A5002187458- Gut microbiota and health
- Bacteriophages and microbial interactions
- Diet and metabolism studies
- Respiratory viral infections research
- Genetics, Bioinformatics, and Biomedical Research
- Machine Learning in Bioinformatics
- Metabolomics and Mass Spectrometry Studies
- Dietary Effects on Health
- Liver Disease Diagnosis and Treatment
- Clostridium difficile and Clostridium perfringens research
- Ginseng Biological Effects and Applications
- Antibiotic Resistance in Bacteria
- Nutrition, Genetics, and Disease
- Epigenetics and DNA Methylation
- Probiotics and Fermented Foods
- Diabetes and associated disorders
- Fibroblast Growth Factor Research
- Pancreatic and Hepatic Oncology Research
- Nutrition and Health in Aging
- Pharmacogenetics and Drug Metabolism
- Clinical Nutrition and Gastroenterology
- Influenza Virus Research Studies
- Biochemical Analysis and Sensing Techniques
- Immune cells in cancer
- Microbial Metabolic Engineering and Bioproduction
Shanghai Jiao Tong University
2021-2025
Shanghai Sixth People's Hospital
2021-2025
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)
2019-2024
Friedrich Schiller University Jena
2023-2024
University of Hong Kong
2015-2021
Significance Hepatocellular carcinoma is the second most deadly cancer type globally, requiring development of alternative or complementary therapeutic and prophylactic methods. Here, when feeding a mouse model with novel probiotic mixture 1 wk before tumor inoculation, we observed reduction weight size by 40% compared control. Our results revealed that probiotics’ beneficial effect closely related abundance certain bacteria produce antiinflammatory metabolites, which subsequently regulate...
Abstract Although obesity occurs in most of the patients with type 2 diabetes (T2D), a fraction T2D are underweight or have normal weight. Several studies linked gut microbiome to and T2D, but role microbiota lean individuals having unique clinical characteristics remains unclear. A metagenomic targeted metabolomic analysis is conducted 182 abdominally obese without newly diagnosed T2D. The abundance Akkermansia muciniphila ( A. ) significantly decreases than not comparison Its correlates...
A growing body of evidence suggests interplay between the gut microbiota and pathogenesis nonalcoholic fatty liver disease (NAFLD). However, role microbiome in early detection NAFLD is unclear. Prospective studies are necessary for identifying reliable, markers NAFLD. We evaluated 2487 individuals a community-based cohort who were followed up 4.6 years after initial clinical examination biospecimen sampling. Metagenomic metabolomic characterizations using stool serum samples taken at...
Abstract Emerging evidence suggests that modulation of gut microbiota by dietary fibre may offer solutions for metabolic disorders. In a randomized placebo-controlled crossover design trial (ChiCTR-TTRCC-13003333) in 37 participants with overweight or obesity, we test whether resistant starch (RS) as supplement influences obesity-related outcomes. Here, show RS supplementation 8 weeks can help to achieve weight loss (mean −2.8 kg) and improve insulin resistance individuals excess body...
Abstract The gut microbiota has the potential to influence efficacy of cancer therapy. Here, we investigated contribution intestinal microbiome on treatment outcomes in a heterogeneous cohort that included multiple types identify microbes with global impact immune response. Human metagenomic analysis revealed responder patients had significantly higher microbial diversity and different compositions compared non-responders. A machine-learning model was developed validated an independent...
Abstract Resistant starch (RS) has been reported to reduce body fat in obese mice. However, this effect not demonstrated humans. In study, we tested the effects of RS 19 volunteers with normal weights. A randomized, double-blinded and crossover design clinical trial was conducted. The study subjects were given either 40 g high amylose RS2 or energy-matched control three identical diets per day throughout study. evaluated by monitoring fat, glucose metabolism, gut hormones, microbiota,...
Abstract Cachexia is associated with decreased survival in cancer patients and has a prevalence of up to 80%. The etiology cachexia poorly understood, limited treatment options exist. Here, we investigated the role human gut microbiome by integrating shotgun metagenomics plasma metabolomics 31 lung patients. group showed significant differences microbial composition, functional pathways metagenome, related metabolites compared non-cachectic Branched-chain amino acids (BCAAs),...
Viruses are important components of microbial communities modulating community structure and function; however, only a couple tools currently available for phage identification analysis from metagenomic sequencing data. Here we employed the random forest algorithm to develop VirMiner, web-based contig prediction tool especially sensitive high-abundances contigs, trained validated by paired phagenomic data human gut flora.VirMiner achieved 41.06% ± 17.51% sensitivity 81.91% 4.04% specificity...
The pathogenesis of non-alcoholic fatty liver disease (NAFLD) with a global prevalence 30% is multifactorial and the involvement gut bacteria has been recently proposed. However, finding robust bacterial signatures NAFLD great challenge, mainly due to its co-occurrence other metabolic diseases. Here, we collected public metagenomic data integrated taxonomy profiles in silico generated community outputs, detailed clinical data, 1206 Chinese subjects w/wo diseases, including (obese lean),...
