A5065222436- Brain Metastases and Treatment
- Cancer Immunotherapy and Biomarkers
- Acute Lymphoblastic Leukemia research
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Chronic Myeloid Leukemia Treatments
- Management of metastatic bone disease
- CAR-T cell therapy research
- Glioma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Genomics and Chromatin Dynamics
- Chronic Lymphocytic Leukemia Research
- RNA and protein synthesis mechanisms
- Lung Cancer Research Studies
- Acute Myeloid Leukemia Research
- Neutropenia and Cancer Infections
- PI3K/AKT/mTOR signaling in cancer
- Fungal Infections and Studies
- Inflammatory Biomarkers in Disease Prognosis
- Protein Kinase Regulation and GTPase Signaling
- Antibiotic Use and Resistance
- Meningioma and schwannoma management
- Advancements in Semiconductor Devices and Circuit Design
- Spaceflight effects on biology
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)
2021-2025
University Hospital Bonn
2016-2023
Heinrich Heine University Düsseldorf
2023
Düsseldorf University Hospital
2023
University of Bonn
2013-2022
Jena University Hospital
2019
Despite recent advances in adapting the intensity of treatment for older patients with ALL, current protocols are associated high rates early deaths, treatment-related toxicity, and dismal prognosis. We evaluated inotuzumab ozogamicin dexamethasone (Dex) as induction therapy ALL within German Multicenter Study Group Adult (GMALL).
Background Immune checkpoint inhibitors (ICIs) for cancer treatment are associated with a spectrum of immune-related adverse events, including ICI-induced myocarditis; however, the extent subclinical acute cardiac effects related to ICI is unclear. Purpose To explore injury and inflammation therapy that can be detected use MRI. Materials Methods In this prospective study from November 2019 April 2021, oncologic participants, without known underlying structural heart disease or symptoms,...
Management of patients with metastatic squamous cell skin cancer, refractory to initial therapy standard chemotherapy and radiation protocols, remains difficult poor overall prognosis limited therapeutic options. Recently, promising response rates nivolumab, a programmed death receptor-1-blocking antibody, in cancer the head neck have been demonstrated. Considering similar histological patterns neck, we assumed that nivolumab could also be effective our skin. So far, there no clinical data...
Abstract In recent years the tumor suppressor p53 has been increasingly recognized as a potent regulator of cell metabolism and for its ability to inhibit critical pro-survival kinases AKT mTOR. The mechanisms through which controls mTOR, however, are largely unclear. Here, we demonstrate that activates metabolic DDIT4 indirectly regulatory factor X 7 (RFX7). We provide evidence is required mTOR complex 2 (mTORC2)-dependent activation. Most strikingly, also find RFX7 p53-mediated inhibition...
Abstract Despite its prominence, the mechanisms through which tumor suppressor p53 regulates most genes remain unclear. Recently, regulatory factor X 7 (RFX7) emerged as a of lymphoid neoplasms, but regulation and target mediating suppression unknown. Here, we identify novel p53-RFX7 signaling axis. Integrative analysis RFX7 DNA binding landscape RFX7-regulated transcriptome in three distinct cell systems reveals that directly controls multiple established suppressors, including PDCD4,...
Abstract Convergent transcription, that is, the collision of sense and antisense is ubiquitous in mammalian genomes believed to diminish RNA expression. Recently, transcription downstream promoters was found be surprisingly prevalent. However, functional characteristics affected are poorly investigated. Here we show convergent marks an unexpected positively co-regulated promoter constellation. By assessing transcriptional dynamic systems, identified constituent connected through a distinct...
Surgical resection is a key treatment modality for brain metastasis (BM). However, peri- and postoperative adverse events (PAEs) might be associated with detrimental impact on outcome. We retrospectively analyzed our institutional database regard to patient safety indicators (PSIs), hospital-acquired conditions (HACs) specific cranial surgery-related complications (CSCs) as high-quality metric profiles PAEs in patients who had undergone surgery BM department between 2013 2018. The...
Intra-tumoral hemorrhage is considered an imaging characteristic of advanced cancer disease. However, data on the influence intra-tumoral in patients with brain metastases (BM) remains scarce. We aimed at investigating BM who underwent neurosurgical resection metastatic lesion for a potential impact preoperative hemorrhagic transformation overall survival (OS).Between 2013 and 2018, 357 were surgically treated authors' neuro-oncological center. Preoperative magnetic resonance (MRI)...
