A5069496612- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Neurosurgical Procedures and Complications
- Epilepsy research and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Management of metastatic bone disease
- Intracerebral and Subarachnoid Hemorrhage Research
- Spinal Fractures and Fixation Techniques
- Vascular Malformations Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Cerebrospinal fluid and hydrocephalus
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Advanced Radiotherapy Techniques
- Ultrasound and Hyperthermia Applications
- Medical Imaging Techniques and Applications
- Intracranial Aneurysms: Treatment and Complications
- Spine and Intervertebral Disc Pathology
- Neurofibromatosis and Schwannoma Cases
- Head and Neck Surgical Oncology
- Spinal Hematomas and Complications
- Nanoplatforms for cancer theranostics
- Computational Drug Discovery Methods
- Advanced MRI Techniques and Applications
University Hospital Bonn
2013-2025
University of Bonn
2016-2024
9th City Clinical Hospital
2019
National Institute of Neurology Mongi-Ben Hamida
2014
After surgical resection of brain metastases (BMs), intraoperative radiation therapy (IORT) provides a promising alternative to adjuvant external beam by enabling superior organ-at-risk preservation, reduction in-hospital times, and timely admission subsequent systemic treatments, which increasingly comprise novel targeted immunotherapeutic approaches. We sought assess the safety efficacy IORT in combination with immune checkpoint inhibitors (ICIs) other therapies (TTs).
Objective Inflammation of brain structures, in particular the hippocampal formation, can induce neuronal degeneration and be associated with increased excitability manifesting as propensity for repetitive seizures. An increase abundance individual proinflammatory molecules including interleukin 1 beta has been observed tissue samples patients pharmacoresistant temporal lobe epilepsy (TLE) corresponding animal models. The NLRP3-inflammasome, a cytosolic protein complex, acts key regulator...
Abstract Introduction Bone mineral density (BMD) plays a crucial role in diagnosing and treating various systemic chronic diseases. Patients with multiple or singular spinal metastasis (SM) are typically advanced stages of cancer, often leading to significant alterations BMD. The present study investigated the prognostic value perioperative Hounsfield units (HU) as surrogate independent marker for estimated BMD patients SM after surgical treatment (ST). Methods HU values, serving BMD, were...
Cerebral venous sinus thrombosis (CVST) is a known complication of posterior fossa surgery near the sigmoid and transverse sinus. The incidence treatment postoperative asymptomatic CVST are controversial.To analyze incidence, risk factors, management after tumor surgery.In this retrospective, single-center study, we included all patients who underwent in semisitting position between January 2013 December 2020. All preoperative imaging using MRI with/without additional computed tomography...
Both pre- and postoperative seizures comprise common side effects that negatively impact patient quality of life in those suffering from intracranial meningioma. Therefore, seizure freedom represents an important outcome measure meningioma surgery. In the current study authors analyzed their institutional database to identify risk factors for occurrence after surgical therapy patients with preoperative symptomatic epilepsy.
Abstract Objective Transsylvian selective amygdalo‐hippocampectomy (tsSAHE) represents a generally recognized surgical procedure for drug‐resistant mesial temporal lobe epilepsy (mTLE). Although postoperative seizure freedom can be achieved in about 70% of tsSAHE, there is considerable amount patients with persisting seizures. This might partly explained by differing extents resection various tsSAHE target volumes. In this study we analyzed the resected proportions hippocampus, amygdala as...
The postoperative seizure freedom represents an important secondary outcome measure in glioblastoma surgery. Recently, supra-total resection terms of anterior temporal lobectomy (ATL) has gained growing attention with regard to superior long-term disease control for temporal-located compared conventional gross-total resections (GTR). However, the impact ATL on these patients is unknown. We therefore analyzed and GTR as differing extents preoperative symptomatic seizures.Between 2012 2018, 33...
Intraoperative radiotherapy (IORT) of the operative cavity for surgically treated brain metastasis (BM) has gained increasing prominence with respect to improved local tumor control. However, IORT immediately performed at time surgery might be associated increased levels perioperative adverse events (PAEs). In present study, we safety metric profiling in patients who had undergone BM and without order comparatively analyze feasibility as an adjuvant radiation approach. Between November 2020...