Visceral fat is an independent risk factor for metabolic and cardiovascular disease. The study aimed to investigate the associations between gut microbiome visceral fat.We recruited 32 obese adults 30 healthy controls at baseline. Among subjects, 14 subjects underwent laparoscopic sleeve gastrectomy (LSG) were followed 6 months after surgery. Abdominal area (VFA) subcutaneous (SFA) measured by magnetic resonance imaging. Waist, hipline, waist-to-hip ratio (WHR) body mass index (BMI) included...
Aspergillus fumigatus, an opportunistic human pathogen, frequently infects the lungs of people with cystic fibrosis and is one most common causes infectious-disease death in immunocompromised patients. Here, we construct 252 strain-specific, genome-scale metabolic models this important fungal pathogen to study better understand component its pathogenic versatility. The show that 23.1% A. fumigatus reactions are not conserved across strains mainly associated amino acid, nucleotide, nitrogen...
Oral antibiotics are commonly prescribed to non-hospitalized adults. However, antibiotic-induced changes in the human gut microbiome often investigated cohorts with preexisting health conditions and/or concomitant medication, leaving effects of not completely understood. We used a combination omic approaches comprehensively assess on microbiota and particularly resistome small cohort healthy observed that 3 19 species per individual proliferated during antibiotic treatment Gram-negative...
The gut microbiota is a newly identified contributor to the development of non-alcoholic fatty liver disease (NAFLD). Previous studies Bifidobacterium adolescentis ( B. ), species that common in human intestinal tract, have demonstrated it can alleviate steatosis and steatohepatitis. Fibroblast growth factor 21 (FGF21) has long been considered as biomarker NAFLD, recent shown protective effect FGF21 analogs on NAFLD. We wondered whether treatment would NAFLD via interaction with FGF21. To...
As diet is considered the major regulator of gut ecosystem, overall objective this work was to demonstrate that a detailed knowledge phytochemical composition food could add our understanding observed changes in functionality and activity microbiota. We used metatranscriptomic data from human dietary intervention study develop network consists >400 compounds present administered plant-based linked 609 microbial targets gut. Approximately 20% targeted bacterial proteins showed significant...
Abstract Candida albicans is a leading cause of life-threatening hospital-acquired infections and can lead to Candidemia with sepsis-like symptoms high mortality rates. We reconstructed genome-scale C. metabolic model investigate bacterial-fungal interactions in the gut as determinants fungal abundance. optimized predictive capacity our using wild type mutant growth data used it for silico interaction predictions. Our analysis more than 900 paired fungal–bacterial models predicted key...
Abstract Currently, there is evidence that alteration in the gut ecosystem contributes to development of liver diseases, however, complex mechanisms involved are still unclear. We induced cholestasis mice by bile duct ligation (BDL), mirroring phenotype a obstruction, understand how microbiota alterations caused an impaired flow acid contribute pathogenesis and progression disease. performed longitudinal stool, heart, sampling using receiving BDL controls sham operation (ShamOP). Shotgun...
Recent research has demonstrated that consumption of food -especially fruits and vegetables- can alter the effects drugs by interfering either with their pharmacokinetic or pharmacodynamic processes. Despite recognition such drug-food associations as an important element for successful therapeutic interventions, a systematic approach identifying, predicting preventing potential interactions between marketed novel is not yet available. The overall objective this work was to sketch...
Background The importance of gut microbes in mediating the benefits lifestyle intervention is increasingly recognized. However, compared to bacterial microbiome, role intestinal fungi exercise remains elusive. With our established randomized controlled trial Chinese males with prediabetes (n = 39, ClinicalTrials.gov:NCT03240978), we investigated dynamics human mycobiome and further interrogated their associations exercise-elicited outcomes using multi-omics approaches.
Antibiotics are commonly used in the Intensive Care Unit (ICU); however, several studies showed that impact of antibiotics to prevent infection, multi-organ failure, and death ICU is less clear than their benefit on course infection absence organ dysfunction. We characterized here compositional metabolic changes gut microbiome induced by critical illness a cohort 75 individuals conjunction with 2,180 samples representing 16 different diseases. revealed an "infection-vulnerable" environment...
http://sbb.hku.hk/services/NutriChem-2.0/.
Impaired exercise tolerance and lung function is a marker for increased mortality in cancer patients undergoing resection surgery. Recent data suggest that the gut-lung axis regulates systemic metabolic immune functions, microbiota might alter tolerance. Here, we aimed to evaluate associations between gut outcomes who underwent We analysed stool samples, from 15 early-stage patients, collected before after surgical using shotgun metagenomic Internal Transcribed Spacer (ITS) sequencing....
Background: A range of computational methods that rely on the analysis genome-wide expression datasets have been developed and successfully used for drug repositioning. The success these is based hypothesis introducing a factor (in this case, molecule) could reverse disease gene signature will lead to therapeutic effect. However, it has also shown globally reversing not prerequisite activity. On other hand, basic idea significant anti-correlation in profiles great value establishing...