A5020945421- Genetics, Aging, and Longevity in Model Organisms
- Mitochondrial Function and Pathology
- DNA Repair Mechanisms
- Immune Response and Inflammation
- CRISPR and Genetic Engineering
- interferon and immune responses
- Circadian rhythm and melatonin
- Cell death mechanisms and regulation
- Diet and metabolism studies
- Pluripotent Stem Cells Research
- FOXO transcription factor regulation
- NF-κB Signaling Pathways
- Dietary Effects on Health
- Inflammasome and immune disorders
- Influenza Virus Research Studies
- Adipose Tissue and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Library Science and Information
- Spaceflight effects on biology
- Ubiquitin and proteasome pathways
- Genomics, phytochemicals, and oxidative stress
- Aluminum toxicity and tolerance in plants and animals
- Discourse Analysis and Cultural Communication
- Genetic and Kidney Cyst Diseases
- Cancer, Lipids, and Metabolism
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)
2016-2025
Friedrich Schiller University Jena
2024
Russian Academy of Sciences
2002-2021
Leibniz Association
2020
University of Cologne
2008-2016
Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
2008-2016
European Molecular Biology Laboratory
2008
Institute of Gene Biology
2002-2004
Ribosome biogenesis is initiated by RNA polymerase I (Pol I)-mediated synthesis of pre-ribosomal (pre-rRNA). Pol activity was previously linked to longevity, but the underlying mechanisms were not studied beyond effects on nucleolar structure and protein translation. Here we use multi-omics functional tests show that curtailment remodels lipidome preserves mitochondrial function promote longevity in Caenorhabditis elegans. Reduced pre-rRNA improves energy homeostasis metabolic plasticity...
Mammals display a wide range of variation in their lifespan. Investigating the molecular networks that distinguish long- from short-lived species has proven useful to identify determinants longevity. Here, we compared livers young and old long-lived naked mole-rats (NMRs) phylogenetically closely related, shorter-lived, guinea pigs using an integrated omics approach. We found NMR unique expression pattern mitochondrial proteins results distinct metabolic features mitochondria. For instance,...
Abstract The tumour suppressor CYLD is a deubiquitinase previously shown to inhibit NF-κB, MAP kinase and Wnt signalling. However, the suppressing mechanisms of remain poorly understood. Here we show that loss catalytic activity causes impaired DNA damage-induced p53 stabilization activation in epithelial cells sensitizes mice chemical carcinogen-induced intestinal skin tumorigenesis. Mechanistically, interacts with deubiquitinates facilitating its response genotoxic stress. Ubiquitin...
Abstract Cell death programs such as apoptosis and ferroptosis are associated with aberrant redox homeostasis linked to lipid metabolism membrane function. Evidence for cross-talk between these is emerging. Here, we show that cytotoxic stress channels polyunsaturated fatty acids via lysophospholipid acyltransferase 12 into phospholipids become susceptible peroxidation under additional stress. This reprogramming altered acyl-CoA synthetase isoenzyme expression caused by a decrease in growth...
Aging is a complex process that can be characterized by functional and cognitive decline in an individual. assessed based on the capacity of vital organs their intricate interactions with one another. Thus, nature aging described focusing specific organ individual itself. However, to fully understand complexity aging, must investigate not only single tissue or biological but also its interplay interdependencies other processes. Here, using RNA-seq, we monitored changes transcriptome during...
Abstract DNA damage by ultraviolet (UV) light poses a risk for mutagenesis and potential hindrance cell cycle progression. Cells cope with UV-induced through two general strategies to repair the damaged nucleotides promote progression in presence of UV-damaged DNA. Defining genetic pathways understanding how they function together enable effective tolerance UV remains an important area research. The structural maintenance chromosomes (SMC) proteins form distinct complexes that maintain...
Antibiotics are commonly used in the Intensive Care Unit (ICU); however, several studies showed that impact of antibiotics to prevent infection, multi-organ failure, and death ICU is less clear than their benefit on course infection absence organ dysfunction. We characterized here compositional metabolic changes gut microbiome induced by critical illness a cohort 75 individuals conjunction with 2,180 samples representing 16 different diseases. revealed an "infection-vulnerable" environment...
Hormesis is a phenomenon whereby low-level stress can improve cellular, organ, or organismal fitness in response to subsequent similar other insult. Whereas hormesis thought contribute the benefits arising from symbiotic host-microbe interactions, putative of host-pathogen interactions have yet be explored. Hormetic responses nonetheless been reported experimental models infection, common feature which regulation host mitochondrial function. We propose that these mitohormetic could harnessed...
DNA damage causally contributes to cancer development and tissue degeneration with aging.Citation1 Cellular responses (DDR) mediate cell cycle arrest allow time for repair, or induce cellular senescence apoptosis eliminate damaged cells.Citation2 In contrast cell-autonomous responses, it remains less clear how organisms respond genome instability in certain types distinct tissues interact when responding tissue-specific damage. C. elegans comprises an intriguing system study the interaction...