Object In the light of an aging population and ongoing advances in cancer control, optimal management geriatric patients with brain metastases (BM) poses increasing challenge, especially due to scarce data available. We therefore analyzed our institutional regard factors influencing overall survival (OS) BM. Methods Between 2013 2018, aged ≥ 65 years surgically treated BM were included this retrospective analysis. search preoperatively identifiable risk for poor OS, addition underlying...
Recurrently mutated in lymphoid neoplasms, the transcription factor RFX7 is emerging as a tumor suppressor. Previous reports suggested that may also have role neurological and metabolic disorders. We recently reported responds to p53 signaling cellular stress. Furthermore, we found target genes be dysregulated numerous cancer types beyond hematological system. However, our understanding of RFX7's gene network its health disease remains limited. Here, generated knock-out cells employed...
Hospitals with their high antimicrobial selection pressure represent the presumably most important reservoir of multidrug-resistant human pathogens. Antibiotics administered in course treatment are excreted and discharged into wastewater system. Not only patients, but also sewers, substances exert on existing bacteria promote emergence dissemination clones. In previous studies, two main clusters were identified all sections hospital network that was investigated, one K. pneumoniae ST147...
Treatment options for patients with platinum-refractory, recurrent, metastatic head and neck squamous cell carcinoma (HNSCC) are limited, prognosis is poor. Nivolumab (Opdivo) has been approved by the US Food Drug Administration (FDA) treatment of recurrent or HNSCC who have disease progression on after platinum-based therapy. Recently, in malignant melanoma a significant improvement outcome response was achieved combination ipilimumab (CTLA4 antibody) programmed death (PD)-1 inhibitor...
Objective Surgical resection represents a common treatment modality in patients with brain metastasis (BM). Postoperative prolonged mechanical ventilation (PMV) might have an enormous impact on the overall survival (OS) of these suffering from advanced cancer disease. We therefore analyzed our institutional database regard to potential PMV OS who had undergone surgery for metastases. Methods 360 surgically treated metastases were included. The definition consisted postoperative lasting more...
Oxidative modification of cysteine residues has been shown to regulate the activity several protein-tyrosine kinases. We explored possibility that Fms-like tyrosine kinase 3 (FLT3), a hematopoietic receptor-tyrosine kinase, is subject this type regulation. An underlying rationale was FLT3 gene frequently mutated in Acute Myeloid Leukemia patients, and resulting oncogenic variants with 'internal tandem duplications (FLT3ITD)' drive production reactive oxygen leukemic cells. moderately...
Background: Metastatic melanoma disease is accompanied by highly systemic inflammatory responses. The prognostic value of preoperative laboratory inflammation markers in brain metastatic patients has not been adequately investigated so far. Methods: Preoperative blood parameters were correlated to overall survival (OS) rates that underwent surgery for metastasis (BM) between 2013 and 2019 at the authors’ institution. Receiver operating characteristic (ROC) analyses used cutoff determination...
Abstract The transcription factor regulatory X 7 (RFX7) has been identified as a tumor suppressor that is recurrently mutated in lymphoid cancers and appears to be dysregulated many other cancers. RFX7 activated by the well-known p53 regulates several known genes. However, what factors regulate its target genes remains unclear. Here, reporter gene assays were used identify PDCD4 through direct interaction with X-box promoter motif. We utilized mass spectrometry bind DNA together RFX7. In...
Management of patients with metastatic squamous cell cancer the head and neck, refractory to initial therapy standard chemo- radiation protocols, remains difficult poor overall prognosis limited therapeutic options. Nivolumab (a programmed death receptor-1 ,PD-1 blocking antibody) has been approved in Germany since June 2017 for treatment carcinoma neck adults. combination Ipilimumab (an anti-CTLA 4 is licenced EU advanced (unresectable or metastatic) melanoma In April 2018, Food Drug...
There are conflicting results concerning the outcome of patients after an allogeneic hematopoietic stem cell transplantation (allo-HSCT) who required treatment in intensive care unit (ICU). The aim this study was to evaluate and prognostic parameters terms patient survival allo-HSCT admission ICU within first 30 days transplantation.Patients allo-HSCT, were ≥18 years admitted initiation conditioning therapy at University Hospital Bonn between January 2017 April 2021, analysed...
Abstract Circadian clock disruption and lack of sleep impair health cells organs, but mechanisms remain elusive. Here, we used multi-omics, molecular functional assays in three model systems ( C. elegans , human retinal mouse brain) to identify the DREAM complex as a ubiquitous repressor acting downstream impairment. We show that dysfunction aberrantly activates leading simultaneous de-regulation multiple cellular processes. The affected activities including translation, stress responses...