Spinal dorsal instrumentation (SDI) is an established treatment for degenerative spinal diseases. Adequate and immediate postoperative pain control important patient recovery may be compromised by uncertainty about its efficacy concern early surgical complications or adverse events. The aim of the current study was to compare use epidural analgesia (EA) with systemic (SA) as regards reduction after SDI. Pain management in patients undergoing SDI posterior approach between January 2019 July...
Abstract Introduction Supra-total resection in terms of anterior temporal lobectomy (ATL) has gained growing attention with regard to superior long-term disease control for temporal-located glioblastoma. However, aggressive onco-surgical approaches—geared beyond conventional gross total resections (GTR)—may be associated peri- and postoperative unfavorable events which significantly worsen initial favorable outcome. In the current study we analyzed our institutional database patient safety...
Intra-tumoral hemorrhage is considered an imaging characteristic of advanced cancer disease. However, data on the influence intra-tumoral in patients with brain metastases (BM) remains scarce. We aimed at investigating BM who underwent neurosurgical resection metastatic lesion for a potential impact preoperative hemorrhagic transformation overall survival (OS).Between 2013 and 2018, 357 were surgically treated authors' neuro-oncological center. Preoperative magnetic resonance (MRI)...
Intraoperative radiation therapy (IORT) is an emerging alternative to adjuvant stereotactic external beam (EBRT) following resection of brain metastases (BM). Advantages IORT include instant prevention tumor regrowth, optimized dose-sparing adjacent healthy tissue and immediate completion BM treatment, allowing earlier admission subsequent systemic treatments. However, prospective outcome data are limited. We sought assess long-term in comparison EBRT.A total 35 consecutive patients,...
OBJECTIVE Cavernoma-related epilepsy (CRE) is a frequent symptom in patients with cerebral cavernous malformations (CCMs). Reports on surgical management and seizure outcome of epileptogenic CCM often focus intracranial cavernoma general. Therefore, data CCMs within the temporal lobe are scarce. The authors therefore analyzed their institutional data. METHODS From 2003 to 2018, 52 suffering from located underwent surgery for CRE at University Hospital Bonn. Information patient...
Abstract Surgical resection is a common treatment modality for brain metastasis (BM). Location of the BM might significantly impact patient survival and therefore be considered in clinical decision making counseling. In present study, authors analyzed infra- supratentorial location potential prognostic difference. Between 2013 2019, 245 patients with solitary received at authors’ neuro-oncological center. order to produce covariate balance commonly-known variables (tumor entity, age,...
Abstract Purpose Intraoperative radiotherapy (IORT) has become a viable treatment option for resectable brain metastases (BMs). As data on local control and radiation necrosis rates are maturing, we focus meaningful secondary endpoints such as time to next (TTNT), duration of postoperative corticosteroid treatment, in-hospital time. Methods Patients prospectively recruited within an IORT study registry between November 2020 June 2023 were compared with consecutive patients receiving adjuvant...
Object: Inflammatory response is an important determinant of subsequent brain injury after deep-seated intracerebral hemorrhage (ICH). The ratio red blood cell (RBC) distribution width to platelet count (RPR) has been established as a new index reflect the severity inflammation. To best our knowledge, no association between RPR and prognosis spontaneous ICH yet reported. Methods: In all patients with treated at Neurovascular Center from 2014 2020, initial laboratory values were obtained...
Recently, we showed that resection of at least 27% the temporal part piriform cortex (PiC) strongly correlated with seizure freedom 1 year following selective amygdalo-hippocampectomy (tsSAHE) in patients mesial lobe epilepsy (mTLE). However, impact PiC on long-term outcome tsSAHE is currently unknown. The aim this study was to evaluate mTLE treated tsSAHE.
The best time for cranioplasty (CP) after decompressive craniectomy (DC) is controversial, and there are no authoritative guidelines yet. Both complications as well outcome may depend on the timing of CP. aim this single-center study was to evaluate impact late CP procedural safety patient outcome.
Abstract Purpose Patients with spinal metastases (SM) from solid neoplasms typically exhibit progression to an advanced cancer stage. Such can either develop concurrently existing diagnosis (termed metachronous SM) or emerge as the initial indication of undiagnosed malignancy (referred synchronous SM). The present study investigates prognostic implications compared SM following surgical resection. Methods From 2015 2020, a total 211 individuals underwent intervention for at our...