining RT and CXCL12-neutralizing aptamer olaptesed pegol (NOX-A12; 200/400/600 mg per week) in patients with incompletely resected, newly-diagnosed GBM lacking MGMT methylation. primary endpoint was safety, secondary endpoints included maximum tolerable dose (MTD),...
Background Chemical shift‐encoding based water‐fat MRI is an emerging method to noninvasively assess proton density fat fraction (PDFF), a promising quantitative imaging biomarker for estimating tissue concentration. However, in vivo validation of PDFF still lacking bone marrow applications. Purpose To determine the accuracy and precision MRI‐determined vertebral among different readers across field strengths imager manufacturers. Study Type Repeatability/reproducibility. Subjects...
Radiation dermatitis (RD) represents one of the most frequent side effects in radiotherapy (RT). Despite technical progress, mild and moderate RD still affects major subsets patients identification management with a high risk severe is essential. We sought to characterize surveillance nonpharmaceutical preventive German-speaking hospitals private centers.We conducted survey on among radiation oncologists inquiring for their evaluation factors, assessment methods, RD.A total 244 health...
The aim of this review was to evaluate the existing evidence for radiotherapy brain metastases in breast cancer patients and provide recommendations use leptomeningeal carcinomatosis.
Abstract Background Radiation dermatitis (RD) is the most common side effect of breast irradiation, yet only few potent preventative and therapeutic options are available. Following encouraging results from a phase 1 2 trial on topical use non-invasive physical plasma (NIPP), very well-tolerated treatment option to promote tissue regeneration generated ambient air, we now present study protocol for planned 3 trial. Methods In this randomised double-blind placebo-controlled trial, patients...
Purpose: Radiation-induced skin injury represents one of the most common side effects in breast cancer patients receiving adjuvant whole-breast radiotherapy. Numerous systemic and topical treatments have been studied prevention management radiation-induced without providing sustainable treatment strategies. While superficial barrier-forming products such as dressings are standard care wound management, their utilization preventive approach radiotherapy has barely attracted attention.Methods:...
Radiation-induced skin injury represents the most frequent side effect in breast cancer patients undergoing whole-breast irradiation (WBI). Numerous clinical studies on systemic and topical treatments for radiation dermatitis have failed to provide sustainable treatment strategies. While protective products such as dressings are undoubtedly standard of care wound management, their utilization preventive radiotherapy has been somewhat neglected recent years. In this prospective, intra-patient...
Background: Radiation-induced dermatitis (RID) is frequent in breast cancer patients undergoing radiotherapy (RT). Spectrophotometry (SP) an objective and reliable tool for assessing RID severity. Despite intensive research efforts during the past decades, no sustainable prophylactic treatment strategies have been found. Estimation of new reevaluation established risk factors leading to severe therefore major importance. Methods: 142 early underwent whole-breast irradiation following...
Intraoperative radiotherapy (IORT) of the operative cavity for surgically treated brain metastasis (BM) has gained increasing prominence with respect to improved local tumor control. However, IORT immediately performed at time surgery might be associated increased levels perioperative adverse events (PAEs). In present study, we safety metric profiling in patients who had undergone BM and without order comparatively analyze feasibility as an adjuvant radiation approach. Between November 2020...
Radiation dermatitis (RD) is the most common acute side effect of breast irradiation. More than a century following therapeutic utilisation X-rays, potent preventative and options are still lacking. Non-invasive physical plasma (NIPP) an emerging approach towards treatment various dermatological disorders. In this study, we sought to determine safety feasibility NIPP device on RD. Thirty patients undergoing hypofractionated whole-breast irradiation were included. Parallel radiation...
Intraoperative radiation therapy (IORT) is an emerging alternative to adjuvant stereotactic external beam (EBRT) following resection of brain metastases (BM). Advantages IORT include instant prevention tumor regrowth, optimized dose-sparing adjacent healthy tissue and immediate completion BM treatment, allowing earlier admission subsequent systemic treatments. However, prospective outcome data are limited. We sought assess long-term in comparison EBRT.A total 35 consecutive patients,...