A5100395175- Legume Nitrogen Fixing Symbiosis
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Chromosomal and Genetic Variations
- Genomics and Phylogenetic Studies
- Plant nutrient uptake and metabolism
- Plant-Microbe Interactions and Immunity
- Nematode management and characterization studies
- Plant Virus Research Studies
- Banana Cultivation and Research
- Bacteriophages and microbial interactions
- Plant Molecular Biology Research
- Plant responses to water stress
- Plant Stress Responses and Tolerance
- HIV/AIDS Research and Interventions
- Gut microbiota and health
- Soil Carbon and Nitrogen Dynamics
- Mycotoxins in Agriculture and Food
- RNA and protein synthesis mechanisms
- Estrogen and related hormone effects
- Rice Cultivation and Yield Improvement
- Agronomic Practices and Intercropping Systems
- Ruminant Nutrition and Digestive Physiology
- Diet and metabolism studies
- Plant Pathogens and Resistance
North University of China
2025
Dezhou University
2025
General Hospital of Shenyang Military Region
2025
Chinese People's Liberation Army
2025
South China Agricultural University
2024
Northeast Agricultural University
2023-2024
Academy of Military Medical Sciences
2023-2024
Institute of Microbiology
2014-2024
China Agricultural University
2017-2024
Guizhou University
2024
Abstract Human gut microbiome is a promising target for managing type 2 diabetes (T2D). Measures altering microbiota like oral intake of probiotics or berberine (BBR), bacteriostatic agent, merit metabolic homoeostasis. We hence conducted randomized, double-blind, placebo-controlled trial with newly diagnosed T2D patients from 20 centres in China. Four-hundred-nine eligible participants were enroled, randomly assigned (1:1:1:1) and completed 12-week treatment either BBR-alone,...
Abstract Copy number variations (CNVs) are implicated across many neurodevelopmental disorders (NDDs) and contribute to their shared genetic etiology. Multiple studies have attempted identify etiology among NDDs, but this is the first genome-wide CNV analysis autism spectrum disorder (ASD), attention deficit hyperactivity (ADHD), schizophrenia (SCZ), obsessive-compulsive (OCD) at once. Using microarray (Affymetrix CytoScan HD), we genotyped 2,691 subjects diagnosed with an NDD (204 SCZ,...
Abstract Genetic and environmental factors collectively determine plant growth yield. In the past 20 years, genome-wide association studies (GWAS) have been conducted on crops to decipher genetic loci that contribute yield, however, genotype appears be insufficient explain trait variations. Here, we unravel associations between genotypic, phenotypic, rhizoplane microbiota variables of 827 foxtail millet cultivars by an integrated GWAS, microbiome-wide (MWAS) microbiome (mGWAS) method. We...
Importance Olamkicept, a soluble gp130-Fc-fusion-protein, selectively inhibits interleukin 6 (IL-6) trans-signaling by binding the IL-6 receptor/IL-6 complex. It has anti-inflammatory activities in inflammatory murine models without immune suppression. Objective To assess effect of olamkicept as induction therapy patients with active ulcerative colitis. Design, Setting, and Participants Randomized, double-blind, placebo-controlled phase 2 trial 91 adults colitis (full Mayo score ≥5, rectal...
Abstract Root-associated microbiomes contribute to plant growth and health, are dynamically affected by development changes in the soil environment. However, how different fertilizer regimes affect quantitative microbial assembly effect remains obscure. Here, we explore temporal dynamics of root-associated bacteria soybean using microbiome profiling (QMP) examine its response unbalanced treatments (i.e., lacking either N, P or K) role sustaining after four decades fertilization. We show that...
The mechanisms leading to hepatic venoocclusive disease (HVOD) remain largely unknown. Azathioprine and monocrotaline were studied as part of a series studies looking at variety toxins that induce HVOD find common features might be pathogenic significance. In previous study, dacarbazine showed selective in vitro toxicity sinusoidal endothelial cells (SEC) compared with hepatocytes key role for SEC glutathione (GSH) was demonstrated. Murine isolated culture. found selectively more toxic than...
The interaction of FtsZ with itself, GTP, and FtsA was examined by analyzing the sensitivity to proteolysis using yeast two-hybrid system. N-terminal conserved domain consisting 320 amino acids bound a central region FtsZ, encompassing slightly more than half protein, cross-linked GTP. Site-directed mutagenesis revealed that none six highly aspartic acid asparagine residues were required for GTP binding. These results indicate specificity determinants binding are different those GTPase...
SSR-based QTL mapping provides useful information for map-based cloning of major QTLs and can be used to improve the agronomic quality traits in cultivated peanut by marker-assisted selection. Cultivated (Arachis hypogaea L.) is an allotetraploid species (AABB, 2n = 4× 40), valued its edible oil digestible protein. Linkage has been successfully conducted most crops, it applied detect quantitative trait loci (QTLs) biotic abiotic peanut. However, genetic basis quality-related remains unclear....
Non-fasting lipidemia (nFL), mainly contributed by postprandial (PL), has recently been recognized as an important cardiovascular disease (CVD) risk fasting (FL). PL serves a common feature of dyslipidemia in Type 2 Diabetes (T2D), albeit effective therapies targeting on were limited. In this study, we aimed to evaluate whether the therapy combining probiotics (Prob) and berberine (BBR), proven antidiabetic hypolipidemic regimen via altering gut microbiome, could effectively reduce T2D...
This trial was designed to investigate the effects of industrial hemp ethanol extraction byproduct (IHEEB) and Chinese wildrye hay (CWH) replacement alfalfa (AH) on digestibility, lactation performance, plasma metabolites, ruminal fermentation, bacterial communities in Holstein dairy cows. Nine healthy multiparous cows (parity = 3) with similar body weights (584 ± 12.3 kg), days milk (108 11.4), yields (30 1.93 kg; all mean standard deviation) were used a replicated 3 × Latin square design...
Seed endophytic microbiomes are shaped by host and environmental factors play a crucial role in their growth health. Studies have demonstrated that genotype, including hybridization, affects seed microbiomes. Heterosis features also observed root-associated It remains unclear, however, whether heterosis exists hybrid microbiota provide noticeable advantages to plant growth, especially germination. Here, we investigated the structure of bacterial fungal communities from three rice varieties...
Rubisco activase (RCA) catalyzes the activation of in vivo and plays a crucial role photosynthesis. However, until now, little was known about molecular genetics RCA soybean (Glycine max), one most important legume crops. Here, we cloned characterized two genes encoding longer alpha -isoform shorter beta (GmRCA GmRCA beta, respectively). The corresponding cDNAs are divergent both translated 3 ' untranslated regions. Analysis genomic DNA sequences suggested that mRNAs transcripts different...
Summary Sea buckthorn ( Hippophae rhamnoides ), a horticulturally multipurpose species in the family Elaeagnaceae, can build associations with Frankia actinomycetes to enable symbiotic nitrogen‐fixing. Currently, no high‐quality reference genome is available for an actinorhizal plant, which greatly hinders study of nodulation. Here, by combining short‐read, long‐read and Hi‐C sequencing technologies, we generated chromosome‐level H. (scaffold N50: 65 Mb, size: 730 Mb) predicted 30 812...
Summary Microbiota colonize every accessible plant tissue and play fundamental roles in growth health. Soybean stay‐green syndrome (SGS), a condition that causes delayed leaf senescence (stay‐green), flat pods abnormal seeds of soybean, has become the most serious disease soybean China. However, direct cause SGS is highly debated, little known about how affect microbiome dynamics, particularly seed microbiome. We studied bacterial, fungal, viral communities associated with different tissues...